Serum adiponectin and cortisol levels are not affected by studied ADIPOQ gene variants: Tehran lipid and glucose study (original) (raw)
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Association of Adiponectin with Components of Metabolic Syndrome in Western U
2019
Introduction: Obesity is common and unequivocally associated with several serious complications as Metabolic Syndrome (MetS). Despite considering obesity as a defaulter in reducing life expectancy, an exponential weight gain from one generation to the next is not inevitable. According to International Diabetes Federation (IDF), central obesity is a must criterion to define MetS. A number of obesity related peptide hormones have been recognised to play a role in the pathogenesis of MetS. Adiponectin is a recently identified most abundant adipose-tissue derived protein that is potentially antiatherogenic & anti-inflammatory in nature. Out of all adipokines secreted from adipose tissue, only adiponectin founds to be reduced with increasing obesity. Material Method: Adiponectin (ADI) level varies depending on gender, age & ethnic background therefore we aim to circulate and explore the relation of serum adiponectin with escalating components of MetS in study population of Meerut (U.P) India. It is necessary to find accountability of adiponectin in MetS prior to its implementation in clinical practice. The study was conducted on MetS patients attending OPD of Chhatrapati Shivaji Subharti Hospital, Meerut from December 2016-December 2017. Total of 175 subjects (122 with MetS and 53 non-MetS) were included. Their anthropometric parameters, sugar, Lipid & Adiponectin level were measured. Result: On comparison between controls & the subject of MetS, level of serum adiponectin was significantly lower (p<0.05) in the subjects with MetS. Adiponectin is positively correlated with age, diastolic B.P, cholesterol, HDL & LDL while negatively correlated with BMI, systolic B.P, Fasting glucose, TG & VLDL. Serum adiponectin is decreasing with the increasing number of MetS components being insignificantly higher among females than males (p≥0.05).
SERUM ADIPONECTIN LEVEL IN OBESE AND NON OBESE TYPE 2 DIABETES MELLITUS
Back ground: Worldwide diabetes mellitus is no more an epidemic; rather it has turned into a pandemic health hazard. Association of obesity in type 2 diabetes mellitus is an established fact. This association could be partly mediated by altered secretion of adipokines by adipose tissue. Among all adipokines, adiponectin has been considered as an important factor in obesity induced insulin resistance. This new hormone produced exclusively by adipocytes differs from its predecessors in at least one important feature. While all of the other adipose tissue derived hormones related to insulin resistance are increased in obesity, adiponectin production and concentration actually decreases in obese subjects. Objective: the study was taken up to investigate the relationship between adiponectin in obese and non obese type 2 diabetes, and also to find out the correlation between adiponectin and serum lipids in urban south Indian population. Method: The cases chosen for the study group were already diagnosed cases of type 2 diabetes mellitus undergoing treatment. All subjects were interviewed regarding a full medical history that included age, sex, occupation, duration and family history of diabetes mellitus. The general physical examination procedure included measurement of height, weight, waist circumference and hip circumference. The biochemical parameters such as fasting plasma glucose, serum adiponectin, HDL and triglyceride were measured. Result: The reduction of serum adiponectin in study group was highly significant as compared to control group but its difference between the two subgroups divided based on BMI did not give a statistically significant result. But on correlation of BMI with adiponectin in study group, the correlation coefficient was found to statistically highly significant. Similar correlation of waist-hip ratio (W/H) with adiponectin did not give a significant result. Conclusion: Adiponectin is lowered in obese non-diabetics affecting lipid metabolism showed by increase of LDL and TG and decrease of HDL. In obese diabetics adiponectin is high but dyslipidemia is still present possibly due to improper function of existing serum adiponectin.
Correlation between Serum Adiponectin Levels and Obesity in Women
Background: The role of adiponectin serum concentrations in pathogenesis of obesity is considered an emerging topic issue in clinical biochemistry researches. Objectives: To determine correlation between serum adiponectin levels and obesity. Materials and Methods: We evaluated serum adiponectin levels in 237 non-diabetic women with different degrees of obesity, using enzyme-linked immunosorbent assay (ELISA) after separation of serum from blood samples by centrifuge. Results: Decreasing serum adiponectin levels were significantly associated with degrees of obesity and body fat storage. Discussion: This study suggests that the low serum adiponectin levels have a direct correlation with obesity. However, further studies on large scale populations may be needed, to better understanding the pathobiology of obesity.
