An Unusual Finding of Tumorlet Carcinoid and Endobronchial Hamartoma in the Lobar Bronchus (original) (raw)
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Medicine, 2016
Hamartomas are very rarely identified as an endobronchial lesion. Herein, we describe a peculiar case of a 55-year-old woman with persistent cough and increasing dyspnea and radiological detection of a solid lesion subtotally occluding the main right bronchus. Despite the radiological and radiometabolic (18-fluoro-2-deoxy-d-glucose positron emission tomography/computer tomography scan) features were highly suspected for bronchial carcinoid, the definitive diagnosis after endoscopic removal was indicative of an endobronchial hamartoma. When considering differential diagnosis of an endobronchial lesion, the physicians should take firmly in mind such rare entity and, accordingly, bronchoscopy and bronchoscopic biopsy should be done as first step in management of all cases presenting with endobronchial lesions.
Oncology Research and Treatment, 2014
Neuroendocrine tumors (NETs; syn. carcinoid tumors) are highly or moderately differentiated neoplasms. They comprise a large variety of rare and heterogeneous tumors with an estimated incidence of 3-5/100,000/year. They can arise in virtually every internal organ, but mainly occur in the gastroenteropancreatic and bronchopulmonary systems. Around 25% of the NETs are localized in the bronchopulmonary system. Approximately 2% of all lung tumors are NETs. According to the World Health Organization (WHO) classification of lung tumors, bronchopulmonary NETs are subdivided into typical carcinoids (TCs) and atypical carcinoids (ACs). The parameter with the highest impact on NET behavior and prognosis is the histological classification and staging according to the tumor/node/metastasis (TNM) system. The diagnosis of NETs is established by histological examination and the immunohistochemical detection of general neuroendocrine markers, such as chromogranin A (CgA) and synaptophysin. Serum ma...
Disseminated typical bronchial carcinoid tumor
Vojnosanitetski pregled, 2013
Introduction. Bronchial carcinoids belong to a rare type of lung tumors. If they do not expose outstanding neuroendocrine activity, they develop without clearly visible symptoms. They are often detected during a routine examination. According to their clinical pathological features, they are divided into typical and atypical tumors. Typical bronchial carcinoids metastasize to distant organs very rarely. Localized forms are effectively treated by surgery. The methods of conservative treatment should be applied in other cases. Case report. We presented a 65-year-old patient with carcinoid lung tumor detected by a routine examination. Additional analysis (chest X-ray, computed tomography of the chest, ultrasound of the abdomen, skeletal scintigraphy, bronhoscopy, histopathological analysis of the bioptate of bronchial tumor, as well as bronchial brushing cytology and immunohistochemical staining performed with markers specific for neuroendocrine tumor) proved a morphologically typical ...
Bronchial carcinoid tumors: A retrospective analysis of 126 patients
The Annals of Thoracic Surgery, 1992
cases of primary carcinoma of the lung were diagnosed at the Duke University Medical Center. During the same period, 126 patients (mean age, 53 f 13 years) were diagnosed with bronchial carcinoid. The overall survival was 78% for 5 years and 71% for 10 years. Surgical treatment in 106 patients included pneumonectomy (15), lobectomy (63 with 9 bronchoplastic procedures), stapled wedge resection (221, and bronchoscopic laser resection (6). The method of diagnosis was chest roentgenography (1211, chest computed tomography (77), mediastinal tomography (31), bronchoscopy (Sl), bronchoscopic brushing and washing (501, bronchoscopic biopsy (40), transthoracic needle biopsy (271, thoracotomy (loo), and autopsy (5). Univariate analysis of the medical history, presenting signs and symptoms, diagnostic test results, and pathologic data predicted improved survival (p < 0.001) for: female sex (n = 581, lthough bronchial carcinoid tumors were described A in the 1800s, it was Seigfreid Oberndorfer [l] who coined the term Karzinoide or "resembling carcinoma" in 1907. In 1930, Kramer grouped carcinoid tumors with cylindromas as bronchial adenomas because of their good prognosis compared with bronchogenic carcinoma. It later became apparent that there was a subset of carcinoid adenomas that were more aggressive and therefore were designated as "atypical" by Arrigoni and associates [3] in 1972. Over the last 30 years, several series of bronchial carcinoid tumors have appeared in the literature, but none of substantial size has described this clinical entity in detail with an emphasis on univariate and multivariate survival analysis in the modern era of immunocytochemistry, electron microscopy, and chemotherapy. asymptomatic presentation (n := 47), normal serum serotonin or urinary hydroxyindoleacetic acid levels (n = 76), peripheral location of the primary tumor (n = 50), pathologic stage I or I1 (n = 91), negative lymph nodes (n = 80), primary tumor 2 cm or less in diameter (n = 671, and typical histology (n = 80). No significance ( p > 0.1) was
Pulmonary Carcinoid Tumour of Endobronchial Presentation: A Case Report
Introduction: Lung carcinoid tumors account for 1-2 % of malignant lung neoplasms. Early diagnosis is crucial, and surgery at an early stage may improve the clinical picture and may even be a curative option. Case report: We present the case of a 78-year-old woman with a history of poorly controlled arterial hypertension, anxious syndrome, irritable bowel syndrome, and paroxysmal palpitations for the last two years. Imaging showed a left hilar nodular lesion causing endobronchial obstruction in the left lower lobe. Anatomopathology revealed a low-grade pulmonary neuroendocrine tumor, and pulmonary resection with nodal staging was promptly considered. Conclusions: The diagnosis of pulmonary carcinoid tumor is challenging; therefore, it is necessary to maintain suspicion in patients with non-specific and/or persistent respiratory symptoms, and complete resection and prolonged close follow-up should be considered despite a satisfactory postoperative course.
