Dermal nonneural granular cell tumor: a case report (original) (raw)

Cutaneous granular cell tumor: A case report

Journal of Pathology of Nepal

Granular cell tumor is a rare benign neoplasm of the skin that accounts for 0.5% of all soft-tissue tumors. Granular cell tumor can affect both sexes and in any age, although it is most common in females. The common locations are the head and neck, the tongue is affected in 25% of cases but any internal organs can be affected such as soft tissue, bronchus, stomach, rectum, anus, biliary ducts. Here, we report a 58-year-old female patient who presented with a 4-year history of a slowly growing mass, with a dimension of 5 × 4 cm on her left waist, diagnosed as a Granular cell tumor at histopathological examination.

Primary Cutaneous Malignant Granular Cell Tumor

The American Journal of Dermatopathology, 2015

Granular cell tumors (GCTs) are uncommon soft tissue tumors characterized by cytoplasmic granular appearance of the neoplastic cells. Malignant granular cell tumors (MGCTs) comprise less than 2% of GCTs and are mostly found in the subcutaneous soft tissues of the lower extremities, especially the thighs. Very few cases have been reported in the skin. The uncommon occurrence of cutaneous MGCTs and their histopathologic similarities with their benign counterpart make difficult the diagnosis of this particular malignancy. We describe a primary cutaneous MGCT that presented as a left posterior chest wall mass in a 51-year-old woman. Local excision was performed for the primary tumor, which was first interpreted as an atypical GCT, but 3 months later a left axillary mass appeared, and subsequent axillary lymph node dissection demonstrated metastatic disease in 4 of 12 excised lymph nodes. We report the immunophenotype of this primary cutaneous MGCT, which was studied with an ample panel of antibodies and compare our results with those of the few previously reported cases in the skin and subcutaneous soft tissues.

A rare case of cutaneous granular cell tumour

International Journal of Research in Medical Sciences, 2021

Granular cell tumors are uncommon tumors of uncertain etiology. It accounts for approximately 0.5% of all soft tissue tumors. However, the involvement of skin is rare. Only few cases of cutaneous granular cell tumor is reported till date. Here, we present a case of cutaneous granular cell tumor in a 48 years female patient.

Large Dermal Non Neural Granular Cell Tumor on the Surgical Wound Site

Annals of Dermatology, 2011

Granular cell tumors (GCTs) can be divided into neural type with S-100 reactivity and non-neural type without that. The latter has not been widely recognized and there are only fewer reports available when compared to conventional GCT. A 65-year-old man was presented with the presence of a painless mass on his back. The mass had developed into a small nodule on the scar developed because of previous surgery carried out 2 years ago. The tumor consisted of large, polygonal cells comprising of an enormous number of faintly eosinophilic small granules in the cytoplasm. The cytoplasmic granules were stained positively for periodic acid-Schiff stain. Immunohistochemical stains for S-100 protein and neuron-specific enolase were found to be negative. Herein, we report the appearance of a very rare case of non neural GCT developed on the surgical scar in support with relevant literature reviews. (Ann Dermatol 23(S2) S147∼ S150, 2011

Granular cell tumor: An uncommon benign neoplasm

Indian Journal of Dermatology, 2015

Granular cell tumor is a distinctly rare neoplasm of neural sheath origin. It mainly presents as a solitary asymptomatic swelling in the oral cavity, skin, and rarely internal organs in the middle age. Histopathology is characteristic, showing polyhedral cells containing numerous fine eosinophilic granules with indistinct cell margins. We present a case of granular cell tumor on the back of a 48-year-old woman which was painful, mimicking an adnexal tumor. Figure 1: Well-defined, yellowish hard nodular lesion with smooth irregular surface over midline in the upper back [Downloaded free from http://www.e-ijd.org on Wednesday, May 06, 2015, IP: 223.223.143.253] Gayen, et al.: Granular cell tumor

Granular cell tumor: A clinicopathologic study of 110 patients

Journal of Surgical Oncology, 1980

The clinicopathologic features of 1 18 granular cell tumors (GCT) encountered at two affiliated hospitals were reviewed. A total of 1 1 0 patients were affected over this 32-year period of study (7 1 men, 39 women), and in 5% GCT were multiple. Patients ranged in age from 16 t o 58 years (average 32 years) and were symptomatic for an average duration of 11 months prior t o diagnosis. There was a greater than expected frequency of GCT among black patients (29%). Although tongue was the single most common anatomic site involved, relatively more GCT (44%) occurred in skin o r subcutaneous tissue. Less common locations were breast parenchyma (10 cases), rectal mucosa and anus (6), vulva (4), esophagus and larynx (2 cases each). The correct preoperative diagnosis of this protean tumor was made in only three patients. GCT were surgically treated with the average diameter of resected tumor being 1.2 cm (range 0.2-3.5 cm). Pseudoepitheliomatous hyperplasia was noted in 11 tumors and in one vulvar GCT there was overlying in situ squamous cell carcinoma. Tumors were incompletely excised in 24 of 5 6 patients having adequate followup; only five of these 24 patients experienced a local recurrence of tumor. Malignant behavior was not observed. Results of histochemical and ultrastructural study are briefly discussed. The precise histogenesis of GCT is uncertain but Schwann cell origin is favored in most cases.

