Evaluation of Antiulcer Activity of Aqueous Extract of Albizzia Lebbeck Benth. Leaves in Rats (original) (raw)
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Journal of Applied and Natural Science
Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively. Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing it...
Albizzia lebbeck Benth (Family Mimoseaceae) is used traditionally in Indian System of Medicine for various ailments. Present study aims at the gastroprotective effect ethylacetate and saponin fraction of Albizzia lebbeck bark which were administered orally as pretreatment for ethanol (EtOH), cold-restraint stress (CRS) and pylorus ligation (PL) induced ulcers. Estimation of gastric secretion parameters like volume of gastric juice, acid output, and pH value were estimated in PL induced ulcer model. The results of our study revealed that Albizzia lebbeck bark ethylacetate extract showed dose-dependent ulcer protective effect on peptic ulcers induced by physical and chemical agents in rodents.
In vivo aspirn induced peptic ulcer study of Albizzia lebbeck Benth in rodents
Ethnopharmacological relevance: Albizzia lebbeck Benth is a medicinal plant traditionally used to treat various ailments, including ulcers In order to establish pharmacological properties of the bark of Albizzia lebbeck, studies were performed on antiulcer activity of the plant’s methanolic extract. The Albizzia lebbeck methanolic extract (ALME) was prepared in the doses of 100, 200 mg/kg. Antiulcer activity of ALME was evaluated by aspirin induced gastric ulcer. Acute toxicity was also carried out. ALME, at the dose of 5000 mg/kg, did not cause any signs of toxicity to rats when given orally. Oral administration of ALME exhibited antiulcer activity. Histological studies supported the observed antiulcer activity of ALME. The ALME exhibits antiulcer activity, which could be due to the presence of flavonoids of Albizzia lebbeck in the treatment of ulcers.
Studies on Activity of Various Extracts of Albizia amara against Drug induced Gastric Ulcers
Pharmacognosy Journal, 2011
nitric oxide). [4] The goals of treating peptic ulcer disease are to relieve pain, heal the ulcer and prevent ulcer recurrence. Currently there is no cost-effective treatment that meets all these goals. Hence, efforts are on to find a suitable treatment from natural product sources. Albizia amara (Fabaceae) is a plant used in traditional system of medicine in india. The seeds of Albizia amara used as an astringent, treating piles, diarrhoea, gonorrhoea, leprosy, leucoderma, erysipelas and abscesses. [5] The flowers have been applied to boils, eruptions, swellings, ulcers, also regarded as an emetic, to tackle hair-fall and dandruff on the scalp and as a remedy for coughs and malaria. It is also known as "Kaunthia", a native term originated from Hindi language, indicating an age-old usage of those species by indian indigenous communities. [6] Other popular names are oil cake tree. Leaves were used to tackle hair-fall and dandruff on the scalp. It is used to make hair protective oils. A simple application involves soaking the leaves and flowers in water and using a wet grinder to make a thick paste, and used as a natural shampoo. However there are no reports on the antiulcer activity of the plant hence the present study was designed to verify the claims of the native practioners.
Journal of Traditional and Complementary Medicine, 2016
Albizzia lebbeck Benth. (Mimosaceae) is a medicinal tree used to treat several inflammatory ailments in the Indian traditional Ayurvedic system of medicine. The aim of the present study was to evaluate the possible anti-inflammatory activity of the aqueous (AE) and ethanolic (EE) extracts of the leaves of A. lebbeck to support the ethnopharmacological claims. The study was carried out using Wistar rats (100e150 g). The AE and EE were prepared using the Soxhlet extraction process. The anti-inflammatory activity of the AE and EE of the leaves of A. lebbeck were studied using carrageenan-induced paw edema and cotton pellet-induced granuloma models. The AE and EE of the leaves of A. lebbeck at doses of 50, 100, and 200 mg/kg p.o. (oral administration) showed a dose-dependent and significant (p < 0.05) inhibition of carrageenan-induced hind paw edema with maximum percentage inhibition (PI) values of 22.
