25(OH)D Serum Level in Non-Diabetic and Type II Diabetic Patients: A Cross-Sectional Study (original) (raw)
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Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2022
The link between the risk of type 2 diabetes mellitus (T2DM) and vitamin D deficiency has perplexed the medical society due to the controversy in the data available. Saudi Arabia (SA) is a sunny region; however, ample amount of data reported the increased prevalence of vitamin D deficiency along with T2DM. Thus, this study aimed to compare vitamin D deficiency between healthy and T2DM patients in SA, alongside with the risk factors associated with that. Methods: A cross-sectional study was conducted in the Medical Unit, Taibah University in Al-Madinah Al-Munawarah, SA, from November 2017 to May 2018. The involved participants were non-diabetics and T2DM men. Measuring vitamin D for T2DM and non-diabetics group was done by trained technicians. Data analysis was done via SPSS. Results: Sixty-four participants (T2DM group = 32; non-diabetics group = 32) were recruited, and the mean age of T2DM patients was 48.6 ± 10.4, while that of the non-diabetics was 42.4 ± 6.5. The mean of vitamin D level was found higher in the non-diabetic participants than in diabetic patients. There was statistically significant association between vitamin D deficiency and T2DM (P = 0.001). Besides, duration of diabetes was the only factor, found to be positively correlated with vitamin D deficiency in T2DM patients. Conclusion: Early screening for vitamin D serum-level is recommended for T2DM patients in Saudi Arabia. Therefore, early correction of vitamin D levels should be considered, and medical and scientific societies, along with other sectors such as the media, should highlight and increase the awareness of the importance of vitamin D and the seriousness of its deficiency.
BMC public health, 2016
Vitamin D homeostasis may play a critical role in glucose metabolism. Little is known on vitamin D deficiency and its association with diabetes in countries of the Arabia Gulf where the population is experiencing a rapid increase in the incidence of diabetes. In a cross-sectional study of 960 adults enrolled in the first National Nutrition Survey of the State of Kuwait (NNSSK), we examined vitamin D status in association with the prevalence of diabetes and prediabetes. Vitamin D status was measured by serum levels of 25-hydroxyvitami D (25(OH)D). Prevalences of diabetes and prediabetes were determined based on fasting glucose and HbA1C levels. The median level of serum 25(OH)D in Kuwaiti adults was 13.8 ng/ml. Approximately 56 % of the Kuwaiti adults had vitamin D inadequacy (25(OH)D = 12-19.9 ng/ml), and 27 % had vitamin D deficiency (25(OH)D < 12 ng/ml). The prevalences of prediabetes and diabetes were 40 and 27 %, respectively. Vitamin D inadequacy (OR = 1.7, 95 % CI: 1.0-2.9)...
Vitamin D deficiency has been contributed to type 2 diabetes and Metabolic Syndrome progression. The aim of this study was to see if there was an association between vitamin D and glucose, blood pressure, kidney biomarkers, lipid profiles in Iraqi type 2 diabetes patients. Also, compare the anthropometric and clinical parameters of diabetes in addition to vitamin D level between T2DM patients and healthy controls. This case-control study was conducted with 100 diabetic patients who visited The National Diabetes Center in Baghdad/Iraq. 100 healthy controls of students at Al-Nahrain University in Baghdad/Iraq. The period of study was from October 2018 to June 2019. After recording demographic and anthropometric factors, fasting blood and serum samples was taken to measure of blood glucose, HbA1c, Urea, creatinine, lipid profile and 25-hydroxyvitamin D3 (25-OHD3). The results showed that statistically significant differences between T2DM patients and healthy controls in BMI, FBG, HbA1c, 25(OH) D, and lipid profile levels (P≤ 0.005). The blood urea levels increase significantly in diabetes patients more than controls (P≤ 0.05). Vitamin D inversely associated with FBG (r =-0.236, P=0.028) and HbA1c (r = −0.303, P=0.0045). Vitamin D level, HDL and blood urea decreased significantly in T2DM patient's more than healthy controls. Furthermore, BMI, lipid profile, FBG and HbA1c increased significantly in T2DM patients higher than healthy controls. There is an inverse relationship between FBG and HbA1c concentration and the level of 25 (OH)-D in Iraqi patients with diabetes mellitus type 2.
A Study on Vitamin D Levels in Patients with Type II Diabetes compared to Normal Subjects
2015
Vitamin D deficiency is highly prevalent in the world and in Asian countries including Iran. There is a great deal of evidence suggesting the relationship between serum Vitamin D level and prevalence of type II diabetes. The objective of this study was to assess the serum level of Vit D in diabetics and non-diabetics and to compare the results of the two groups. This descriptive epidemiological study was carried out on 79 participants including 40 diabetic patients and 39 healthy individuals. The participants were randomly selected from the participants of the Ahwaz Metabolic Syndrome project. The serum vitamin D level, FBS, PTH, and insulin level were measured in the participants. The insulin resistance (HOMA-IR index) was also calculated for all participants. In general, 97.1% of healthy participants and 88.1% of diabetics were diagnosed with vitamin D deficiency or inadequacy. No difference was observed between the levels of vitamin D in the two groups (P=0.23). There was a stati...
