Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes (original) (raw)
Related papers
2016
Aim: To investigate the role of postprandial triglyceride levels and its relation with carotid intima media thickness in patients with type 2 diabetes mellitus. Methods: This is a case-control study which comprises 50 patients of age between 40 and 60 years with type 2 diabetes mellitus of more than or equal to 3 years duration. Carotid artery Doppler was done by B-mode ultrasonography using a 7.5MHz transducer. Blood samples were obtained after an overnight fast (12 hours) for total cholesterol, Fasting triglyceride, HDL, LDL, VLDL levels, which are measured by standard laboratory technique. Then patients ate a standard meal that had a total energy of 9 Kcal/Kg with 60-65% of this energy being supplied by carbohydrate, 15-20% by protein and 20% by fat after taking insulin or oral hypoglycemic agent. Blood samples were taken again 4 hours after the meal for postprandial triglyceride level. Results: Patients were divided into three groups. The first group normo-normo (NN) group i.e p...
Diabetes Research and Clinical Practice, 2005
Hypertriglyceridemia is an important risk factor for coronary heart disease (CHD) and in the development of atherosclerosis, especially in subgroups of the population like those with type 2 diabetes. Although triglycerides are generally increased in the postprandial period, the association between postprandial triglyceride (ppTG) levels and atherosclerosis has not been investigated in north Indian type 2 diabetic subjects known to have a very high prevalence rate of premature CHD and insulin resistance. To investigate the role of ppTG levels in atherosclerosis in type 2 diabetes, we examined the correlation between ppTG levels and carotid intima-media thickness (IMT). Carotid IMT was determined by high resolution B-mode ultrasonography in 86 newly detected type 2 diabetic subjects (1-12 months duration) having good glycemic control (HbA 1C < 7%) and 45 non-diabetic subjects matched according to age and body mass index (BMI). Plasma glucose, insulin, total cholesterol, LDLcholesterol, HDL-cholesterol and triglycerides were measured after overnight fasting. Plasma insulin and glucose were also measured 2 h and plasma triglycerides 4 h after breakfast. The mean carotid IMT in diabetic subjects was higher than those in non-diabetic subjects (0.77 AE 0.15 mm versus 0.53 AE 0.16 mm, P < 0.001). Based on the fasting and postprandial triglyceride levels, the diabetic subjects were divided into three groups: normo-normo (NN); normo-hyper (NH); hyper-hyper (HH) [NN: fTG < 1.70 mmol/L and ppTG < 2.30 mmol/L; NH: fTG < 1.70 mmol/L and ppTG > 2.30 mmol/L; HH: fTG > 1.70 mmol/L and ppTG > 2.30 mmol/L]. Carotid IMT was significantly increased in the NH (0.79 AE 0.09 mm) and HH (0.82 AE 0.06 mm) groups compared with the NN group (0.59 AE 0.09 mm, P < 0.001). Although ppTG, age, fasting LDL-cholesterol, HOMAestimated insulin resistance, HbA 1C were all independently correlated with carotid IMT, age and ppTG levels had the strongest statistical influence (P < 0.002). #
Journal of Advances in Internal Medicine, 2018
Background and aim: Type 2 diabetes mellitus is associated with the development of premature arteriosclerosis and a higher cardiovascular morbidity and mortality. Diabetic dyslipidaemia is believed to play an important role in the pathogenesis of accelerated atherosclerosis in this condition. B-mode ultrasound enables non-invasive, direct visualization of the arterial wall. The aim of this study was to correlate intima media thickness of the carotid artery (CIMT) quantification as a reliable marker of atherosclerotic burden in diabetes patients.Method: It was a Cross Sectional Study done on 50 patients in the age group of 30-70 years with type II Diabetes Mellitus of more than 5 years duration without hypertension. Carotid Intima Media Thickness (CIMT) was measured using an echotomographic system with a 7.5-MHz linear transducer probe. With the carotid bulb and the longitudinal projection of the common carotid artery 2cmx from carotid bulb, the site of the greatest thickness includi...
Scholars journal of applied medical sciences, 2020
Original Research Article Background: Type-2 Diabetes Mellitus (T2DM) with cardiometabolic risk factors poses the high risk of atherosclerosis. The Intima-Media Thickness (IMT) of carotid artery is reliable indicator of cardiovascular diseases. Aims and objectives: To study the Correlation of Serum Triglyceride level with Carotid Intima-Media Thickness (CIMT) in Type-2 Diabetes Mellitus patients. Materials and Methods: Presentretrospective study was performed on 250 T2DM patients at Department of Medicine, Gandhi Medical College and associated Hamidia Hospital from January 2018 to March 2019. T2DM patients having age 25-65 were enrolled. CIMT was measured with ultrasonography and its correlation was checked with triglyceride serum level. Results: Out of 250, 152 were male and 98 were females. Mean age of cohorts was 53.03 years. out of 250 subjects only 79 has normal fasting triglyceride (FTG) and post prandial triglyceride (PPTG) (mean CIMT was 0.95±0.27), 88 subjects has abnormal PPTG and normal FTG with (mean CIMT 1.63±0.40 mm) and 83 subjects had abnormal FTG and PPTG i.e. ≥150 mg/dl and significantly high CIMT as 1.96±0.61 mm. Conclusion: FTG and PPTG levels are significantly correlated with the carotid intima media thickness. PPTG is indecently and strongly associated with CIMT.
