Aqueous Hydrofluoric Acid Catalyzed Facile Synthesis of 2,3,6-Substituted Quinoxalines (original) (raw)
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Molecules
Quinoxalines, a class of N-heterocyclic compounds, are important biological agents, and a significant amount of research activity has been directed towards this class. They have several prominent pharmacological effects like antifungal, antibacterial, antiviral, and antimicrobial. Quinoxaline derivatives have diverse therapeutic uses and have become the crucial component in drugs used to treat cancerous cells, AIDS, plant viruses, schizophrenia, certifying them a great future in medicinal chemistry. Due to the current pandemic situation caused by SARS-COVID 19, it has become essential to synthesize drugs to combat deadly pathogens (bacteria, fungi, viruses) for now and near future. Since quinoxalines is an essential moiety to treat infectious diseases, numerous synthetic routes have been developed by researchers, with a prime focus on green chemistry and cost-effective methods. This review paper highlights the various synthetic routes to prepare quinoxaline and its derivatives, cove...
Synthesis, Reactions and Biological Activity of Quinoxaline Derivatives
American journal of organic chemistry, 2015
The review deals with synthesis and reactions of quinoxaline derivatives as well as their diverse pharmacological and biological properties. Quinoxalines and fused ring systems show diverse pharmacological activities. Syntheses of quinoxaline derivatives via many different methods of synthetic strategies have been presented.
Synthesis and Reactions of Quinoxalines
INFLIBNET, 1990
INTRODUCTION 14 yielding 2-D-arabino tetrahydroxybutyl quinoxaline (21). HOAc CH~ Similarly, o-phenylenediamine and dehydro ascorbic acid 15 condense giving 2-hydroxy-3-(11-oxo-2 ' ,3' ,4 '-trihydroxybutyl)quinoxaline (22). 2.2.2 Intramolecular cyclisation reactions Cyclisation of o<.-amino acid intermediates formed from the amino acid and an o-nitrohalogenobenzene is an
Fast and green synthesis of biologically important quinoxalines with high yields in water
Current Chemistry Letters, 2014
Optimal method were developed for the green synthesis of quinoxaline derivatives based on the highly efficient and simple condensation reaction of various aromatic 1,2-diketones and 1,2diamines in nearly quantitative yields in water. In this method we did not use any catalyst. The very mild reaction conditions, the high yields of the products, and the absence of any catalyst make this methodology an efficient and green route for synthesis of quinoxalines.
An Efficient Solid Acid Promoted Synthesis of Quinoxaline Derivatives at Room Temperature
Chinese Journal of Chemistry, 2007
Quinoxaline derivatives have been synthesized in a very short time with excellent yields by the condensation of 1,2-diamines with aliphatic or aromatic 1,2-dicarbonyl compounds or benzilmonoxime in the presence of silica sulfuric acid as a very inexpensive solid acid catalyst at room temperature. The recovery and reuse of the catalyst are also satisfactory.
Molecules, 2008
The unexpected substitution of fluorine atoms and phenoxy groups attached to quinoxaline or benzofuroxan rings is described. The synthesis of 2-benzyl-and 2-phenoxy-3-methylquinoxaline 1,4-di-N-oxide derivatives was based on the classical Beirut reaction. The tendency of fluorine atoms linked to quinoxaline or benzofuroxan rings to be replaced by a methoxy group when dissolved in an ammonia saturated solution of methanol was clearly demonstrated. In addition, 2-phenoxyquinoxaline 1,4-di-N-oxide derivatives became 2-aminoquinoxaline 1,4-di-N-oxide derivatives in the presence of gaseous ammonia.