Interleukin-21 Receptor Blockade Inhibits Secondary Humoral Responses and Halts the Progression of Preestablished Disease in the (NZB × NZW)F1 Systemic Lupus Erythematosus Model (original) (raw)

IL-21R blockade inhibits secondary humoral responses and halts the progression of pre-established disease in NZB/W F1 systemic lupus erythematosus

Palaniswami Rathanaswami

Arthritis & rheumatology (Hoboken, N.J.), 2015

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A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

Rosanne Spolski

Proceedings of the National Academy of Sciences, 2009

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IL-21 Is a Double-Edged Sword in the Systemic Lupus Erythematosus–like Disease of BXSB.Yaa Mice

Thomas Sproule

Journal of Immunology, 2013

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Therapy implications for the role of IL-21 in lupus

davide di fusco

Expert Review of Clinical Immunology, 2016

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IL-21 Is a Double-Edged Sword in the Systemic Lupus Erythematosus-like Disease of BXSB.Yaa Mice

Thomas Sproule

The Journal of Immunology, 2013

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IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice

Quintus Medley, Heath Guay

The Journal of Immunology, 2012

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The role of IL-21 in regulating B-cell function in health and disease

Stefan Kuchen

Immunological Reviews, 2008

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IL-21 Mediates Suppressive Effects via Its Induction of IL-10

Rosanne Spolski

The Journal of Immunology, 2009

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Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

Martin Hegen

Arthritis & Rheumatism, 2007

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Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease

Thomas Sproule

Cell reports, 2017

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In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus

Yulia Vugmeyster

mAbs

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Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus

Johanna Westra, Wayel Abdulahad

Arthritis Research & Therapy, 2011

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IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage inlyn−/−mice

Toñi Gutiérrez

European Journal of Immunology, 2012

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In vivo and in vitro roles of IL-21 in inflammation

Denis Girard

The Journal of Immunology, 2004

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Interleukin-21 Receptor Might be a Novel Therapeutic Target for the Treatment of Rheumatoid Arthritis

farhad seif

Journal of Experimental & Clinical Medicine, 2014

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IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from human marginal zone B cells as well as from circulating peripheral blood B cells from autoimmune patients

A. Grammer

Arthritis Research & Therapy, 2007

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Biological Functions of Interleukin-21 and Its Role in Inflammation

Denis Girard

The Scientific World JOURNAL, 2007

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Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

Rosanne Spolski

Nature Reviews Immunology, 2005

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Inflammation In Vivo and In Vitro Roles of IL-21 in

Denis Girard

2004

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A Critical Role for IL-21 in Regulating Immunoglobulin Production

Rosanne Spolski

Science, 2002

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Assessing Agonistic Potential of a Candidate Therapeutic Anti-IL 21 R Antibody

Renee Ramsey

Journal of …, 2010

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Faculty of 1000 evaluation for The cellular source and target of IL-21 in K/BxN autoimmune arthritis

Jason McDougall

F1000 - Post-publication peer review of the biomedical literature, 2014

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IL-21 Counteracts the Regulatory T Cell-Mediated Suppression of Human CD4+ T Lymphocytes

Monica Boirivant

The Journal of Immunology, 2007

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IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 Response

Ilkka Julkunen

The Journal of Immunology, 2002

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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Wenda Gao

Nature, 2007

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Essential autocrine regulation by IL21 in the generation of inflammatory T cells

Li Ma

Nature, 2007

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IL-21: a novel IL-2–family lymphokine that modulates B, T, and natural killer cell responses

Tarek Habib

Journal of Allergy and Clinical Immunology, 2003

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Overexpression of IL‐21 promotes massive CD8+ memory T cell accumulation

Juju Gmail

European journal of …, 2007

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Interleukin-21: a multifunctional regulator of immunity to infections

Maureen a. Cox

Microbes and Infection, 2010

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The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer

Rosanne Spolski

Current Opinion in Immunology, 2008

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A Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4+CD25- T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice

Eunkyeong Jang

The Journal of Immunology, 2009

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