The probiotic in complex treatment of children with asthma (original) (raw)
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CHILD`S HEALTH, 2020
На допомогу педіатру / To Help the Pediatrician Opportunities of prevention of asthma exacerbation induced by respiratory infection in children using bacterial lysates Abstract. The infectious factor is known to play an important role not only as a trigger for asthma exacerbation, but also an essential factor for the formation of the disease. Children with asthma are 6.2 times more likely to have acute respiratory diseases than healthy children. This is due to altered barrier function of the respiratory epithelium and immune antiviral responses. Viruses dominate in the etiologi-cal structure of infectious-dependent exacerbations of asthma. The preclinical and clinical studies have shown the effectiveness of an immunomodulatory strategy for the prevention of recurrent respiratory infections in children with asthma using bacterial mechanical lysates.
Position of anticholinergic drugs in the treatment of childhood asthma
Srpski arhiv za celokupno lekarstvo, 2010
1 Педијатријска клиника, Клинички центар "Крагујевац", Крагујевац, Србија; 2 Универзитетска дечја клиника, Београд, Србија UVOD Bron hi jal nu ast mu od li ku ju pre o se tqi vost bron ha i za pa qe we. Pre o se tqi vost bron ha je sklo nost di saj nih pu te va da na či ni oce sre di ne re a gu ju su ža va wem ve ćeg ste pe na; to je po ja ča na re ak tiv nost di saj nih pu te va, od no sno la ko ća ko jom se su ža va ju di saj ni pu te vi na raz li či te ne a ler gij ske i aler gij ske sti mu lu se. U ra do vi ma Gro sa (Gross) [1] i dru gih pul mo lo ga i fi zi o lo ga sve ta naj če šće pri hva će na hi po te za je da auto nom ni ner vni si stem uče stvu je u kon tro li to nu sa glat ke mu sku la tu re di saj nih pu te va (Sli ka 1). Bron ho kon strik ci ja je po sle di ca de lo va wa oslo bo đe nih me di ja to ra iz ma sto ci ta na glat ke mi šić ne će li je. Me di ja to ri ma sto ci ta ko ji do vo de do bron ho kon strik ci je su hi sta min, pro sta glan din D2, le u ko trien C4 i ki ni ni (Sli ka 2).
Asthma and allergy, 2018
The efficacy of preventive therapy for bronchial asthma was analyzed among 136 children and influencing factors were determined. The technology of personified phenotype-associated baseline therapy for bronchial asthma in children with different levels of total IgE in blood serum and genotypes with the AT2R1 gene was developed: for the genotype AT2R1 CC and IgE > 400 IU/l an inhaled corticosteroid with a long-acting beta 2-agonist and the leukotriene-receptor antagonist; for the genotype AT2R1 CC and IgE < 400 IU/l-ICS and long-acting beta 2-agonist; for the genotype AT2R1 AC and IgE > 400 IU/l-only leukotriene-receptor antagonist; for the genotype AT2R1 AC and IgE < 400 IU/l-only inhaled corticosteroid. Individual selection of basic therapy regimen, with due to the patient's phenotype and its genotype characteristics, favor to increasing level of asthma control in 3.4 times through the reduction of the day and night symptoms frequency, the need for short-acting bronchodilators and increasing of the expiratory air flow in the lungs by the forced exhalation volume (FEV 1) at 16.5%.
Oral health in children with asthma
Srpski arhiv za celokupno lekarstvo, 2015
Introduction. It has been suggested that asthmatic patients may have a higher risk for oral diseases, both as a result of the medical condition and effects of medications. Objective. The aim of the study was to determine the oral health status of children with asthma and to evaluate the oral health parameters according to the medications and severity of the disease. Methods. The study group consisted of 158 children with asthma and 100 healthy control subjects aged 2-18 years. The diagnosis of dental caries was performed using the Decayed, Missing, and Filled Teeth (DMFT/dmft) criteria. The oral hygiene, periodontal status and gingival health were assessed with the Simplified Oral Hygiene Index (Greene-Vermillion), Community Periodontal Index of Treatment Needs and Gingival Index (L?e-Silness), respectively. Results. Thirty (19%) patients with asthma and 43 (43%) healthy children were caries-free (p<0.001). There were no significant differences between asthmatic and control child...