Aalgesic Ad Atipyretic Activity of Albizzia Lebbeck
2010
Summary The alcoholic maceration extract from aerial parts of Albizzia lebbeck leaves ( Leguminosae ) was investigated for analgesic activity by tail flick model and anti-pyretic activity by Brewer’s yeastinduced pyrexia in Wistar rats. The extract at 200 mg/kg and 400 mg/kg body weight doses was found to possess significant (p<0.05) and dose dependent analgesic and anti-pyretic activity in animal models. Further, the acute toxicity study with the extract showed no sign of toxicity up to a dose level of 2000-mg/kg. The potential to cause ulcer by extract was comparatively less than that of diclofenac sodium. Thus it could be concluded that Albizzia lebbeck alcoholic extract possess significant analgesic and anti-pyretic activity.
Journal of Pharmacognosy and Phytochemistry, 2016
Introduction:Ulcer serious health issue associated with high risk of mortality and morbidity. This study was carried out to determine protective effects of Aloe vera in indomethacin induced ulcers in albino rats. rnMaterials and Methods:Albino rats were divided into four group five rats per group. Group I: control group, placed on food and water only. Group II: Indomethacin induced gastric ulcer. Group III: Aloe vera pre-treated.Group IV: Omeprazole pre-treated group. Liver enzymes, ulcer index and histological changes on the stomach were studied using standard methods.Results:There was an increased in the serum levels of AST and ALT while ALP levels decreased in gastric ulcer untreated. These enzymes were observed to be normal in Aloe vera pre-treated group and omeprazole pre-treated group. There was also a decreased level of serum bicarbonate and an increased level of serum chloride in the gastric ulcer untreated group when compared to Aloe vera pre-treated group and omeprazole pr...
Toxicity Studies of the Crude Aqueous Root Extract of Albizzia chevalieri Harms in Albino Rats
Nigerian Journal of Basic and Applied Sciences, 2011
Aqueous root extract of Albizzia chevalieri has been reported to possess hypoglycaemic and hypolipidaemic effects. The current work investigated the LD 50 of the crude aqueous root extract of Albizzia chevalieri and the effect of sub-chronic doses of the extract on liver and kidney function parameters of albino rats. The results indicated LD 50 greater than 3000mg/kg body weight in albino rats observed for 72 hours. The result of the sub-chronic toxicity on liver function parameters showed significant (P<0.05) increase in serum total protein and globulin at doses greater than 2000mg//kg, which was reflected on the A:G ratio. Transaminases and alkaline phosphatase activities were also significantly (P<0.05) affected at doses greater than 2000mg/kg. Serum levels of urea were also increased significantly (P<0.05) but creatinine and uric acids were decreased significantly (P<0.05) at doses greater than 2000 mg/kg., Serum electrolytes were however not affected. The extract should therefore be use with care especially at doses greater than 2000 mg/kg.
Toxicity Studies of the Crude Aqueous Root Extract of Albizzia chevalieri Harms in Albino Rats
Nigerian Journal of Basic and Applied Sciences, 2011
Aqueous root extract of Albizzia chevalieri has been reported to possess hypoglycaemic and hypolipidaemic effects. The current work investigated the LD 50 of the crude aqueous root extract of Albizzia chevalieri and the effect of sub-chronic doses of the extract on liver and kidney function parameters of albino rats. The results indicated LD 50 greater than 3000mg/kg body weight in albino rats observed for 72 hours. The result of the sub-chronic toxicity on liver function parameters showed significant (P<0.05) increase in serum total protein and globulin at doses greater than 2000mg//kg, which was reflected on the A:G ratio. Transaminases and alkaline phosphatase activities were also significantly (P<0.05) affected at doses greater than 2000mg/kg. Serum levels of urea were also increased significantly (P<0.05) but creatinine and uric acids were decreased significantly (P<0.05) at doses greater than 2000 mg/kg., Serum electrolytes were however not affected. The extract should therefore be use with care especially at doses greater than 2000 mg/kg.
Phyto-Pharmacological Profile of Albizzia lebbeck
2010
The plant Albizzia lebbeck Benth. [Mimosaceae] is reported to possess anti-asthmatic, anti-inflammatory, antifertility and anti-diarrhoeal properties. Albizzia lebbeck is an important source of chemicals of melacacidin, D-catechin, b-Sitosterol, Albiziahexoside, betulnic acids which are effective as antiseptic, anti-dysenteric, anti-tubercular and used in bronchitis, leprosy, paralysis, helmenth infection etc. Hence in view of immense medicinal importance of the plant this review is therefore an effort to compile all the information reported on its phytochemical and pharmacological activities. This information will be helpful to create interest towards the plant and may be useful in developing new formulations, which are more effective and have more therapeutic value.