https://www.ijrrjournal.com/IJRR\_Vol.7\_Issue.8\_Aug2020/Abstract\_IJRR0041.html, 2020
Objectives: Study Of Correlation Of Postprandial Lipid Profile With Carotid Intima Media Thickness In Type-II Diabetes Mellitus. Material and Methods: 30 type-2 diabetic patients and 30 healthy non diabetic control subjects will be taken from indoor wards of medicine department. American Diabetes Association Guidelines will be followed to diagnose diabetes episode of cerebrovascular diseases or intracranial space-occupying lesions were excluded. The collected data were analyzed using appropriate statistical test between the variables. Results: The mean Carotid Intima Media Thickness (CIMT) value were found to be raised in diabetic(1.00+-.489) as compared to healthy subjects(.43+-.02) signifying that Type-2 DM is associated with raised CIMT values. Raised CIMT(>0.8mm) was found in 14(46.7%) in diabetic patients as compared to 3(10%) in healthy. Conclusion: Carotid Intima Medial Thickness which is a marker of atherosclerosis and predictor of unfavourable cerebrovascular events which are important cause of morbidity and mortality, is raised in Type-2 DM patients especially those having abnormal fasting and postprandial dyslipidemia, .
Journal of Evolution of Medical and Dental Sciences, 2016
BACKGROUND Atherosclerosis is a leading cause of mortality in developed and developing nations. It forms the major determinant in the reduction of volume of vascular lumen in various parts of the blood vessel. Atherosclerosis and diabetes mellitus has major relations. Diabetic population is expected to reach an epidemic proportion not only in India but in many countries around the world which in turn has greatly accelerated the risk for cardiovascular diseases and early mortality. In another two decades, cardiovascular diseases complicated by atherosclerosis will be the major cause of death. Carotid intimal medial thickness measurement can serve as an early predictor of subclinical atherosclerosis. The purpose of this study was to evaluate the usefulness of measuring Carotid intimal medial thickness (CIMT) in predicting the subclinical atherosclerosis. AIMS AND OBJECTIVES To estimate subclinical atherosclerosis in patients with type 2 diabetes mellitus by measuring the carotid intimal medial thickness. To study the association of age, sex, body mass index, smoking, alcohol, duration of diabetes, hypertension, fasting hyperglycaemia, serum total cholesterol with the carotid intimal medial thickness. MATERIALS AND METHODS This study was carried out in a tertiary care hospital over a period of 6 months after obtaining Institutional Ethical Committee approval. Fifty patients who presented with history of type 2 diabetes mellitus (diagnosed according to the ADA 2014 criteria) to OPDs and admitted in wards and who fulfilled the inclusion criteria were included in the study. Patients were subjected to symptom analysis, clinical examination, BP recording in all 4 limbs, examination of all peripheral pulses, height and weight and BMI calculation. Baseline laboratory investigations, resting 12-lead ECG, and CIMT measurement by ultrasonographic scanning were done for each patient. All these findings were assessed using appropriate statistical methods. RESULTS The study revealed that even in the absence of smoking and alcohol, normotension and normal lipid profile, an increase in the duration of diabetes, altered fasting and postprandial glycaemic status can lead to CIMT>0.9 which is a marker of increased risk for atherosclerosis. CONCLUSION CIMT greater than 0.9 mm is an individual marker of generalised atherosclerosis. Patients with these values are at higher risk for future cardiovascular events and newer or recurrent ischaemic strokes. Measuring CIMT values in all diabetics can predict the risk of developing atherosclerosis related adverse events and better control of diabetes mellitus can aid in achieving regression of CIMT.
Journal of Evidence Based Medicine and Healthcare, 2017
BACKGROUND The Framingham study pointed out that diabetic individuals have dyslipidaemia and hypertension, obesity are more prone to metabolic syndrome and its sequelae namely coronary artery disease (CAD), cerebrovascular disease and vascular atherosclerosis. 1 Carotid intima media thickness (CIMT) is a relatively simple, non-invasive measurement that uses ultrasound to detect the presence of an extent of atherosclerosis. Normal CIMT is 0.9 mm. Aims and Objectives: 1. To evaluate the carotid intima media thickness in 100 patients of type 2 diabetes mellitus with its duration, hypertension, age and sex distribution and also lipid profile abnormalities. 2. To study the correlation of carotid intima media thickness with dyslipidaemia. MATERIALS AND METHODS 100 patients of type 2 diabetes mellitus getting admitted into medical wards of
JPMA. The Journal of the Pakistan Medical Association, 2009
OBJECTIVE To determine the association of Common Carotid Intimal Medial Thickness (CCA-IMT) with risk factors of atherosclerosis in patients with type 2 diabetes mellitus. METHODS This is an observational study carried out in 200 type 2 diabetic patients. Age, gender, duration of diabetes, history of ischaemic heart disease, hypertension and smoking was recorded. Body mass index, glycosylated haemoglobin (HbA1c), total cholesterol, triglyceride and high density (HDL) cholesterol were determined in all the patients. CCA-IMT determination was done by Carotid Doppler Ultrasonography. RESULTS There were 120 (60%) males and 80 females (40%). Ages ranged from 28 to 79, mean 59.5 +/- 9.07 years. IMT on right side ranged from 0.4 mm to 2.4 mm, mean 0.88 mm and on left side mean IMT was 0.93 mm, range 0.5 mm to 2.5 mm. Duration of DM and BMI were correlated with IMT on both the sides (p < .05), statistically inverse correlation was seen with HDL cholesterol (p < .05). No significant co...