Mammalian Sprouty Proteins Inhibit Cell Growth and Differentiation by Preventing Ras Activation (original) (raw)
Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis
David Warburton
Mechanisms of Development, 2001
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Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila
Mark Krasnow
1999
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Inhibition of Angiogenesis by a Mouse Sprouty Protein
Mark Krasnow
Journal of Biological Chemistry, 2000
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Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling
Graeme Guy
The EMBO Journal, 2002
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Sprouty2 Inhibits the Ras/MAP Kinase Pathway by Inhibiting the Activation of Raf
Graeme Guy
Journal of Biological Chemistry, 2002
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Tyrosine Phosphorylation of Sprouty Proteins Regulates Their Ability to Inhibit Growth Factor Signaling: A Dual Feedback Loop
Hamid Band
Molecular Biology of the Cell, 2004
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Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis
David Warburton
Current Biology, 1999
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Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain
Graeme Guy
The Journal of biological chemistry, 2000
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Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling
John Heath
The Journal of Cell Biology, 2009
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FGF Signal Interpretation Is Directed by Sprouty and Spred Proteins during Mesoderm Formation
J. Sivak
Developmental Cell, 2005
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Distinct requirements for the Sprouty domain for functional activity of Spred proteins
Peter Lock
Biochemical Journal, 2005
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Phosphorylation of Carboxyl-terminal Tyrosines Modulates the Specificity of Sprouty-2 Inhibition of Different Signaling Pathways
Dina Ron
Journal of Biological Chemistry, 2005
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branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching
Mark Krasnow
Cell, 1996
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Sprouty proteins: modified modulators, matchmakers or missing links?
Graeme Guy
Journal of Endocrinology, 2009
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Functional analysis of the human Sprouty2 gene promoter
David Warburton
Gene, 2003
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Oxygen Regulation of Airway Branching in Drosophila Is Mediated by Branchless FGF
Mark Krasnow
Cell, 1999
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A Src Homology 3-binding Sequence on the C Terminus of Sprouty2 Is Necessary for Inhibition of the Ras/ERK Pathway Downstream of Fibroblast Growth Factor Receptor Stimulation
tt saw
Journal of Biological Chemistry, 2006
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Sprouty2 mediated tuning of signalling is essential for somite myogenesis
Muhammad Abu-Elmagd, Katarzyna Goljanek-Whysall
BMC medical genomics, 2015
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Mammalian Sprouty-1 and -2 Are Membrane-Anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells
amelia compagni
Journal of Cell Biology, 2001
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Tracheal occlusion increases the rate of epithelial branching of embryonic mouse lung via the FGF10-FGFR2b-Sprouty2 pathway
David Warburton
Mechanisms of Development, 2008
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FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity
John Heath
Journal of Cell Science, 2004
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Temporal effects of Sprouty on lung morphogenesis
Isamu Hokuto
Developmental Biology, 2003
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Sprouty-2 Overexpression in C2C12 Cells Confers Myogenic Differentiation Properties in the Presence of FGF2
natalia martinez
Molecular Biology of The Cell, 2005
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Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2
Dmitry Kovalenko
Journal of Cellular Biochemistry, 2007
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Intermolecular Interactions of Sprouty Proteins and Their Implications in Development and Disease
Francis Edwin
Molecular Pharmacology, 2009
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Reiterative use of signalling pathways controls multiple cellular events during Drosophila posterior spiracle organogenesis
Yacine Graba
Developmental Biology, 2010
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FGF Signaling Pathway in the Developing Chick Lung: Expression and Inhibition Studies
Paulo O Mota
PLoS ONE, 2011
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FGF 10 and Sprouty 2 modulate trophoblast invasion and branching morphogenesis
D. Hochner-celnikier
Molecular Human Reproduction, 2007
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Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system
Mark Krasnow
Genes & …, 1996
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mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins
David Warburton
American journal of physiology. Lung cellular and molecular physiology, 2002
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stumps, a Drosophila gene required for fibroblast growth factor (FGF)-directed migrations of tracheal and mesodermal cells
Farhad Imam
Genetics, 1999
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Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis
Rudolf Jaenisch
Genes & Development, 2007
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