Recurrent ovarian steroid cell tumour not otherwise specified: A case report (original) (raw)
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Journal of ovarian research, 2013
Ovarian steroid cell tumors, not otherwise specified (NOS) are rare sex cord-stromal tumors of the ovary with malignant potential. So far only a few cases were reported in English literature through the Pubmed search. Here we report two cases of such tumor, one was benign (first case underwent laparoscopic cystectomy) and the other was malignant (died 10 months later after initial diagnosis), both presented with amenorrhea and clinical signs or symptoms of virilization. In malignant case, we provided evidence (tumor embolus) in addition to the reported five characteristics associated with malignancy. On further evaluation, laboratory investigations revealed hyperandrogenism in the male range, while follicle stimulating hormone (FSH) and luteinising hormone (LH) levels were within normal limits. Various aspects of the presentation, diagnosis, and treatment of these tumors are discussed.
An Early Diagnosis of an Ovarian Steroid Cell Tumor Not Otherwise Specified in a Woman
Case Reports in Obstetrics and Gynecology, 2019
Steroid cell tumor not otherwise specified is a subtype of steroid ovary tumors. These are a rare subgroup of ovarian sex cord-stromal tumors. We present a case of a young woman submitted to laparoscopic cystectomy with ovarian steroid cell tumor as histological finding. This represents the second case where laparoscopic cystectomy is performed in this type of tumor. Up to 36 months after surgery, the woman remains under surveillance, without recurrence of the tumor, and attempts to conceive. This case suggests that steroid cell tumors can be asymptomatic, and gynecologists must think about preserving fertility in women of reproductive age.
Ovarian Steroid Cell Tumor: A Case Report
IOSR Journals , 2019
Introduction: Ovarian steroid cell tumors are a rare subgroup of sex cord stromal tumors of the ovary and comprise less than 0.1% of all ovarian tumors. Case report: A 12 year old patient presented with abdominal pain and found to have right ovarian cyst, right ovarian cystectomy done for the same and histopathology revealed ovarian steroid cell tumor and the same was confirmed by immunohistochemistry with positivity for Vimentin, Calretinin and Inhibin. Conclusion: Ovarian steroid cell tumours, NOS, are rare tumours. Along with clinical correlation, histopathology is the gold standard to confirm the diagnosis in most of the cases. In atypical cases, immunohistochemistry can be helpful for accurate diagnosis. The treatment varies from ovarian cystectomy to total abdominal hysterectomy with bilateral salpingo-oophorectomy depending on histopathological features of malignancy.
Ovarian Steroid Cell Tumor: Report Of Four Cases
Journal of Turkish Society of Obstetric and Gynecology, 2013
Steroid cell tumors are tumors that account for less than 0.1% of all ovarian malignant tumors and cause increase in secretion of androgen or estrogen. Steroid cell tumors usually occur in the post-menopausal period. This article reports four steroid cell tumor cases who underwent surgery for overian mass during post-menopausal period, who were diagnosed with steroid cell tumor after histopathological examination and displayed different clinical manifestations. No signs of increased hormonal activity in two of these cases were observed. On the other hand, the other two cases applied with complaints of menopausal vaginal bleeding, which led to the consideration of increased estrogenic activity in these two cases.
Ovarian Steroid Cell Tumor, Not OtherwiseSpecified (NOS)
International Journal of Gynecological Pathology, 2011
Ovarian steroid cell tumors, not otherwise specified (OSCTs), are extremely rare and present a diagnostic challenge when evaluating an ovarian mass. We present a case of such a tumor in a patient with known Congenital Adrenal Hyperplasia (CAH), secondary to 21-hydroxylase deficiency, who was noncompliant with her medications. The workup, diagnosis, and treatment of this rare condition are described.
