Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease
Roxana A Radu
Proceedings of the National Academy of Sciences of the United States of America, 2017
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Oxidative Stress Sensitizes Retinal Pigmented Epithelial (RPE) Cells to Complement-mediated Injury in a Natural Antibody-, Lectin Pathway-, and Phospholipid Epitope-dependent Manner
Kusumam Joseph
Journal of Biological Chemistry, 2013
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Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress OPEN
Pete J Gardner
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Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes
Roxana A Radu
2020
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A Novel Role of Complement in Retinal Degeneration
Minzhong Yu
Investigative Ophthalmology & Visual Science, 2012
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Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration
Roxana A Radu
Proceedings of the National Academy of Sciences
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Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy
Mike Reichelt
Scientific Reports, 2018
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Complement System Dysregulation and Inflammation in the Retinal Pigment Epithelium of a Mouse Model for Stargardt Macular Degeneration
Roxana A Radu
Journal of Biological Chemistry, 2011
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Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium
So Ra Kim
Proceedings of The National Academy of Sciences, 2006
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Molecular Response of Chorioretinal Endothelial Cells to Complement Injury: Implications for Macular Degeneration
Shemin Zeng
The Journal of pathology, 2015
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Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9
John Greenwood
Journal of immunology (Baltimore, Md. : 1950), 2015
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Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy
Christine Curcio
Experimental Eye Research, 2011
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Targeting the Complement Cascade for Treatment of Dry Age-Related Macular Degeneration
Harris Ahmed
Biomedicines
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Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid
Heping Xu
Molecular vision, 2011
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Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration
Inderjeet Kaur
2014
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Complement in age-related macular degeneration: a focus on function
anne hughes
Eye, 2011
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Complement Component 1Q (C1Q) Upregulation in Retina of Murine, Primate, and Human Glaucomatous Eyes
Kali Stasi
Investigative Opthalmology & Visual Science, 2006
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Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma
Ruslana Tytarenko, Puran Bora
Molecular Immunology, 2011
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Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina
Anthony Day
Journal of Biological Chemistry, 2010
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Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis
Francesca Cordeiro
Apoptosis, 2015
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Analysis of Complement Expression in Light-Induced Retinal Degeneration: Synthesis and Deposition of C3 by Microglia/Macrophages Is Associated with Focal Photoreceptor Degeneration
Peter Kozulin, Matt Rutar, Paul Gatenby, Krisztina Valter
Investigative Ophthalmology & Visual Science, 2011
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The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited
Ethan Lai
Progress in Retinal and Eye Research, 2010
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Oxidative Stress Increases Endogenous Complement-Dependent Inflammatory and Angiogenic Responses in Retinal Pigment Epithelial Cells Independently of Exogenous Complement Sources
Joachim Wegener
Antioxidants, 2019
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4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells
Priyali Saxena
Chemical Research in Toxicology, 2018
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Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration
Krisztina Valter
Investigative Opthalmology & Visual Science, 2017
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Targeting the complement system for the management of retinal inflammatory and degenerative diseases
Heping Xu
European journal of pharmacology, 2016
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