A Nanotechnology-Based Approach to Biosensor Application in Current Diabetes Management Practices (original) (raw)

Recent Progress in Nanobiosensors for Precise Detection of Blood Glucose Level

Biochemistry Research International

Diabetes mellitus (DM) follows a series of metabolic diseases categorized by high blood sugar levels. Owing to the increasing diabetes disease in the world, early diagnosis of this disease is critical. New methods such as nanotechnology have made significant progress in many areas of medical science and physiology. Nanobiosensors are very sensible and can identify single virus particles or even low concentrations of a material that can be inherently harmful. One of the main factors for developing glucose sensors in the body is the diagnosis of hypoglycemia in individuals with insulin-dependent diabetes. Therefore, this study aimed to evaluate the most up-to-date and fastest glucose detection method by nanosensors and, as a result, faster and better treatment in medical sciences. In this review, we try to explore new ways to control blood glucose levels and treat diabetes. We begin with a definition of biosensors and their classification and basis, and then we examine the latest bios...

Applications of nanotechnology in diabetes

Digest Journal of …, 2008

Nanotechnology offers sensing technologies that provide more accurate and timely medical information for diagnosing disease, and miniature devices that can administer treatment automatically if required. Some tests such as diabetes blood sugar levels require patients to administer the test themselves to avoid the risk of their blood glucose falling to dangerous levels. Certain users such as children and the elderly may not be able to perform the test properly, timely or without considerable pain. Nanotechnology can now offers new implantable and/or wearable sensing technologies that provide continuous and extremely accurate medical information.The purpose of this review is to throw more light on the recent advances and impact of nanotechnology on biomedical sciences to cure diabetes.

Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Diabetes

Nanotechnology is a field encompassing nanostructures, nanomaterials and nanoparticles, which are of increasing importance to researchers and industrial players alike. Nanotechnology addresses the construction and consumption of substances and devices on the nanometer scale. Nanomedicine is a new field that combines nanotechnology with medicine to boost human health care. Nanomedicine is an interdisciplinary field that includes various areas of biology, chemistry, physics and engineering. The most important problems related to diabetes management, such as self-monitoring of blood glucose levels and insulin injections, can now be conquered due to progress in nanomedicine, which offers glucose nanosensors, the layer-by-layer technique, carbon nanotubes, quantum dots, oral insulins, microspheres, artificial pancreases and nanopumps. In this review, the key methodological and scientific characteristics of nanomedicine related to diabetes treatment, glucose monitoring and insulin administration are discussed

Nanotechnology in Diagnosis and Treatment of Diabetes Mellitus: Review

2021

Customary techniques for diabetes management require steady and tedious glucose monitoring (GM) and insulin infusions, affecting quality of life. The worldwide diabetic population is required to increment to 439 million, with roughly US$490 billion in medical services consumptions by 2030, forcing a huge trouble on medical care systems around the world. Ongoing advances in nanotechnology have arisen as promising elective methodologies for the management of diabetes. For instance, implantable nano sensors are being created for nonstop GM, new nanoparticle (NP)- based imaging approaches that evaluate subtle changes in β cell mass can encourage early diagnosis, and nano technology-based insulin delivery strategies are being investigated as novel treatments. Here, we give an all-encompassing rundown of this quickly propelling field gathering all viewpoints relating to the management of diabetes.

Nanomaterial-mediated Biosensors for Monitoring Glucose

Journal of Diabetes Science and Technology, 2014

Real-time monitoring of physiological glucose transport is crucial for gaining new understanding of diabetes. Many techniques and equipment currently exist for measuring glucose, but these techniques are limited by complexity of the measurement, requirement of bulky equipment, and low temporal/spatial resolution. The development of various types of biosensors (eg, electrochemical, optical sensors) for laboratory and/or clinical applications will provide new insights into the cause(s) and possible treatments of diabetes. State-of-the-art biosensors are improved by incorporating catalytic nanomaterials such as carbon nanotubes, graphene, electrospun nanofibers, and quantum dots. These nanomaterials greatly enhance biosensor performance, namely sensitivity, response time, and limit of detection. A wide range of new biosensors that incorporate nanomaterials such as lab-on-chip and nanosensor devices are currently being developed for in vivo and in vitro glucose sensing. These real-time ...

