Synthesis, Characterization and Magnetic Hyperthermia of Monodispersed Cobalt Ferrite Nanoparticles for Cancer Therapeutics (original) (raw)
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Magnetic Hyperthermia Properties of Electrosynthesized Cobalt Ferrite Nanoparticles
The Journal of Physical Chemistry C, 2013
Using the electrochemical route, cobalt ferrite nanoparticles (NPs) with two different sizes were synthesized and stabilized in water by coating with citric acid. The specific absorption rate (SAR) values of aqueous suspensions of magnetic nanoparticles with crystal sizes of 13 and 28 nm were investigated in the frequency range 32−101 kHz and up to 51 mT. SAR values were higher for the larger NPs and reached 133 W/g. Numerical simulations are used for a quantitative analysis of hyperthermia experiments and seem to indicate that the larger NPs are multidomain. Cytotoxicity analysis was also performed in HeLa tumor cells; a null cytotoxicity of these nanoparticles in cell tissues were obtained.
Advanced Materials, 2020
of an alternating magnetic field (AMF). Most of the studies from the last two decades investigating in vivo oncothermia comprise biocompatible and biodegradable iron oxide-based nanoplatforms. Currently, the only clinically approved magnetic hyperthermia (HT) therapy employs spherical aminosilane coated iron oxide nanoparticles (IONPs, namely, NanoTherm MagForce Nanotechnologies) to treat glioblastoma multiforme in patients and currently in clinical trial for prostate cancer. [1] The major drawback of this system is that it requires a very high concentration of IONPs to achieve the temperature needed to kill cancer cells (43-45 °C). This is mainly due to their low specific absorption rate (SAR) value, which is a direct measure of the heating capacity of the MNPs under AMF. Cubic-shaped IONPs (IONCs) represent by far the benchmark product available with SAR values higher than spherical IONPs specifically due to their particular cubic shape and anisotropy. [2-4] Furthermore, to improve the
Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
Nanomaterials, 2021
Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of 12 nm cobalt ferrite MNPs, functionalized with citrate ions, in different dosages on mice and rats of both sexes was investigated for 30 days after intraperitoneal injection. The animals’ weight, behavior, and blood cells changes, as well as blood biochemical parameters are correlated to histological examination of organs revealing that cobalt ferrite MNPs do not have toxic effects at concentrations close to those used previously for efficient MHT. Moreover, these MNPs demonstrated high specific loss power (SLP) of about 400 W g−1. Importantly the MNPs retained their magnetic properties inside tumor tissue after intratumoral administration for several MHT cycles within thre...
Materials Today: Proceedings, 2019
The magnetic cobalt ferrite nanoparticles (CoFe 2 O 4) were synthesized by sol-gel combustion technique and encapsulated with polyethylene glycol (PEG). The phase formation and crystalline nature were confirmed by X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). The microstructure and elemental composition were characterized using Scanning Electron Microscopy (SEM). Magnetic characteristics of the synthesized sample were studied at room temperature using Vibrating Sample Magnetometer (VSM) and its low coercivity value indicates that these nanoparticles are near the superparamagnetic limit. Hyperthermic behavior and cell biocompatibility characteristics with human leucocyte culture were analyzed and results signify that synthesized cobalt ferrite (CoFe 2 O 4) nanoparticles encapsulated with Polyethylene glycol (PEG) are one of the potential candidates for hyperthermia, targeted drug delivery and various other biomedical applications.
Journal of Magnetism and Magnetic Materials, 2016
In this study, we report a novel synthesis method, characterization and application of a new class of ferromagnetic cubic cobalt ferrite magnetic nanoparticles (MNPs) for hyperthermia therapy and temperature triggered drug release. The MNPs are characterized by XRD, TEM, FESEM, AC magnetic hysteresis and VSM. These MNPs were coated with folic acid and loaded with an anticancer drug. The drug release studies were done at two different temperatures (37°C and 44°C) with progress of time. It was found that higher release of drug took place at elevated temperature (44°C). We have developed a temperature sensitive drug delivery system which releases the heat sensitive drug selectively as the particles are heated up under AC magnetic field and controlled release is possible by changing the external AC magnetic field.
