Postprandial hypertriglyceridemia and carotid intima–media thickness in north Indian type 2 diabetic subjects (original) (raw)
Related papers
2016
Aim: To investigate the role of postprandial triglyceride levels and its relation with carotid intima media thickness in patients with type 2 diabetes mellitus. Methods: This is a case-control study which comprises 50 patients of age between 40 and 60 years with type 2 diabetes mellitus of more than or equal to 3 years duration. Carotid artery Doppler was done by B-mode ultrasonography using a 7.5MHz transducer. Blood samples were obtained after an overnight fast (12 hours) for total cholesterol, Fasting triglyceride, HDL, LDL, VLDL levels, which are measured by standard laboratory technique. Then patients ate a standard meal that had a total energy of 9 Kcal/Kg with 60-65% of this energy being supplied by carbohydrate, 15-20% by protein and 20% by fat after taking insulin or oral hypoglycemic agent. Blood samples were taken again 4 hours after the meal for postprandial triglyceride level. Results: Patients were divided into three groups. The first group normo-normo (NN) group i.e p...
Diabetes Care, 2000
OBJECTIVE: Serum triglyceride levels are important in the development of atherosclerosis. Although triglyceride levels are generally increased in the postprandial periods, the association between postprandial triglyceride (pTG) levels and atherosclerosis has not been investigated in diabetic patients. To investigate the role of pTG levels in atherosclerosis, we examined the correlation between pTG levels and carotid intimal-medial thickness (IMT). RESEARCH DESIGN AND METHODS: Carotid IMT was measured by ultrasonography in 61 patients with type 2 diabetes. Plasma glucose (PG), insulin, total cholesterol, triglycerides, and HDL cholesterol levels were measured after overnight fasting and 4 h after a meal. RESULTS: Carotid IMT of the patients with fasting hypertriglyceridemia was greater than that of the patients with normal fasting triglyceride (fTG) levels (0.85+/-0.12 vs. 0.76+/-0.14 mm; P = 0.02). The carotid IMT was increased in the patients with pTG levels >2.27 mmol/l. The no...
Journal of Advances in Internal Medicine, 2018
Background and aim: Type 2 diabetes mellitus is associated with the development of premature arteriosclerosis and a higher cardiovascular morbidity and mortality. Diabetic dyslipidaemia is believed to play an important role in the pathogenesis of accelerated atherosclerosis in this condition. B-mode ultrasound enables non-invasive, direct visualization of the arterial wall. The aim of this study was to correlate intima media thickness of the carotid artery (CIMT) quantification as a reliable marker of atherosclerotic burden in diabetes patients.Method: It was a Cross Sectional Study done on 50 patients in the age group of 30-70 years with type II Diabetes Mellitus of more than 5 years duration without hypertension. Carotid Intima Media Thickness (CIMT) was measured using an echotomographic system with a 7.5-MHz linear transducer probe. With the carotid bulb and the longitudinal projection of the common carotid artery 2cmx from carotid bulb, the site of the greatest thickness includi...
Scholars journal of applied medical sciences, 2020
Original Research Article Background: Type-2 Diabetes Mellitus (T2DM) with cardiometabolic risk factors poses the high risk of atherosclerosis. The Intima-Media Thickness (IMT) of carotid artery is reliable indicator of cardiovascular diseases. Aims and objectives: To study the Correlation of Serum Triglyceride level with Carotid Intima-Media Thickness (CIMT) in Type-2 Diabetes Mellitus patients. Materials and Methods: Presentretrospective study was performed on 250 T2DM patients at Department of Medicine, Gandhi Medical College and associated Hamidia Hospital from January 2018 to March 2019. T2DM patients having age 25-65 were enrolled. CIMT was measured with ultrasonography and its correlation was checked with triglyceride serum level. Results: Out of 250, 152 were male and 98 were females. Mean age of cohorts was 53.03 years. out of 250 subjects only 79 has normal fasting triglyceride (FTG) and post prandial triglyceride (PPTG) (mean CIMT was 0.95±0.27), 88 subjects has abnormal PPTG and normal FTG with (mean CIMT 1.63±0.40 mm) and 83 subjects had abnormal FTG and PPTG i.e. ≥150 mg/dl and significantly high CIMT as 1.96±0.61 mm. Conclusion: FTG and PPTG levels are significantly correlated with the carotid intima media thickness. PPTG is indecently and strongly associated with CIMT.
https://www.ijrrjournal.com/IJRR\_Vol.7\_Issue.8\_Aug2020/Abstract\_IJRR0041.html, 2020
Objectives: Study Of Correlation Of Postprandial Lipid Profile With Carotid Intima Media Thickness In Type-II Diabetes Mellitus. Material and Methods: 30 type-2 diabetic patients and 30 healthy non diabetic control subjects will be taken from indoor wards of medicine department. American Diabetes Association Guidelines will be followed to diagnose diabetes episode of cerebrovascular diseases or intracranial space-occupying lesions were excluded. The collected data were analyzed using appropriate statistical test between the variables. Results: The mean Carotid Intima Media Thickness (CIMT) value were found to be raised in diabetic(1.00+-.489) as compared to healthy subjects(.43+-.02) signifying that Type-2 DM is associated with raised CIMT values. Raised CIMT(>0.8mm) was found in 14(46.7%) in diabetic patients as compared to 3(10%) in healthy. Conclusion: Carotid Intima Medial Thickness which is a marker of atherosclerosis and predictor of unfavourable cerebrovascular events which are important cause of morbidity and mortality, is raised in Type-2 DM patients especially those having abnormal fasting and postprandial dyslipidemia, .
