The thermal/pH-sensitive drug delivery system encapsulated by PAA based on hollow hybrid nanospheres with two silicon source (original) (raw)
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ACS Omega
In the current report, hollow mesoporous silica (HMS) nanoparticles were successfully prepared by means of a hard-templating method and further modified with poly(styrene sulfonate) (PSS) via radical polymerization. Structural analysis, surface spectroscopy, and thermogravimetric characterization confirmed a successful surface modification of HMS nanoparticles. A hairy PSS was clearly visualized by high-resolution transmission electron microscopy measurement, and it is grown on the surface of HMS nanoparticles. The Brunauer− Emmett−Teller surface area and average pore size of HMS nanoparticles were reduced after surface modification because of the pore-blocking effect, which indicated that the PSS lies on the surface of nanoparticles. Nevertheless, the PSS acts as a "nano-gate" to control the release of curcumin which is triggered by pH. The drug-release profile of unmodified HMS nanoparticles showed a stormed release in both pH 7.4 and 5.0 of phosphate buffer saline buffer solution. However, a slow release (9.92% of cumulative release) of curcumin was observed at pH 7.4 when the surface of HMS nanoparticles was modified by PSS. The kinetic release study showed that the curcumin release mechanism from PSS@HMS nanoparticles followed the Ritger−Peppas kinetic model, which is the non-Fickian diffusion. Therefore, the PSS-decorated HMS nanoparticles demonstrate potential for pH-triggered drug release transport.
Journal of colloid and interface science, 2014
Hollow mesoporous silica nanoparticles (HMSNs) are one of the most promising carriers for effective drug delivery due to their large surface area, high volume for drug loading and excellent biocompatibility. However, the non-ionic surfactant templated HMSNs often have a broad size distribution and a defective mesoporous structure because of the difficulties involved in controlling the formation and organization of micelles for the growth of silica framework. In this paper, a novel "Eudragit assisted" strategy has been developed to fabricate HMSNs by utilising the Eudragit nanoparticles as cores and to assist in the self-assembly of micelle organisation. Highly dispersed mesoporous silica spheres with intact hollow interiors and through pores on the shell were fabricated. The HMSNs have a high surface area (670m(2)/g), small diameter (120nm) and uniform pore size (2.5nm) that facilitated the effective encapsulation of 5-fluorouracil within HMSNs, achieving a high loading ca...
Colloids and Surfaces B Biointerfaces, 2007
Core-shell nanoparticles of Au@silica with a diameter of approximate 45-60 nm and wall thickness in range of 3-10 nm were synthesized by using 40 and 50 nm gold nanoparticles as the templates. The mesoporous particles are regulated by 3-aminopropyltrimethoxysilane addition. Hollow mesoporous silica nanocapsules (HMSNs) were prepared by using sodium cyanide to dissolve the gold cores. The characterization of Au@silica and HMSNs by transmission electronic microscope indicated that the silica shells were uniform and smooth, and also the porosity was proved by fluorescein isothiocyanate (FITC) release experiments. The ratio of hollow core to HMSNs is more than 70%. HMSNs were subsequently used as drug carrier to investigate FITC (as a model drug) release behaviors in vitro. Fluorescent spectrometry was performed to determine the release kinetics from the HMSNs. The release profiles are significantly different as compared with the control (free FITC), which show that HMSNs are good drug carriers to control drug release, and have high potential in therapeutic drugs delivery in future applications.
The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity
Processes, 2019
As a promising candidate for expanding the capacity of drug loading in silica nanoplatforms, hollow mesoporous silica nanoparticles (HMSNs) are gaining increasing attention. In this study, porous nanosilica (PNS) and HMSNs were prepared by the sol-gel method and template assisted method, then further used for Rhodamine (RhB) loading. To characterize the as-synthesized nanocarriers, a number of techniques, including X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption-desorption isotherms, dynamic light scattering (DLS), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FTIR) were employed. The size of HMSN nanoparticles in aqueous solution averaged 134.0 ± 0.3 nm, which could be adjusted by minor changes during synthesis, whereas that of PNS nanoparticles was 63.4 ± 0.6 nm. In addition, the encapsulation of RhB into HMSN nanoparticles to form RhB-loaded nanocarriers (RhB/HMSN) was successful, achieving high loading efficie...
ACS Applied Nano Materials, 2022
The development of nanocomposite supramolecular hydrogels which can be activated by local or external stimuli (pH, redox, enzyme, heat) is highly promising for various applications including implantable materials for anti-tumor or tissue engineering applications. Here, we show that large pore stellate mesoporous silica modified with isobutyramide grafts, allow >100% wt. loading of enzymes which ensures through the enzyme-assisted self-assembly 2 an easy, rapid and efficient way to design smart thermoresponsive nanocomposite supramolecular hydrogels. Typical temperature increase (42°C), which may be induced by hyperthermia anti-cancer treatments, leads to the controlled-release of doxorubicin encapsulated in the resulting peptide self-assembled material.
