A rare case of cutaneous granular cell tumour (original) (raw)
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Cutaneous granular cell tumor: A case report
Journal of Pathology of Nepal
Granular cell tumor is a rare benign neoplasm of the skin that accounts for 0.5% of all soft-tissue tumors. Granular cell tumor can affect both sexes and in any age, although it is most common in females. The common locations are the head and neck, the tongue is affected in 25% of cases but any internal organs can be affected such as soft tissue, bronchus, stomach, rectum, anus, biliary ducts. Here, we report a 58-year-old female patient who presented with a 4-year history of a slowly growing mass, with a dimension of 5 × 4 cm on her left waist, diagnosed as a Granular cell tumor at histopathological examination.
Primary Cutaneous Malignant Granular Cell Tumor
The American Journal of Dermatopathology, 2015
Granular cell tumors (GCTs) are uncommon soft tissue tumors characterized by cytoplasmic granular appearance of the neoplastic cells. Malignant granular cell tumors (MGCTs) comprise less than 2% of GCTs and are mostly found in the subcutaneous soft tissues of the lower extremities, especially the thighs. Very few cases have been reported in the skin. The uncommon occurrence of cutaneous MGCTs and their histopathologic similarities with their benign counterpart make difficult the diagnosis of this particular malignancy. We describe a primary cutaneous MGCT that presented as a left posterior chest wall mass in a 51-year-old woman. Local excision was performed for the primary tumor, which was first interpreted as an atypical GCT, but 3 months later a left axillary mass appeared, and subsequent axillary lymph node dissection demonstrated metastatic disease in 4 of 12 excised lymph nodes. We report the immunophenotype of this primary cutaneous MGCT, which was studied with an ample panel of antibodies and compare our results with those of the few previously reported cases in the skin and subcutaneous soft tissues.
Dermal nonneural granular cell tumor: a case report
Journal of Surgical Case Reports
Dermal nonneural granular cell tumor is a rare neoplasm of uncertain histogenesis that Le Boit and colleagues originally described in 1991. It arises commonly from the back, extremities and head and neck. To the best of our knowledge, only 50 cases have been reported in adults in the English literature. A 42-year-old man presented with a polypoid skin nodule of the front side of the chest wall, measuring 1,8 × 1,5 cm. The lesion was removed completely with tumor-free margins. Microscopically, the tumor was composed of a diffuse infiltrate of polygonal cells, S 100 negatives, with abundant granular cytoplasm and vesicular nuclei. The diagnosis of dermal nonneural granular cell tumor was retained. No recurrence was noted during follow up of 6 months. The prognosis is good.
Cutaneous Granular Cell Tumor of the Breast: A Clinical Diagnostic Pitfall
Journal of Clinical …, 2010
We report the clinical-morphological study of a granular cell tumor in dermal/hypodermal junction and subcutaneous fat left breast of an 83-year-old woman with a family history of breast carcinoma. Mammography study showed a spiculated lesion in the lower inner quadrant ...
Granular cell tumour of the soft tissues: a case report and literature review
International seminars in surgical oncology : ISSO, 2006
Granular cell tumours (GCT) of the soft tissues are rare benign tumours but some time may be difficult to distinguish from malignant neoplasms. It is important that clinicians are aware of their existence. We present a new case of GCT of the soft tissues followed by a brief review of literature.
Case Reports in Pathology, 2016
Granular cell tumor (GCT) is a Schwann cell related benign neoplasm of soft tissue. GCT is an uncommon entity that occurs in a wide variety of body sites, but it is generally presented in the skin, oral cavity, superficial soft tissue, and respiratory and digestive tracts. Most of the GCTs are benign but clinically and radiologically these may mimic malignancy. Histopathological diagnosis is gold standard for establishing the true nature of the lesion. GCT is most commonly solitary but in about 10% of cases can be multifocal, usually involving various skin and soft tissue sites versus involving various internal sites. Therefore, these can involve skin and soft tissue or submucosa and viscera. GCT is usually benign; however, local recurrence is common due to incomplete removal. Malignant cases are rarely reported in 1-2% of cases. In this study, we report clinical and histopathological findings of a 36-year-old woman with metachronous GCT in breast and scalp. The clinical features ra...
Granular cell tumor: An uncommon benign neoplasm
Indian Journal of Dermatology, 2015
Granular cell tumor is a distinctly rare neoplasm of neural sheath origin. It mainly presents as a solitary asymptomatic swelling in the oral cavity, skin, and rarely internal organs in the middle age. Histopathology is characteristic, showing polyhedral cells containing numerous fine eosinophilic granules with indistinct cell margins. We present a case of granular cell tumor on the back of a 48-year-old woman which was painful, mimicking an adnexal tumor. Figure 1: Well-defined, yellowish hard nodular lesion with smooth irregular surface over midline in the upper back [Downloaded free from http://www.e-ijd.org on Wednesday, May 06, 2015, IP: 223.223.143.253] Gayen, et al.: Granular cell tumor
Granular cell tumor: Case report
Journal of the Saudi Society of Dermatology & Dermatologic Surgery, 2011
Granular cell tumor (GCT) is uncommon, mostly benign neoplasm that can affect any organ of the body; immunohistochemical studies showed that it has a Schwann cell origin through the positive identification of S-100 protein. GCT can affect both sexes and in any age, although it is most common in females and dark skinned population. The most common occurrence is during the fourth to sixth decades of life, very rarely it occurs as congenital disease. The common locations are the head and neck, the tongue is affected in 25% of cases but any internal organs can be affected such as larynx, bronchus, stomach, rectum, anus, biliary ducts, pancreas and soft tissues. Malignant GCT is extremely rare, it occurs in only 1-2% of cases. Multiple GCTs occur up to 10%. In children, only 20 cases have been reported in the literature. This paper describes the case of a 6-year-old girl diagnosed with upper right arm granular cell tumor and the patient's clinical evolution after tumor surgical removal.
Large Dermal Non Neural Granular Cell Tumor on the Surgical Wound Site
Annals of Dermatology, 2011
Granular cell tumors (GCTs) can be divided into neural type with S-100 reactivity and non-neural type without that. The latter has not been widely recognized and there are only fewer reports available when compared to conventional GCT. A 65-year-old man was presented with the presence of a painless mass on his back. The mass had developed into a small nodule on the scar developed because of previous surgery carried out 2 years ago. The tumor consisted of large, polygonal cells comprising of an enormous number of faintly eosinophilic small granules in the cytoplasm. The cytoplasmic granules were stained positively for periodic acid-Schiff stain. Immunohistochemical stains for S-100 protein and neuron-specific enolase were found to be negative. Herein, we report the appearance of a very rare case of non neural GCT developed on the surgical scar in support with relevant literature reviews. (Ann Dermatol 23(S2) S147∼ S150, 2011