Relationship between serum adiponectin and leptin concentrations and body fat distribution
Diabetes Research and Clinical Practice, 2004
The aim of this study was to investigate the relationship between adiponectin and leptin and body fat distribution. One hundred and ninety-seven women participated in this study. Subjects were grouped based on their visceral adipose tissue area (VAT). Body fat distribution was determined by computed tomography. The numbers in the subcutaneous fat dominant group (SFDG) and visceral fat dominant group (VFDG) were 79 and 118, respectively. The VFDG showed lower adiponectin levels than the SFDG (8.9+/-0.4 microg/ml versus 11.4+/-0.7 microg/ml, P=0.006), but leptin levels did not differ significantly between groups (18.8+/-1.1 ng/ml versus 17.7+/-1.8 ng/ml, P=0.111). Adiponectin levels were inversely correlated with fasting insulin, HOMA-IR, triglyceride, SBP and DBP, subcutaneous adipose tissue area (SAT) and VAT, and waist-to-hip ratio (WHR). Leptin levels were positively correlated with fasting glucose and insulin, HOMA-IR, triglyceride, SBP and DBP, VAT and SAT, and WHR (all values of P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05). VAT and HDL-cholesterol were independent variables of adiponectin concentrations (R(2)=0.207, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001), and SAT, fasting insulin, and HOMA-IR were independent variables of leptin concentrations (R(2)=0.498, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001) In conclusion, adiponectin and leptin concentrations, although associated with metabolic parameters, were more strongly influenced by VAT in the case of adiponectin, and by SAT in the case of leptin.
Plasma adiponectin in overweight, nondiabetic individuals with or without insulin resistance
Diabetes, Obesity and Metabolism, 2003
Aim: Adiponectin is a protein produced exclusively by adipocytes with putative insulin-sensitizing and antiatherogenic properties. This cross-sectional study investigated the relationship between plasma adiponectin and a range of anthropometric, glycaemic, lipid and inflammatory parameters in overweight and obese subjects expressing characteristics of the metabolic syndrome. Methods: Subjects were selected for the study from a clinical database, if they were non-diabetic, overweight [body mass index (BMI) > 25] and had features of the metabolic syndrome. The subjects were grouped according to BMI (25-30, 31-35 and >35 kg/m 2 ) and then stratified for insulin resistance [homeostasis model assessment (HOMA) %S]. One hundred and ninety-seven patients (109 males and 88 females) were selected for the study by taking an equal number with the highest and lowest HOMA indices from each of the three BMI groups. Plasma adiponectin concentration was measured in duplicate by radioimmunoassay, and the relationship between these levels and the other parameters was investigated using correlation and multiple linear regression analyses. Results: Plasma adiponectin concentration was higher in females than males (median 10.3 vs. 7.1 mg/ml, p < 0.001) despite being matched for BMI. In both genders, adiponectin levels were inversely related to BMI, waist circumference, percentage body fat, insulin resistance and the fasting plasma concentration of leptin. A direct correlation in both sexes was found between adiponectin levels and high-density lipoprotein (HDL)-cholesterol, apolipoprotein A1 and age. Multiple linear regression analyses showed that the independent determinants of low plasma adiponectin concentrations were gender, age, BMI, insulin resistance and HDL-cholesterol. An association between reduced adiponectin and increased high-sensitivity plasma C-reactive protein concentration was observed only in female subjects and was independent of anthropometric variables. Our observation that adiponectin levels increase with age differs from the majority of other studies and may simply reflect the demographics of the population studied. Conclusions: This study shows that adiponectin is an important molecular link between obesity, insulin resistance and atherogenic lipoproteins. It is possible that plasma adiponectin concentration may be a convenient marker for identifying subjects with the metabolic syndrome who may progress to impaired glucose tolerance. Longitudinal studies are required in order to verify this clinical application of adiponectin.
Serum Levels of Adiponectin in Non-Diabetic and Diabetic Obese Individuals
Iranian Journal of Diabetes and Metabolism, 2007
Background: Adiponectin is an adipose tissue-derived hormone that low levels of this hormone are associated with obesity, insulin resistance, and type 2 diabetes. The aim of this study was to compare the serum levels of adiponectin in diabetic and non-diabetic obese individuals. Methods : As a cross-sectional study 35 obese individuals with type 2 diabetes mellitus and 35 non-diabetic obese subjects were enrolled. Two groups were matched for age, gender and body mass index. Fasting lipid profile was measured via the enzymatic methods. The NycoCard HbA1c Kit was used to measure HbA1c.The Serum Adiponectin, insulin and glucose levels were measured via an enzyme immunoassay, using a commercially available kit and glucose oxidase methods, respectively. The HOMA and QUICKI indices were used to determine insulin resistance and insulin sensitivity, respectively. Results: The mean of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in dia...