Carboxylic modified spherical mesoporous silicas аs drug delivery carriers
International journal of pharmaceutics, 2012
The present study deals with the development and functionalization of mesoporous silica nanoparticles as drug delivery platforms. Spherical MCM-41 and SBA-15 silicas with different pore sizes (2.7 nm and 5.5 nm, respectively) were post-synthesis modified applying a new, two step process. The initial step was the modification with 3-amino-propyltriethoxysilane, and the next was the reaction with succinic anhydride in toluene in order to obtain carboxylic modified mesoporous carriers. The carboxylic-functionalized mesoporous materials were characterized by XRD, nitrogen physisorption, TEM, ATR FT-IR spectroscopy. The successful carboxylic functionalization was proved by the changes of the zeta potential of the mesoporous materials before and after modification. The parent and the carboxylic-modified MCM-41 and SBA-15 materials showed high adsorption capacity (approximately 50 wt.%, except for non-functionalized MCM-41) for sulfadiazine that possesses amino functional groups. Mesoporou...
RSC Advances, 2018
Hollow mesoporous silica capsules (HMSC) are potential drug transport vehicles due to their biocompatibility, high loading capacity and sufficient stability in biological milieu. Herein, we report the synthesis of ellipsoid-shaped HMSC (aspect ratio 2)performedusinghematiteparticlesassolidtemplatesthatwerecoatedwithaconformalsilicashellthroughcross−condensationreactions.Forobtaininghollowsilicacapsules,theironoxidecorewasremovedbyacidicleaching.GassorptionstudiesonHMSCrevealedmesoscopicpores(mainporewidth2) performed using hematite particles as solid templates that were coated with a conformal silica shell through cross-condensation reactions. For obtaining hollow silica capsules, the iron oxide core was removed by acidic leaching. Gas sorption studies on HMSC revealed mesoscopic pores (main pore width 2)performedusinghematiteparticlesassolidtemplatesthatwerecoatedwithaconformalsilicashellthroughcross−condensationreactions.Forobtaininghollowsilicacapsules,theironoxidecorewasremovedbyacidicleaching.GassorptionstudiesonHMSCrevealedmesoscopicpores(mainporewidth38Å) and a high surface area of 308.8 m 2 g À1. Cell uptake of dye-labeled HMSC was confirmed by incubating them with human cervical cancer (HeLa) cells and analyzing the internalization through confocal microscopy. The amphiphilic nature of HMSC for drug delivery applications was tested by loading antibiotic (ciprofloxacin) and anticancer (curcumin) compounds as model drugs for hydrophilic and hydrophobic therapeutics, respectively. The versatility of HMSC in transporting hydrophilic as well as hydrophobic drugs and a pH dependent drug release over several days under physiological conditions was demonstrated in both cases by UV-vis spectroscopy. Ciprofloxacin-loaded HMSC were additionally evaluated towards Gram negative (E. coli) bacteria and demonstrated their efficacy even at low concentrations (10 mg ml À1) in inhibiting complete bacterial growth over 18 hours.
Hollow Silica Nanocontainers as Drug Delivery Vehicles
Langmuir, 2008
Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe 3 O 4 nanocrystals, as templates. The core cavity was obtained by removal of Fe 3 O 4 phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.
Ceramics International, 2017
Hollow mesoporous silica nanoparticles have emerged as attractive drug delivery carriers. In this work, we report successful synthesis of hollow mesoporous silica nanoparticles (HMSNs) using poly tert-butyl acrylate (PtBA) nanospheres as hard templates and CTAB as structure directing agent for loading sulfasalazine into its porous structure. The samples were synthesized using PtBA; sodium dodecyl sulfate (SDS)-in an aqueous solution of CTAB and tetraethylorthosilicate (TEOS) as the inorganic precursor. Two different methods were utilized to remove organic phases including calcination, and acidic/basic ethanolic solvent extraction approach. For the latter, microstructural studies using SEM and N 2 porosimetery revealed the formation of highly uniform mono-dispersed particles of sphere morphology (~130 nm) with the high specific surface area (1501 m 2 /g) and mean pore size of ~2.6 nm. However, rather deformed and aggregated sphere-like particles were obtained for the calcined samples. TEM examinations also 2 confirmed the formation of 20-30 nm thick walls for the prepared HMSNs particles. Further, HMSN samples treated by solvent extraction method were functionalized by 3-aminopropyl triethoxysilane (APTS) compound for drug delivery. DTA/TG analysis showed that the total amount of loaded sulfasalazine drug was 5.1 wt%.