Trends in Nanomaterial-Based Non-Invasive Diabetes Sensing Technologies

Diagnostics, 2014

Blood glucose monitoring is considered the gold standard for diabetes diagnostics and self-monitoring. However, the underlying process is invasive and highly uncomfortable for patients. Furthermore, the process must be completed several times a day to successfully manage the disease, which greatly contributes to the massive need for non-invasive monitoring options. Human serums, such as saliva, sweat, breath, urine and tears, contain traces of glucose and are easily accessible. Therefore, they allow minimal to non-invasive glucose monitoring, making them attractive alternatives to blood measurements. Numerous developments regarding noninvasive glucose detection techniques have taken place over the years, but recently, they have gained recognition as viable alternatives, due to the advent of nanotechnology-based sensors. Such sensors are optimal for testing the amount of glucose in serums other than blood thanks to their enhanced sensitivity and selectivity ranges, in addition to their size and compatibility with electronic circuitry. These nanotechnology approaches are rapidly evolving, and new techniques are constantly emerging. Hence, this manuscript aims to review current and future nanomaterial-based technologies utilizing saliva, sweat, breath and tears as a diagnostic medium for diabetes monitoring.

Nanosensors for continuous monitoring glucose in diabetes

2014

Most of the work done up to-date in the Republic of Macedonia concerning the nanostructures is carried out at the Faculty of Technology and Metallurgy, Ss. Cyril and Methodius University, Skopje. A research team at the Faculty has achieved notable results in the field of polymer-based composites and nanostructured materials. One of their recent researches was on the design and processing of organic multi nanocomposites for sensors aimed to detect low level of chemical agents (gases) in environmental monitoring. Since polymer nanocomposite films with functionalized MWCNTs exhibit a large surface-to-volume ratio and unique chemical, optical, and electrical properties; they are a very attractive class of materials for various applications. Furthermore, their functionalization offer new potentials associated with their specific interactions. Biocompatible polymer matrices poly (methyl methacrylate) (PMMA) and polycaprolactone (PCL) were used to provide good interfacial bonding between c...

Nano-Engineered Biomimetic Optical Sensors for Glucose Monitoring in Diabetes

Sensors, 2016

Diabetes is a rapidly growing disease that can be monitored at an individual level by controlling the blood glucose level, hence minimizing the negative impact of the disease. Significant research efforts have been focused on the design of novel and improved technologies to overcome the limitations of existing glucose analysis methods. In this context, nanotechnology has enabled the diagnosis at the single cell and molecular level with the possibility of incorporation in advanced molecular diagnostic biochips. Recent years have witnessed the exploration and synthesis of various types of nanomaterials with enzyme-like properties, with their subsequent integration into the design of biomimetic optical sensors for glucose monitoring. This review paper will provide insights on the type, nature and synthesis of different biomimetic nanomaterials. Moreover, recent developments in the integration of these nanomaterials for optical glucose biosensing will be highlighted, with a final discussion on the challenges that must be addressed for successful implementation of these nano-devices in the clinical applications is presented.

Review of the Recent Advances in Nano-Biosensors and Technologies for Healthcare Applications

Chemistry Proceedings, 2021

The growing human population and the discovery of new diseases and emerging pandemics have increased the need for healthcare treatments and medications with innovative designs. The emergence of nanotechnology provides a platform for novel diagnostic and therapeutic in vivo non-invasive detection and treatment of ailments. It is now the era of the Internet of things (IoT), and data acquisition and interpretation from various parts of the human body in real time is possible with interconnected sensors and information transfer devices. Miniaturization, low power consumption and price with compatibility to existing network circuits are essential requirements in the IoT. Biosensors made of nanostructured materials are the ideal choice due to the unique structural, chemical and electronic properties of these materials with the advantage of a large surface-to-volume ratio, which makes them very successful for use as sensors for the detection of diseases, drug carriers, filters, fillers and...