Optimization of Magnetic Cobalt Ferrite Nanoparticles for Magnetic Heating Applications in Biomedical Technology (original) (raw)
Related papers
Materials Today: Proceedings, 2019
The magnetic cobalt ferrite nanoparticles (CoFe 2 O 4) were synthesized by sol-gel combustion technique and encapsulated with polyethylene glycol (PEG). The phase formation and crystalline nature were confirmed by X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). The microstructure and elemental composition were characterized using Scanning Electron Microscopy (SEM). Magnetic characteristics of the synthesized sample were studied at room temperature using Vibrating Sample Magnetometer (VSM) and its low coercivity value indicates that these nanoparticles are near the superparamagnetic limit. Hyperthermic behavior and cell biocompatibility characteristics with human leucocyte culture were analyzed and results signify that synthesized cobalt ferrite (CoFe 2 O 4) nanoparticles encapsulated with Polyethylene glycol (PEG) are one of the potential candidates for hyperthermia, targeted drug delivery and various other biomedical applications.
Molecules
Magnetic nanoparticles such as cobalt ferrite are investigated under clinical hyperthermia conditions for the treatment of cancer. Cobalt ferrite nanoparticles (CFNPs) synthesized by the thermal decomposition method, using nonionic surfactant Triton-X100, possess hydrophilic polyethylene oxide chains acting as reducing agents for the cobalt and iron precursors. The monodispersed nanoparticles were of 10 nm size, as confirmed by high-resolution transmission electron microscopy (HR-TEM). The X-ray diffraction patterns of CFNPs prove the existence of cubic spinel cobalt ferrites. Cs-corrected scanning transmission electron microscopy–high-angle annular dark-field imaging (STEM–HAADF) of CFNPs confirmed their multi-twinned crystallinity due to the presence of atomic columns and defects in the nanostructure. Magnetic measurements proved that the CFNPs possess reduced remnant magnetization (MR/MS) (0.86), which justifies cubic anisotropy in the system. Microwave-based hyperthermia studies...
Magnetic Hyperthermia Properties of Electrosynthesized Cobalt Ferrite Nanoparticles
The Journal of Physical Chemistry C, 2013
Using the electrochemical route, cobalt ferrite nanoparticles (NPs) with two different sizes were synthesized and stabilized in water by coating with citric acid. The specific absorption rate (SAR) values of aqueous suspensions of magnetic nanoparticles with crystal sizes of 13 and 28 nm were investigated in the frequency range 32−101 kHz and up to 51 mT. SAR values were higher for the larger NPs and reached 133 W/g. Numerical simulations are used for a quantitative analysis of hyperthermia experiments and seem to indicate that the larger NPs are multidomain. Cytotoxicity analysis was also performed in HeLa tumor cells; a null cytotoxicity of these nanoparticles in cell tissues were obtained.
Applications of cobalt ferrite nanoparticles in biomedical nanotechnology
Nanomedicine (London, England), 2018
Magnetic nanoparticles (MNPs) are very attractive especially for biomedical applications, among which, iron oxide nanoparticles have received substantial attention in the past decade due to the elemental composition that makes them biocompatible and degradable. However recently, other magnetic nanomaterials such as spinel ferrites that can provide improved magnetic properties such as coercivity and anisotropy without compromising on inherent advantages of iron oxide nanoparticles are being researched for better applicability of MNPs. Among various spinel ferrites, cobalt ferrite (CoFeO) nanoparticles (NPs) are one of the most explored MNPs. Therefore, the intention of this article is to provide a comprehensive review of CoFeO NPs and their inherent properties that make them exceptional candidates, different synthesis methods that influence their properties, and applications of CoFeO NPs and their relevant applications that have been considered in biotechnology and bioengineering.
IEEE Transactions on Magnetics, 2014
The heating processes in ferrofluids in ac magnetic field depend on chemical composition, dimension, shape, magnetic properties of the nonoparticles, and rheological characteristics of the dispersing medium. By controlling these parameters, a maximum energy can be transferred to the medium. This paper was focused on determining the specific absorption rate (SAR) of a series of nanoparticles (NPs), with ferromagnetic properties at room temperature, dispersed in water to prove their possible use in medical applications. Co x Fe 3−x O 4 (with x = 0.2-1 in steps of 0.2) magnetic fluids were synthesized by the coprecipitation method and subjected to an ac magnetic field with different amplitudes and distinct frequencies. X-ray difractometry and transmission electron microscopy were used to characterize the phase and microstructure of NPs. Vibrating sample magnetometer measurements denoted a ferrimagnetic behavior of the particles at room temperature and expected superparamegnetic behavior for ferrofluids. The values of SAR obtained using a calorimetric method, at fixed frequency, increased with strength of applied field and Co content being higher at low frequencies. The results are explained in terms of relaxation times, and the experimental data were compared with theoretical predictions.
