Evolving paradigms on the interplay of mitochondrial Hsp70 chaperone system in cell survival and senescence (original) (raw)

Understanding the functional interplay between mammalian mitochondrial Hsp70 chaperone machine components

Balasubramanyam Chittoor

Journal of Biological Chemistry, 2010

View PDFchevron_right

Understanding the Role of the HSP70 Molecular Chaperone Family in Maintaining Protein Homeostasis

Michael Schieber, Cindy Voisine, Sally Mcfall

2000

View PDFchevron_right

Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's disease

Madhuja Samaddar

Human Molecular Genetics, 2012

View PDFchevron_right

Roles of Intramolecular and Intermolecular Interactions in Functional Regulation of the Hsp70 J-protein Co-Chaperone Sis1

Maciej Baranowski

Journal of molecular biology, 2015

View PDFchevron_right

Chaperone networks: Tipping the balance in protein folding diseases

Cindy Voisine

Neurobiology of Disease, 2010

View PDFchevron_right

Molecular Chaperones Hsp90 and Hsp70 Deliver Preproteins to the Mitochondrial Import Receptor Tom70

jason young

Cell, 2003

View PDFchevron_right

Multiple 40-kDa Heat-Shock Protein Chaperones Function in Tom70-dependent Mitochondrial Import

jason young

Molecular Biology of The Cell, 2007

View PDFchevron_right

Targeting Chaperone/Co-Chaperone Interactions with Small Molecules: A Novel Approach to Tackle Neurodegenerative Diseases

rajnish kumar

Cells

View PDFchevron_right

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

Bonnie Berger

Cell, 2014

View PDFchevron_right

Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks

Angela Brice

Cell Reports, 2014

View PDFchevron_right

Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60

Renu Wadhwa, S. Meirinho

Biochemical Journal, 2005

View PDFchevron_right

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

Lila Gierasch

Journal of molecular biology, 2015

View PDFchevron_right

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity

Cindy Voisine

Disease Models & Mechanisms, 2016

View PDFchevron_right

Identification of Elements That Dictate the Specificity of Mitochondrial Hsp60 for Its Co-Chaperonin

Peter Lund

PLoS ONE, 2012

View PDFchevron_right

Comprehensive identification of HSP70/HSC70 Chaperone Clients in Human Cells

Tanya Paull

2019

View PDFchevron_right

Development of GMP-1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer's disease

Manfred Windisch

Journal of cellular and molecular medicine, 2018

View PDFchevron_right

Impaired Interdomain Communication in Mitochondrial Hsp70 Results in the Loss of Inward-directed Translocation Force

Matthias P Mayer

Journal of Biological Chemistry, 2008

View PDFchevron_right

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone

Svetlana Konovalova

Redox biology, 2018

View PDFchevron_right

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

R. Morimoto

Genes & Development, 2008

View PDFchevron_right

Multilevel interaction of the DnaK/DnaJ(HSP70/HSP40) stress-responsive chaperone machine with the central metabolism

Mickael Dinclaux

Scientific Reports

View PDFchevron_right

Selective Induction of Mitochondrial Chaperones in Response to Loss of the Mitochondrial Genome

Ryan Martinus

European Journal of Biochemistry, 1996

View PDFchevron_right

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

Vania Prado

Frontiers in Neuroscience, 2017

View PDFchevron_right

Molecular chaperones in protein folding and proteostasis

Manajit Hayer-Hartl

Nature, 2011

View PDFchevron_right

The Link That Binds: The Linker of Hsp70 as a Helm of the Protein’s Function

Tawanda Zininga

Biomolecules, 2019

View PDFchevron_right

Multistep mechanism of substrate binding determines chaperone activity of Hsp70

Stefan Rüdiger

Nature Structural Biology, 2000

View PDFchevron_right

Multi-Chaperones-Interactors Network in Mitochondria (MtCIN): Its Role in Carcinogenesis and Methodology of Analysis

Anna M. Czarnecka

View PDFchevron_right

Late onset motoneuron disorder caused by mitochondrial Hsp60 chaperone deficiency in mice

Francesca Maltecca

Neurobiology of Disease, 2013

View PDFchevron_right

Molecular Chaperones and Associated Cellular Clearance Mechanisms against Toxic Protein Conformers in Parkinson’s Disease

dj cuervo q

Neurodegenerative Diseases, 2011

View PDFchevron_right

Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α-synuclein complex by Hip

Carlos Bertoncini

Embo Journal, 2009

View PDFchevron_right

Mechanism of Action of Chaperones in Protein Function

Sakariyau A . Waheed

World News of Natural Sciences, 2022

View PDFchevron_right

Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90

Bliss Chang

View PDFchevron_right

Binding of a Small Molecule at a Protein-Protein Interface Regulates the Chaperone Activity of Hsp70-Hsp40

srikanth patury

Acs Chemical Biology, 2010

View PDFchevron_right

Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis

G. Marius Clore FRS

Proceedings of the National Academy of Sciences

View PDFchevron_right

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

Sahil Sharma

Cell Reports, 2020

View PDFchevron_right