Background: Type II diabetes is a chronic hyperglycemic disorder. Vitamin D appears to be associated with chronic disease prevention and modulation of immunity. This study was designed to associate vitamin D levels with glycemic control among type 2 diabetes mellitus in Khartoum state. Methods: This was a prospective case-control study conducted between June and November 2021 in Khartoum, Sudan. In total, 80 individuals were included in the study, of which 40 had type 2 diabetes mellitus, while the other 40 were normal, apparently healthy individuals. Vitamin D was measured by ELISA. Results: SPSS was used for statistical analysis. Results showed that 20% of case group (patients with diabetes mellitus) had suboptimal vitamin D levels, whereas 80% had vitamin D deficiency. Vitamin D levels were significantly decreased among the case group when compared to the control group (P-value = 0.00). The glycated hemoglobin was negatively correlated with vitamin D level (P-value = 0.017, R =-0.376). Conclusion: In this study, a significant decrease in vitamin D was seen among people with type 2 DM. There was a weak negative correlation between hemoglobin A1C and vitamin D level, and no significant difference in Vitamin D levels among gender and different types of treatment.
IRANIAN DIABETICS MAY NOT BE VITAMIN D DEFICIENT MORE THAN HEALTHY SUBJECTS
2000
There are some reports of decreased serum levels of 25(OH)D in the subjects with impaired glucose tolerance and type 2 diabetes mellitus (T2DM). To assess vitamin D status of the Iranian diabetics, a pilot study was conducted on 90 subjects with either type 1 diabetes mellitus (T1DM) (n= 30), T2DM (n= 30), or apparently healthy subjects (n= 30) during fall
Saudi medical journal, 2015
To determine whether 12-month, 2000IU/day vitamin D supplementation cardiometabolically improves treatment naïve type 2 diabetes mellitus (T2DM) Saudi patients with vitamin D deficiency. This 12-month interventional study was conducted at primary health centers in 5 different residential areas in Riyadh, Saudi Arabia between January 2013 and January 2014. Forty-five Saudi T2DM patients were enrolled. Baseline anthropometrics, glycemic, and lipid profiles were measured and repeated after 6 and 12 months. All subjects were provided with 2000IU vitamin D supplements for one year. Vitamin D deficiency at baseline was 46.7%, 31.8% after 6 months, and 35.6% after 12 months, indicating an overall improvement in the vitamin D status in the entire cohort. Insulin and homeostatic model assessment-insulin resistance (HOMA-IR) after 12 months were significantly lower than a 6 months (p less than 0.05), but comparable to baseline values. Mean levels of triglycerides increased overtime from ...
Association Of Vitamin D Status And Diabetes Mellitus
2012
To evaluate the association of 25-hydroxyvitamin D3 (25OHD)inadequacyand hyperglycaemia in a Pakistani adult population.Study Design:Case control studyPlace & Period of Study:Department of Pathology, PNS SHIFA Hospital, Karachi; Aug 2011 to Nov 2011.Method and Material:Plasma Glucose levels were measured in 86 patients divided on the basis of their 25-hydroxyvitamin D3(25OHD)levels in three groups, normal (>31 ng/ml), insufficient (20-31ng/ml) and deficient (<20ng/ml). Vitamin D insufficiency (VDI)and Vitamin D Deficiency (VDD) are collectively called Vitamin D inadequacy. 25OHD was measured by electrochemiluminescenceusing Roche Elecsys® Systems while glucose was estimated by routine methods on Roche Hitachi® Autoanalyser.Results:.Vitamin D levels were inversely correlated with plasma glucose levels(r=-0.38;p<0.01) with an Odd Ratio of 3.59(95%confidence interval 1.29 to 8.70).Fasting plasma glucose was significantly higher in VDD patientsas compared to patients withnormal...
ASSOCIATION OF VITAMIN D WITH TYPE 2 DIABETES MELLITUS IN KARACHI, PAKISTAN
Hypovitaminosis D has become a pandemic in the world populations and is believed to be related with the diabetes mellitus (DM). The aim of study was to assess the status of vitamin D along with other parameters in type 2 diabetic patients. Vitamin D (VD), calcium (Ca), phosphorous (Ph), random blood glucose (RBS) and HbA1c levels were assessed in 192 diabetic subjects. Hypovitaminosis D was prevalent in diabetic patients while, Ca and Ph levels were found in normal physiological range. RBS and HbA1c showed negative association with VD levels in vitamin D deficient and diabetic patients with good glycemic control.