Carcinoid tumor with localized bronchiectasis
Tanaffos, 2013
Bronchial carcinoid tumor comprises 1 to 3% of lung neoplasms. The common age of onset is mainly post-puberty although atypical carcinoid tumors occur at ages 44 to 55. Carcinoid tumors cause two groups of symptoms in patients: symptoms due to obstruction and symptoms due to the production and release of active neuropeptides. Histologically, carcinoid tumors are categorized into two groups of typical and atypical while in terms of location of lesion, they are grouped into central and peripheral types. Differentiation between malignant and benign carcinoid tumors is based on presence or absence of metastasis. Bronchoscopy and endobronchial biopsy are the best diagnostic measures in these patients. Serologic evaluation and assessment of active metabolites in case of liver metastasis also help the diagnosis. Surgical resection is the treatment of choice for this condition. This report discusses a patient with carcinoid tumor who was receiving bronchodilator treatment for a couple of mo...
Bronchial carcinoid tumors: A rare malignant tumor
Nigerian Journal of Clinical Practice, 2015
Bronchial carcinoid tumors (BCTs) are an uncommon group of lung tumors. They commonly affect the young adults and the middle aged, the same age group affected by other more common chronic lung conditions such as pulmonary tuberculosis. Diagnosis is commonly missed or delayed due to a low index of suspicion. Surgery is the mainstay of treatment with an excellent outcome. There are many reports of this rare group of tumors in the Western and Asian regions. The only report around our sub-region is a post mortem report of an atypical variant. We wish to report a case of the typical variant and increase our index of suspicion. A 25-year-old male presented with a 4 years history of cough and haemoptysis. He was repeatedly treated for bronchial asthma and pulmonary tuberculosis with no improvement of symptoms. Chest X-ray and chest computed tomography scan revealed a left upper lobe tumor. Histology reported a typical variant of BCT which was confirmed by immunohistochemistry. He had a left upper lobectomy and has done excellently well thereafter. A high index of suspicion is needed to reduce the risk of missing or delaying the diagnosis.
Neuroendocrine syndrome in bronchial carcinoid tumors
Experimental and Therapeutic Medicine, 2020
Pulmonary carcinoid tumors represent bronchopulmonary neuroendocrine neoplasms which might synthetize serotonin, histamine, bombesin or other types of hormones responsible for the development of a broad spectrum of signs and symptoms, known as carcinoid syndrome. Data of 98 patients submitted to surgery for bronchial carcinoid tumors in the Thoracic Surgery Clinic of the 'Marius Nasta' Institute of Pneumophtisiology between 2014 and 2018 were retrospectively reviewed. All patients were submitted to paraclinical tests, imagistic studies (computed tomography or magnetic resonance imaging), bronchoscopy and biopsy in order to have a positive diagnostic of pulmonary carcinoid. The most common clinical symptoms at the time of presentation were: Persistent cough followed by dyspnea and recurrent pulmonary infections. The main neuroendocrine syndromes found were Cushing and Carcinoid Syndrome. All patients were submitted to surgery with curative intent consisting of wedge resection (in 4 cases, 4.08%), lobectomy (in 79 cases, 80.61%), bilobectomy (in 5 cases, 5.1%) and pneumonectomy respectively (in 10 cases, 10.2%). In all cases neuroendocrine specific symptoms disappeared once the carcinoid tumor was removed. In conclusion, bronchial carcinoid tumors have a positive outcome in most cases. Specific neuroendocrine markers as well as neuroendocrine syndrome disappears once the tumor is removed.