Rare Case of Ovarian Steroid Cell Tumor Not Otherwise Specified in a Postmenopausal Woman
Journal of Morphological Sciences, 2022
Ovarian steroid cell tumors, not otherwise specified (NOS), are rare ovarian sex cord-stromal tumors with malignant potential. They represent less than 0.1% of all ovarian neoplasms. Little is known about this tumor, it is rare, and only a small number of case reports are available in the literature. This type of tumor can produce testosterone, leading to hyperandrogenism, virilization and amenorrhea. Postmenopausal occurrences are rare. We present a 60-year-old woman with onset of virilization, worsening alopecia and excessive growth of hair on abdominal and genital parts of the body. She has elevated levels of adrenal androgens. Radiologic studies were consistent with left sided ovarian changes. A diagnostic and therapeutic bilateral salpingo-oophorectomy confirmed steroid cell tumor NOS in both ovaries. Post-operatively, the patient had complete resolution of her symptoms and normalization of testosterone levels.
Steroid cell tumour of ovary: A rare clinicopathologic entity
Indian Journal of Obstetrics and Gynecology Research, 2018
Steroid cell tumors not otherwise specified (SCT-NOS)' are rare sex cord-stromal tumors of the ovary with malignant potential, accounting for less than 0.1% of all ovarian tumors with the highest incidence in premenopausal women. These tumours represent a unique cause of female virilization. We present a case of a 48-year-old post-menopausal lady with bleeding per vagina and a 2-year history of truncal obesity and hirsutism. Past history was unremarkable. Examination revealed feature of obesity, virilization and clitoromegaly. Serum testosterone was 3.62 µg/L& CA-125 was 40.67. CECT gave the evidence of adnexal tumor, but histopathology confirmed SCT-NOS. Total abdominal hysterectomy(TAH) and bilateral salpingoophorectomy(BSO) was performed. Post-operative period was uneventful. This case is being reported for its rarity of occurrence and challenges faced in diagnosis of this case.
Steroid cell tumor : A rare ovarian tumor
Annals of Pathology and Laboratory Medicine
Ovarian steroid cell tumors are sex-cord stromal tumors that arise from lutein cells or leydig cells. These are very rare-accounting for <0.1% of all ovarian tumors.. Some of these tumors may be functional and secrete hormones. Nearly 56-77% of the cases present with hyperandrogenism. Rarely steroid cell tumors may arise in the adrenal cortex from the adrenal rest cells We report a case of a 60-year old lady who presented with gradual onset abdominal distension for two years. She had no other complains and had undergone hysterectomy 20 years back. Her abdomen was over distended due to a large, tense cystic, non-tender mass. Imaging studies revealed a large, mainly cystic abdominopelvic mass; however its origin could not be made out. The left adrenal gland was found to be bulky but morphologically normal. Serum DHEAS levels were normal thus ruling out adrenal pathology. Serum levels of CA 125 and CEA were also normal. Exploratory laparotomy was done. A large thin walled cyst occupied the pelvis and abdomen.. It measured 25x20x16cm and contained 4.2 litre of straw colored fluid. The fluid was drained and the entire cyst wall was excised. Ovaries were not visualized. Frozen section report of the cyst wall was suggestive of a neuroendocrine tumor. Final histopathology report was of benign steroid cell tumor not otherwise specified.
Steroid Cell Tumor of the Ovary: A Rare Case Report
Apollo Medicine, 2008
Sex cord-stromal tumors (SCST) are rare tumors of the ovary that include three main subtypes known as pure stromal tumors, pure sex cord tumors, and mixed sex-cord stromal tumors. This case involves a 25year-old female who presented to the Gynecology outpatient clinic with a two-year history of amenorrhea associated with excessive hair growth since menarche. Ultrasonography revealed a solid left ovarian mass. Histopathology confirmed a diagnosis of SCST not otherwise specified with no cytological atypia. In this case report, we describe the process of managing this patient and a brief literature review on the updates regarding the clinical presentation, molecular changes, and management of SCSTs not otherwise specified.
Steroid cell tumour of the ovary: a case report with review of literature
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Virilising ovarian tumours account for less than 5% of all ovarian tumours. A steroid cell tumour (SCTs) of the ovary comes under the sex cord stromal tumours and accounts for only 0.1% of all ovarian tumours. Almost 75% are functioning tumors with production of androgenic hormones causing virilisation and cushingoid features. They are usually unilateral, benign with only 25-45% malignant cases. Here authors report the incidence of steroid cell tumour in our institution and discuss about a 37-year-old woman with steroid cell tumour, not otherwise specified who presented with oligomenorrhea followed by amenorrhea, secondary infertility and signs of virilisation.