The role of probiotics in the correction of the gastrointestinal disorders in children
Лечащий врач, 2021
В статье представлен обзор исследований, посвященных изучению эффективности и безопасности пробиотиков в комплексной терапии нарушений желудочно-кишечного тракта у детей различного возраста. Отмечено, что ежедневное применение препаратов, содержащих Lactobacillus reuteri protectis в виде капель, растворенных в грудном молоке или смеси, существенно снижает длительность плача, увеличивает количество и качество дефекаций, снижает количество регургитаций. Кроме того, L. reuteri protectis обладают противовоспалительным, противомикробным и противовирусным действием, участвуют в цитомукопротекции за счет образования специфических биопленок на слизистой кишечника, а также продуцируют гамма-аминомасляную кислоту – основной нейрорегулятор моторной функции кишечника. Эти свойства обуславливают эффективность штамма в лечении и профилактике синдрома раздраженного кишечника, функциональной абдоминальной боли, а также гастрита и язвенной болезни, ассоциированных с Helicobacter pylori. В большинств...
Bukovinian Medical Herald, 2021
Objective. To assess the effectiveness of achieving and maintaining control of bronchial asthma in children during dynamic observation, depending on the characteristics of the onset of the disease. Material and methods. In order to study the peculiarities of the course and controllability of bronchial asthma in children, depending on the alternative onset of the disease, 319 children were comprehensively examined by the "experience-control" method in parallel groups using a simple random sample on the basis of the Regional Children's Clinical Hospital in Chernivtsi. In 257 patients (I clinical group), bronchial asthma developed on the background of chronic obstructive bronchitis, the II clinical group included 43 children in whom BA debuted after suffering community-acquired pneumonia, and the third (III) clinical group was formed by 19 children in whom BA was verified after inpatient treatment for status asthmaticus. Research results. It was shown that the representat...
2017
У навчальному посібнику подані сучасні уявлення про етіологію, патогенез, класифікацію, клініку, діагностику та диференціальну діагностику бронхіальної астми у дітей. Детально обговорюються питання немедикаментозного і медикаментозного лікування бронхіальної астми. В останніх розділах наведені тестові завдання та клінічні задачі для самоконтролю. Посібник рекомендований для студентів старших курсів вищих медичних навчальних закладів ІV рівня акредитації, лікарів-інтернів, лікарів-слухачів курсів підвищення кваліфікації факультетів післядипломної освіти, а також педіатрів, сімейних лікарів, дитячих алергологів, пульмонологів та лікарів усіх спеціальностей, яким у процесі своєї діяльності доводиться стикатися з бронхіальною астмою
Tiotropium: efficacy and safety in pediatric bronchial asthma
Meditsinskiy sovet = Medical Council, 2021
Bronchial asthma is one of the most common chronic lung diseases observed in children. According to the international and Russian guidelines, the long-term objectives of asthma treatment in children and adolescents are to achieve good symptom control, minimize the risk of asthma exacerbations, reduce hospital admissions, decrease the use of short-acting bronchodilators, reduce restrictions in the airflow and side effects, and ensure that normal activity levels are maintained. The asthma treatment is based on the use of inhaled corticosteroids as a backbone therapy and addition of adjunctive therapy if the disease control is poor or worsening. Tiotropium bromide is the first anticholinergic drug that has been approved for children and adults with poorly controlled asthma and is currently used as a treatment option for moderate to severe bronchial asthma. Randomized clinical trials in children and adolescents with persistent bronchial asthma showed high efficacy and safety of tiotropi...