1997
The aim of this study was 1) to compare intimal-medial thickness (IMT) of the carotid artery in nondiabetic and NIDDM patients and 2) to evaluate the association of this early marker of atherosclerosis with several cardiovascular risk factors, including plasma insulin and insulin resistance. RESEARCH DESIGN A N D METHODS-A total of 58 nondiabetic and 56 NIDDM patients, randomly selected among those attending the outpatient Diabetes Clinic or the Clinic for Internal Medicine were examined. BM1, waist-to-hip ratio (WHR), blood pressure, glycohemoglobin (HbA lc), and fasting concentrations of plasma glucose, serum lipids (total and HDL cholesterol, triglycerides), and serum insulin were measured. Insulin resistance was assessed by computing glucose disappearance rate from plasma after intravenous insulin injection (K Ut). IMT of the carotid artery was measured by ultrasonography. RESULTS-IMT was significantly higher in diabetic patients, and the difference remained highly significant after adjusting for sex, age, BMI, WHR, presence of hypertension and dyslipidemia, and smoking status (1.39 vs. 1.24 mm, common SD 0.12, P < 0.001). Univariate regression analyses showed that IMT was negatively correlated with K itt in either nondiabetic (r =-0.348, P < 0.01) or diabetic patients (r =-0.492, P < 0.001). However, multiple regression analyses showed that IMT was independently associated with age and WHR in nondiabetic subjects, whereas in diabetic patients, IMT was independently predicted by K itt and hypertension. These two variables explained-62% and ~35% of the variability of IMT in nondiabetic and diabetic patients, respectively. Plasma insulin was not independently associated with IMT in either groups. CONCLUSIONS-These results indicate that I) diabetes is characterized by a greater thickness of the carotid artery independently of other established risk factor of atherosclerosis, 2) early atherosclerosis is independently associated with insulin resistance in diabetic but not in nondiabetic patients, 3) central adiposity is an independent predictor of IMT in nondiabetic individuals. A bout 15 years ago epidemiological prospective studies (Paris Prospective Study, Busselton Study, and Helsinki Policemen Study) reported that hyperinsulinemia can predict coronary heart disease, independently of the presence of diabetes, dyslipidemia, and hypertension (1-3). Despite several inconsistencies within and between these studies, especially in extended follow-up examinations (4-7), From the Division of Metabolic Diseases (E.
Diabetes/Metabolism Research and Reviews, 2001
Objective Atherosclerosis is associated with insulin resistance (IR) and dyslipidaemia. Impaired glucose tolerance (IGT) is characterised by IR and is associated with a higher risk of atherosclerosis. The objective of the present study was to test whether early atherosclerosis indicated by intimal medial thickness (IMT) of common carotid artery (CCA) and internal carotid artery (ICA) is higher in IGT than in normoglycaemic subjects (NGT) and to look for an association of IMT with IR and dyslipidaemia.
Circulation, 2004
Background-Postprandial hyperglycemia may be a risk factor for cardiovascular disease. We compared the effects of two insulin secretagogues, repaglinide and glyburide, known to have different efficacy on postprandial hyperglycemia, on carotid intima-media thickness (CIMT) and markers of systemic vascular inflammation in type 2 diabetic patients. Methods and Results-We performed a randomized, single-blind trial on 175 drug-naive patients with type 2 diabetes mellitus (93 men and 82 women), 35 to 70 years of age, selected from a population of 401 patients who participated in an epidemiological analysis assessing the relation of postprandial hyperglycemia to surrogate measures of atherosclerosis. Eighty-eight patients were randomly assigned to receive repaglinide and 87 patients to glyburide, with a titration period of 6 to 8 weeks for optimization of drug dosage and a subsequent 12-month treatment period. The effects of repaglinide (1.5 to 12 mg/d) and glyburide (5 to 20 mg/d) on CIMT were compared by using blinded, serial assessments of the far wall. After 12 months, postprandial glucose peak was 148Ϯ28 mg/dL in the repaglinide group and 180Ϯ32 mg/dL in the glyburide group (PϽ0.01). HbA 1c showed a similar decrease in both groups (Ϫ0.9%). CIMT regression, defined as a decrease of Ͼ0.020 mm, was observed in 52% of diabetics receiving repaglinide and in 18% of those receiving glyburide (PϽ0.01). Interleukin-6 (Pϭ0.04) and C-reactive protein (Pϭ0.02) decreased more in the repaglinide group than in the glyburide group. The reduction in CIMT was associated with changes in postprandial but not fasting hyperglycemia. Conclusions-Reduction of postprandial hyperglycemia in type 2 diabetic patients is associated with CIMT regression. (Circulation. 2004;110:214-219.)