Effect of a potent cyclooxygenase inhibitor, 5-ethyl-4-methoxy-2-phenylquinoline (KTC-5), on human platelets (original) (raw)

Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists

Bassem S H A B A N Sadek

Drug Design, Development and Therapy, 2015

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Measurement of arachidonic acid liberation in thrombin-stimulated human platelets. Use of agents that inhibit both the cyclooxygenase and lipoxygenase enzymes

Gerard Mauco

Biochimica et biophysica acta, 1985

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Role of arachidonic acid metabolism in human platelet activation and irreversible aggregation

Gundu Rao

American Journal of Hematology, 1985

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Inhibition of cyclooxygenase-independent platelet aggregation by low vitamin E concentration

Luigi Iuliano

Atherosclerosis, 1990

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Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets

Eduardo Lapetina

Proceedings of the National Academy of Sciences, 1979

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A role for cyclooxygenase products in the formation of phosphatidic acid in stimulated human platelets. Differential mechanisms of action of thrombin and collagen

W. Siess

The Journal of biological chemistry, 1983

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Pharmacologic Inhibition of Thromboxane Synthetase and Platelet Aggregation: Modulatory Role of Cyclooxygenase Products

giovanni de gaetano

1984

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Multifaceted effects of arachidonic acid and interaction with cyclic nucleotides in human platelets

Valentina Shpakova

Thrombosis Research, 2018

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Inhibition by sulfhydryl agents of arachidonic acid-induced platelet aggregation and release of potential inflammatory substances

Bernardo Vargaftig

Prostaglandins, 1974

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New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and cyclooxygenase-1 activity

Ali Khalaf

Chemistry Central Journal, 2012

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Effects on primary haemostasis of an anti-inflammatory agent with 5-lipoxygenase and cyclooxygenase inhibitory activity

Maria Valentina Perez Hernandez

Journal of cardiovascular medicine (Hagerstown, Md.), 2006

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Structural requirements for preventing the aspirin- and the arachidonate-induced inactivation of platelet cyclo-oxygenase: Additional evidence for distinct enzymatic sites

Bernardo Vargaftig

European Journal of Pharmacology, 1984

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Inhibition of release of arachidonic acid by monodansylcadaverine during activation of human platelets by collagen

Hwa-Jin Park

Agricultural and Biological Chemistry, 1986

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Effect of some cyclooxygenase inhibitors on the increase in guanosine 3′:5′-cyclic monophosphate induced by NO-donors in human whole platelets

Enrica Cecchi

British Journal of Pharmacology, 1998

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Aggregation and/or oxygenated products of arachidonic acid are not required for collagen-induced deacylation of phosphatidylcholine in human platelets

L. A . Piché

The Biochemical journal, 1989

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Effects of a trans isomer of arachidonic acid on rat platelet aggregation and eicosanoid production

jean-louis sebedio

The Journal of Lipid Research

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Arachidonic Acid Metabolism in Endothelial Cells and Platelets

Nazmul Islam

Annals of The New York Academy of Sciences, 1982

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Effect of GSH depletion by 1-chloro-2,4-dinitrobenzene on human platelet aggregation, arachidonic acid oxidative metabolism and cytoskeletal proteins

GianPiero Pescarmona

Thrombosis Research, 1985

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12(S)-Hydroperoxy-eicosatetraenoic acid increases arachidonic acid availability in collagen-primed platelets

Michel Lagarde

Journal of Lipid Research

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Effect of eicosatetraenyl (3-aminopropyl) phosphonate (URI-73A) on platelet aggregation and arachidonic acid metabolism

Raffaele Landolfi

Prostaglandins, …, 1983

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Modulation of platelet function by reactive oxygen metabolites

Giuseppe Ambrosio

1994

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Aspirin enhances the sensitivity of human platelet 12-lipoxygenase to inhibition by 15-hete, an endogenous regulator

Jack Vanderhoek

Prostaglandins, Leukotrienes and Medicine, 1985

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Comparison of the in vitro effect of eicosapentaenoic acid (EPA)-derived lipoxygenase metabolites on human platelet function with those of arachidonic acid

Mitsuko Takenaga

Thrombosis Research, 1986

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Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events

John Pepper

The FASEB Journal, 2006

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In vitro effects of aspirin and non steroidal anti-inflammatory drugs on the formation of 12-hydroxyeicosatetraenoic acid by platelets

A. Eynard

Prostaglandins, Leukotrienes and Medicine, 1986

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