Mammalian Sprouty Proteins Inhibit Cell Growth and Differentiation by Preventing Ras Activation (original) (raw)

Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis

David Warburton

Mechanisms of Development, 2001

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Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila

Mark Krasnow

1999

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Inhibition of Angiogenesis by a Mouse Sprouty Protein

Mark Krasnow

Journal of Biological Chemistry, 2000

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Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

Graeme Guy

The EMBO Journal, 2002

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Sprouty2 Inhibits the Ras/MAP Kinase Pathway by Inhibiting the Activation of Raf

Graeme Guy

Journal of Biological Chemistry, 2002

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Tyrosine Phosphorylation of Sprouty Proteins Regulates Their Ability to Inhibit Growth Factor Signaling: A Dual Feedback Loop

Hamid Band

Molecular Biology of the Cell, 2004

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Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis

David Warburton

Current Biology, 1999

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Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain

Graeme Guy

The Journal of biological chemistry, 2000

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Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling

John Heath

The Journal of Cell Biology, 2009

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FGF Signal Interpretation Is Directed by Sprouty and Spred Proteins during Mesoderm Formation

J. Sivak

Developmental Cell, 2005

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Distinct requirements for the Sprouty domain for functional activity of Spred proteins

Peter Lock

Biochemical Journal, 2005

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Phosphorylation of Carboxyl-terminal Tyrosines Modulates the Specificity of Sprouty-2 Inhibition of Different Signaling Pathways

Dina Ron

Journal of Biological Chemistry, 2005

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branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching

Mark Krasnow

Cell, 1996

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Sprouty proteins: modified modulators, matchmakers or missing links?

Graeme Guy

Journal of Endocrinology, 2009

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Functional analysis of the human Sprouty2 gene promoter

David Warburton

Gene, 2003

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Oxygen Regulation of Airway Branching in Drosophila Is Mediated by Branchless FGF

Mark Krasnow

Cell, 1999

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A Src Homology 3-binding Sequence on the C Terminus of Sprouty2 Is Necessary for Inhibition of the Ras/ERK Pathway Downstream of Fibroblast Growth Factor Receptor Stimulation

tt saw

Journal of Biological Chemistry, 2006

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Sprouty2 mediated tuning of signalling is essential for somite myogenesis

Muhammad Abu-Elmagd, Katarzyna Goljanek-Whysall

BMC medical genomics, 2015

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Mammalian Sprouty-1 and -2 Are Membrane-Anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells

amelia compagni

Journal of Cell Biology, 2001

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Tracheal occlusion increases the rate of epithelial branching of embryonic mouse lung via the FGF10-FGFR2b-Sprouty2 pathway

David Warburton

Mechanisms of Development, 2008

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FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity

John Heath

Journal of Cell Science, 2004

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Temporal effects of Sprouty on lung morphogenesis

Isamu Hokuto

Developmental Biology, 2003

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Sprouty-2 Overexpression in C2C12 Cells Confers Myogenic Differentiation Properties in the Presence of FGF2

natalia martinez

Molecular Biology of The Cell, 2005

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Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2

Dmitry Kovalenko

Journal of Cellular Biochemistry, 2007

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Intermolecular Interactions of Sprouty Proteins and Their Implications in Development and Disease

Francis Edwin

Molecular Pharmacology, 2009

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Reiterative use of signalling pathways controls multiple cellular events during Drosophila posterior spiracle organogenesis

Yacine Graba

Developmental Biology, 2010

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FGF Signaling Pathway in the Developing Chick Lung: Expression and Inhibition Studies

Paulo O Mota

PLoS ONE, 2011

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FGF 10 and Sprouty 2 modulate trophoblast invasion and branching morphogenesis

D. Hochner-celnikier

Molecular Human Reproduction, 2007

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Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system

Mark Krasnow

Genes & …, 1996

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mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins

David Warburton

American journal of physiology. Lung cellular and molecular physiology, 2002

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stumps, a Drosophila gene required for fibroblast growth factor (FGF)-directed migrations of tracheal and mesodermal cells

Farhad Imam

Genetics, 1999

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Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

Rudolf Jaenisch

Genes & Development, 2007

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