Nanomaterials
Using magnetic nanoparticles for extracorporeal magnetic heating applications in bio-medical technology allows higher external field amplitudes and thereby the utilization of particles with higher coercivities (HC). In this study, we report the synthesis and characterization of high coercivity cobalt ferrite nanoparticles following a wet co-precipitation method. Particles are characterized with magnetometry, X-ray diffraction, Mössbauer spectroscopy, transmission electron microscopy (TEM) and calorimetric measurements for the determination of their specific absorption rate (SAR). In the first series, CoxFe3−xO4 particles were synthesized with x = 1 and a structured variation of synthesis conditions, including those of the used atmosphere (O2 or N2). In the second series, particles with x = 0 to 1 were synthesized to study the influence of the cobalt fraction on the resulting magnetic and structural properties. Crystallite sizes of the resulting particles ranged between 10 and 18 nm,...
Evaluation of iron-cobalt/ferrite core-shell nanoparticles for cancer thermotherapy
Journal of Applied Physics, 2008
Magnetic nanoparticles ͑MNPs͒ offer promise for local hyperthermia or thermoablative cancer therapy. Magnetic hyperthermia uses MNPs to heat cancerous regions in an rf field. Metallic MNPs have larger magnetic moments than iron oxides, allowing similar heating at lower concentrations. By tuning the magnetic anisotropy in alloys, the heating rate at a particular particle size can be optimized. Fe-Co core-shell MNPs have protective CoFe 2 O 4 shell which prevents oxidation. The oxide coating also aids in functionalization and improves biocompatibility of the MNPs. We predict the specific loss power ͑SLP͒ for FeCo ͑SLP ϳ450 W / g͒ at biocompatible fields to be significantly larger in comparision to oxide materials. The anisotropy of Fe-Co MNPs may be tuned by composition and/or shape variation to achieve the maximum SLP at a desired particle size.
2013
Combination of magnetic and biocompatible materials to form core-shell nanomaterials has been widely used in medical fields. These core-shell magnetic biomaterials have a great potential for magnetic fluid hyperthermia (MFH) treatment to remedy cancer. The aims of this study were to investigate the production of core-shell cobalt ferrite/polycaprolactone (CoFe2O4/PCL) nanomaterials with different ratios of cobalt ferrite to caprolactone, to study the effects of using polymer in reducing the agglomerations between particles and to determine the structure, morphology, thermal and magnetic properties of these core-shell nanomaterials. The core-shell nanomaterials were produced by in situ polymerization method. The formation of the CoFe2O4/PCL was investigated by means of Fourier transform infrared spectroscopy (FTIR), x-ray diffractometer (XRD) and transmission electron microscopy (TEM). Its thermal properties were determined by using thermogravimetric analyzer (TGA). The vibrating sam...
International Journal of Molecular Sciences
In this paper, we present a study by computer simulation on superparamagnetic hyperthermia with CoFe2O4 ferrimagnetic nanoparticles coated with biocompatible gamma-cyclodextrins (γ-CDs) to be used in alternative cancer therapy with increased efficacy and non-toxicity. The specific loss power that leads to the heating of nanoparticles in superparamagnetic hyperthermia using CoFe2O4–γ-CDs was analyzed in detail depending on the size of the nanoparticles, the thickness of the γ-CDs layer on the nanoparticle surface, the amplitude and frequency of the alternating magnetic field, and the packing fraction of nanoparticles, in order to find the proper conditions in which the specific loss power is maximal. We found that the maximum specific loss power was determined by the Brown magnetic relaxation processes, and the maximum power obtained was significantly higher than that which would be obtained by the Néel relaxation processes under the same conditions. Moreover, increasing the amplitud...
Chemphyschem : a European journal of chemical physics and physical chemistry, 2018
This work reports the application possibilities of cobalt ferrite (CoFe2O4) magnetic nanoparticles (CFMNPs) for stimuli responsive drug delivery by magnetic field induced hyperthermia technique. The CFMNPs were characterized by XRD (Rietveld analysis), FESEM, TEM, SAED, FTIR, TG-DTA, VSM and SQUID. Particles were functionalized with folic acid (FA) by EDC-NHS coupling method and loaded with anticancer drug (DOX). The drug release was studied as a function of time at two different temperatures (37 and 44 oC) under pH ~5.5 and 7. It was observed that the drug release rate is higher at elevated temperature (44 oC) and acidic pH~5.5 as compared to our normal body temperature and pH ~7 using the CFMNPs. This way, we have developed a pH and temperature sensitive drug delivery system which can release the anticancer drug selectively by applying ac magnetic field as under ac field particles are heated up. We have calculated the amount of heat generation by the particles around 1.67 oC per s...