Rare earth metals' influence on the heat generating capability of cobalt ferrite nanoparticles
The aim of this study is to synthesize and assess the potential applications of rare earth doped cobalt ferrite nanoparticles in cancer treatment through hyperthermia. The synthesis of CoFe 2 À x RE x O 4 (where RE ¼Yb, Dy, Gd and x¼0.01–0.3) through the co-precipitation method is presented. The composition and properties of the nanoparticles where investigated and evaluated in correlation with their heat generating capability. The XRD and EDX analysis indicated phase separation for high rare earth content with the appearance of Gd 2 O 3 and Dy 2 O 3 secondary phases, which leads to unwanted changes in the nanoparticles' magnetic properties and consequently of the specific absorption rate. All the nanoparticles present functional group belonging to the surfactant as determined by FT-IR and Raman. Magnetic and specific adsorption rate measurement suggest increases in saturation magnetization and SAR value in doped ferrites, compared to CoFe 2 O 4 with as much as 26% and 15% for Dy doped and Gd doped samples respectively.
Langmuir, 2007
Monodisperse and stable cobalt ferrite (CoFe2O4) nanoparticles (5.4 nm) have been produced, coated with monoand difunctional phosphonic and hydroxamic acids, and fully characterized (using thermogravimetric analysis (TGA), dynamic light scattering (DLS), IR spectroscopy, transmission electron microscopy (TEM), and superconducting quantum interference device (SQUID) measurements). Cobalt leakage of the coated nanoparticles has been also studied. Magnetic measurements show the possible applications in hyperthermia at low frequencies, and for this reason, water-soluble coated CoFe2O4 can be seen as a first step toward the obtainment of novel systems for biomagnetic applications.
In this study, superparamagnetic cobalt ferrite nanoparticles (SCFNs) were synthesized by co-precipitation in one-step. The synthesis parameters; reaction time and stirring rate, were varied separately while the other parameters were fixed constant to investigate the effect of the parameters on the properties of SCFNs. X-ray diffraction analysis and Fourier transform infrared spectroscopy confirmed that synthesized samples are cobalt ferrite. The magnetization consistently increased with the particle size as the reaction time increased and the stirring rate decreased. While the reaction time was effective on the size of the cobalt ferrite nanoparticles, the stirring rate was also found to have influence on the particle size and thus the magnetization of the nano-particles. The critical size of cobalt ferrite nanoparticles for superparamagnetic limit with zero coercivity and remanence was found to be around 7 nm and its maximum magnetization value was 41.0 emu/g. When the size of the SCFNs went over 7 nm, the magnetization increased with a small coercivity of 2-5 Oe, which may offer a potential usage in magnetic hyperthermia applications. It was seen that structural properties, especially the particle sizes and corresponding magnetic properties of SCFNs were considerably affected by the parameters of stirring rate and especially reaction time. Therefore, it is seen that SCFNs with desirable properties can be tailored by changing the synthesis parameters and therefore may have the potential to use in biomedical applications .
2013
Combination of magnetic and biocompatible materials to form core-shell nanomaterials has been widely used in medical fields. These core-shell magnetic biomaterials have a great potential for magnetic fluid hyperthermia (MFH) treatment to remedy cancer. The aims of this study were to investigate the production of core-shell cobalt ferrite/polycaprolactone (CoFe2O4/PCL) nanomaterials with different ratios of cobalt ferrite to caprolactone, to study the effects of using polymer in reducing the agglomerations between particles and to determine the structure, morphology, thermal and magnetic properties of these core-shell nanomaterials. The core-shell nanomaterials were produced by in situ polymerization method. The formation of the CoFe2O4/PCL was investigated by means of Fourier transform infrared spectroscopy (FTIR), x-ray diffractometer (XRD) and transmission electron microscopy (TEM). Its thermal properties were determined by using thermogravimetric analyzer (TGA). The vibrating sam...