The Relationship of adiponectin level and ADIPOQ gene variants with BMI among young adult women
The current study examined the effect of single nucleotide (SNPs) polymorphisms in the ADIPOQ gene (I146T and G276T) on body mass index (BMI) of young adult women. The women were divided into underweight, normal, overweight and obese according to BMI. The circulating levels of adiponectin were measured using commercially available ELISA kits. Genetic polymorphisms were genotyped using the PCR-RFLP method. G276T and I164T SNPs are common in the examined population as the frequency of G allele of 276 SNP was 54.8% and for the T allele of 164 SNP it was 41.7%. Circulating adiponectin levels were related to BMI and were lowest in the obese versus overweight, normal weight and underweight groups (p<0.01). However, ADIPOQ gene SNPs (I146T and G276T) showed no association with BMI groups. In conclusion, the results may suggest that adiponectin level, but not ADIPOQ gene SNPs, is a good indicator to BMI in young adult women.
Istanbul Medical Journal, 2012
Yağ dokusu enerji depolayan ve adiponektin salgılayan aktif bir endokrin organ olarak çalışır. Adiponektin düzeylerinin obezite ve metabolik sendromda azaldığı farkedilmiştir. Bu çalışmanın amacı, obez ve obez olmayan tip 2 diyabetli hastalarda adiponektin düzeylerinin ölçülmesi ve bunun diğer metabolik parametrelerle ilişkisinin değerlendirilmesidir. Gereç ve Yöntem: Çalışmaya hastanemiz diyabet ve endokrinoloji polikliniklerine başvuran 46 obez, 38 obez olmayan hasta alındı. Antropometrik ve metabolik değişkenleri adiponektin düzeyleri ile karşılaştırıldı. Hastaların açlık kan şekeri, tokluk kan şekeri, üre, kreatinin, toplam protein, albümin, toplam kolesterol, LDL-kolesterol, HDL-kolesterol, trigliserid, HbA 1c değerleri spektrofotometrik yöntemle ölçüldü. İnsülin düzeyleri elektrokemilüminesans, adiponektin ise sandviç-ELISA yöntemi ile ölçüldü. Bulgular: Çalışmamızda obez tip 2 diyabetiklerin obez olmayanlara göre daha düşük adiponektin düzeylerine sahip olduğu görüldü (p=0.0001). Adiponektin düzeyleri düştükçe insülin direncinin ve bel çevresinin arttığı saptandı. Bu iki ölçütün adiponektin düzeyini tayin eden ana parametre olduğu gözlendi. Sonuç: İnsülin duyarlılığını arttıran antiyaterojenik ve antienflamatuvar özellikleri olan adiponektin obez diyabetiklerde obez olmayanlara göre düşüktür ve bu durum ateroskleroz riskini arttıran bir faktör olabilir. Anahtar sözcükler: Adiponektin; yağ dokusu; metabolik parametreler; obezite; tip 2 diabetes mellitus. SUMMARY Objectives: Adipose tissue stores energy and acts as an active endocrine organ that secretes adiponectin. It is noted that adiponectin level is decreased in obesity and metabolic syndrome. The aim of this study was to measure the adiponectin levels of obese and non-obese patients previously diagnosed with type-2 diabetes and to evaluate the relationship of adiponectin with other metabolic parameters. Methods: The study included 46 obese and 38 non-obese diabetic patients who were admitted to the Diabetes and Endocrinology Clinics of our hospital. Their anthropomorphic and metabolic parameters were measured and were compared to the adiponectin levels. Fasting blood glucose, postprandial blood glucose, urea, creatinine, total protein, albumin, total cholesterol, LDL, HDL, triglyceride and HbA 1c levels were measured spectrophotometrically. Insulin levels were measured through electrochemiluminescence. Adiponectin was measured by sandwich ELISA technique. Results: Our study revealed that obese type-2 diabetic patients showed lower adiponectin levels in comparison to non-obese ones (p=0.0001). It was shown that the insulin resistance and waist circumference increased while adiponectin levels decreased. It was found that these were the two key parameters determining adiponectin levels. Conclusion: We conclude that adiponectin which increases insulin sensitivity and is known to have anti-inflammatory and anti-atherogenic properties, was found to be lower in obese diabetics as compared to non-obese diabetics and this can be a factor increasing the risk of atherosclerosis.