Granular cell tumour: malignant or benign?

Singapore Medical Journal, 2015

A granular cell tumour (GrCTs) is a rare, benign, soft tissue tumour (1) that likely arises from Schwann cells. (2) Although it was initially classified as a myoblastoma, recent studies agree that it is more likely to be neural in origin. (2,3) GrCTs, although typically found in the tongue or the dermal and subcutaneous regions, can appear at any location. (2) GrCTs are rarely found in the extremities. Approximately 0.5%-2.0% of GrCTs are reported as malignant. (1) A malignant GrCT is aggressive and has a poor prognosis, (4) whereas a benign lesion has excellent outcomes after surgical resection. (1) Malignant GrCTs have a high rate of metastasis and recurrence, with a mortality rate of 40%. (2) Thus, differentiating a malignant tumour from a benign tumour is important. A malignant lesion can be suspected on clinical presentation and confirmed via histopathological examination using the Fanburg-Smith criteria. (4,5) We herein report a case series of five patients who were diagnosed with GrCT of the extremities at University Malaya Medical Centre, Kuala Lumpur, Malaysia. The clinical presentation, and histopathological and immunohistochemical results of these five cases were evaluated. METHODS This study was a retrospective review of all cases of GrCT of the extremities who presented at the

Granular cell tumor: Case report

Journal of the Saudi Society of Dermatology & Dermatologic Surgery, 2011

Granular cell tumor (GCT) is uncommon, mostly benign neoplasm that can affect any organ of the body; immunohistochemical studies showed that it has a Schwann cell origin through the positive identification of S-100 protein. GCT can affect both sexes and in any age, although it is most common in females and dark skinned population. The most common occurrence is during the fourth to sixth decades of life, very rarely it occurs as congenital disease. The common locations are the head and neck, the tongue is affected in 25% of cases but any internal organs can be affected such as larynx, bronchus, stomach, rectum, anus, biliary ducts, pancreas and soft tissues. Malignant GCT is extremely rare, it occurs in only 1-2% of cases. Multiple GCTs occur up to 10%. In children, only 20 cases have been reported in the literature. This paper describes the case of a 6-year-old girl diagnosed with upper right arm granular cell tumor and the patient's clinical evolution after tumor surgical removal.

A case report of a rare intramuscular granular cell tumor

Diagnostic Pathology, 2015

Background: Granular cell tumors (GCTs) were firstly described by Weber in 1854 and 70 years later by Abrikossoff and classified as benign tumors. Originally considered muscle tumors, they have been identified as neural lesions, due to their close association with nerve and to their immunohystochemical characteristics. GCTs are uncommon tumors and they may arise in any part of the body; they have been mainly observed in tongue, chest wall and upper extremities; less frequent sites are larynx, gastrointestinal tract, breast, pituitary stalk and the female anogenital region. Here we report a case of GCT showing an uncommon localization such as the upper third of the right rectus muscle of the abdominal wall. Case presentation: A 45 year-old woman of Caucasian origin presented to the surgeon with a 6-month history of light pain in the upper third of the abdominal wall. Radiological exams (Ultrasonography, Computed Tomography and Contrast magnetic resonance imaging) showed a localized in the right rectus abdominis muscle. After excision, histological and immunohystochemical analysis, with the support of electron microscopy, allowed making diagnosis of granular cell tumor. Discussion: After fist description by Abrikosoff in 1926 of GCT like mesenchymal tumor of unknown origin, in recent years immunohystochemical techniques definitely demonstrated the histogenetic derivation of GCT from Schwann cells. Granular cell tumors are rare, small, slow-growing, solitary and painless subcutaneous nodules which behave in a benign fashion, but can have a tendency to recur; in rare cases they can metastasize, when they became malignant; there are some clinical and histological criteria to suspect the malignance of this tumor. Conclusion: It is important that clinicians, radiologists and pathologists are aware of the clinical presentation and histopathology of GCT for appropriate management, counselling and follow-up. In our case we had a complete radiological, morphological and immunohystochemical characterization of the lesion and a definitive diagnosis of benignity confirmed by electron microscopy.