Association of vitamin D deficiency with poor glycaemic control in diabetic patients (original) (raw)
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Journal of Evolution of Medical and Dental Sciences, 2017
BACKGROUND Vitamin D deficiency is widely prevalent across all ages, races, geographical regions and socioeconomic strata. There is ample evidence indicating role of vitamin D in insulin secretion and insulin resistance in patients with type 2 diabetes mellitus. Evidence shows that Vitamin D deficiency can affect the glycaemic control in type 2 diabetes mellitus. Objective-To study the association between serum 25-hydroxyvitamin D levels with glycaemic control in patients of type 2 diabetes mellitus. MATERIALS AND METHODS This case series study was performed on 50 consecutive patients of type 2 diabetes mellitus of 30 to 60 years admitted in General Medicine Ward at Goa Medical College. Serum 25-hydroxyvitamin D levels were assessed using Fully Automated Chemiluminescent Immunoassay (CLIA). Patients with renal failure, type 1 diabetes, chronic illness, pregnancy, thyroid disorders and previous intake of calcium and vitamin D were excluded from the study. The relationship between serum 25-hydroxyvitamin D levels and HbA1c, fasting blood glucose and postprandial blood glucose levels was assessed. RESULTS 72% of the study population had vitamin D deficiency and 26% of the study group had insufficiency of the vitamin and the remaining 2% had normal 25-hydroxyvitamin D levels. The type 2 diabetic individuals with vitamin D deficiency showed a poor glycaemic control as evidenced by inverse relationship of serum vitamin D levels with FBSL and PPBSL values. There was inverse association between the low serum 25-hydroxyvitamin D levels and elevated HbA1c in the study population. CONCLUSION Vitamin D deficiency may be associated with impairment of glycaemic control in type 2 diabetes mellitus.
European Journal of Cardiovascular Medicine, 2023
Introduction: Diabetes mellitus is one of the common non-communicable diseases in India. Role of vitamin D is described in diabetes mellitus in multiple studies owing to its facilitation/inhibition of transcription factor and immune-modulator property. Aim: To study the association between vitamin D level and HbA1C level. Methods: It was an analytical observational case study. Patients of type 2 diabetes mellitus were included in the study. All routine lab parameters were done and patients were evaluated for diabetic retinopathy and neuropathy. Statistical analysis was done by pearson correlation test, fisher's exact test and ANOVA. Linear regression analysis was also done. Results: 119 patients were included in the study. Vitamin D deficiency was found in 77 patients (64.71%). Significant association was found between vitamin D deficiency and younger age. (p = 0.012) Negative correlation was present between vitamin D level and HbA1c. Vitamin D deficiency was found to be significantly associated with high HbA1c (p = 0.024). Conclusion: Vitamin d deficiency in type 2 diabetes mellitus is associated with poor glycemic control.
Association of serum Vitamin D level with Glycemic Status in Patients of Type 2 Diabetes Mellitus
Endocrinology & Metabolic Syndrome
Introduction: For development of Type 2 Diabetes mellitus, Vitamin D is thought to be a risk factor. Various studies have established the fact that Vitamin D replenishment improves glycemic status and insulin secretion in patients with Type 2 Diabetes mellitus with established hypovitaminosis D. This study was done to find out the degree of association between glycemic status and vitamin D levels in type 2 Diabetes Mellitus patients in a tertiary care center. Patient and methods: The study was done in the Department of Biochemistry, SCB Medical College, and Cuttack 48 patients of type 2 Diabetes Mellitus were taken as cases 42 healthy subjects were taken as controls. Biochemical parameters like FBS, PPBS, Urea, Creatinine, HbA1c, Lipid profile parameters were measured in both cases and controls. Results: The serum urea and creatinine levels were significantly elevated in complicated type 2 Diabetes mellitus patients as compared to healthy controls. Serum cholesterol, triglycerides, LDL Cholesterol levels also showed significant increase Vitamin D and FBS levels showed a significant negative correlation in cases and vitamin D levels were decreased in cases as compared to controls. Conclusion: As Vitamin D and FBS levels showed a significant negative correlation, and vitamin D levels were decreased in cases as compared to controls, so it can be proved that vitamin D can lead to good glycemic control and hypovitaminosis D can thereby lead to Type 2 Diabetes Mellitus.
Integrative Journal of Medical Sciences, 2020
Background: Vitamin D deficiency is widespread and coexisted with diabetes. However, the relation between Vitamin D level and glycemic control is not yet fully understood. This study examines the correlation between vitamin D level and glycemia indicators and diabetic microvascular complications.Methods: The study is a cross-sectional study, had been done at the outpatient department in Najran university hospital, Saudi Arabia from May 2019 to February 2020. 220 patients recruited by simple random sampling.Results: 60% of diabetes (n-130) had been using oral anti-glycemic medications, though most of them had uncontrolled glycemic status and had got microvascular complications. It is notable that among diabetes having a low vitamin D level; 55.5% had high FBS, 45.6% had high RBS and 65% had high HBA1C. Besides,17% have retinopathy, 16.6% have nephropathy, 26.2% have peripheral neuropathy and 1.9% have a diabetic foot.Conclusion: The clinical and laboratory assessments are essential t...
Journal of Medical Sciences
Objective: To find a possible association between levels of vitamin D and glycosylated hemoglobin levels in patients with type II diabetes mellitus. Materials and Methods: A cross-sectional study was conducted at a tertiary care hospital in Peshawar over six months. Diagnosed cases of Type-II diabetes mellitus were recruited through non-probability consecutive sampling. The levels of glycosylated hemoglobin and serum vitamin D levels were assessed in 219 selected patients enrolled in the study through Cobas Integra 800 and Enzyme-Linked Immunosorbent Assay respectively. Patients were divided into three categories based on increasing levels of glycosylated hemoglobin. The trend in the levels of vitamin D levels in these categories of increasing HbA1c was identified. Results: Out of 219 Type II diabetic patients, 30.1% (66) were men while 69.9% (153) were women. The mean age was 59.48 ± 9.29 years. Si...
Correlation between Vitamin D and HbA1C in Type 2 Diabetic patients
Background: The role of Vitamin D in various metabolic disorders including Diabetes Mellitus has been explored. Vitamin D has sparked widespread interest in the pathogenesis and prevention of diabetes. Aim: This study evaluates the correlation between Vitamin D status and Glycated haemoglobin in Type 2 Diabetes Mellitus. Material and methods: This study was a prospective case control study with 50 cases and 50 controls. Results: Vitamin D insufficiency was observed in both cases and controls. The mean Vitamin D values in cases and controls were 13.89+6.28ng/ml and 17.30+11.13ng/ml respectively. Chi square test shows there is significant statistical difference in Vitamin D levels between cases and controls but inverse correlation between Vitamin D and HbA1C which was not found statistically significant. Conclusion: Present study shown the inverse correlation between Vitamin D and HbA1C but it didn't came statistically significant, may be due to small sample size. Hence present study cannot establish the role of Vitamin D in preventing Diabetes Mellitus but it is highly recommended for Vitamin D screening in diabetic patients on a regular basis.
Association among Vitamin D Deficiency, Type 1 Diabetes Mellitus and Glycemic Control
Journal of Diabetes & Metabolism, 2015
Background: Studies have identified that the deficiency of vitamin D is strongly connected with diabetes mellitus type 1. Vitamin D has the capability to control increased blood glucose level. Purpose: The study appraises the association among vitamin D deficiency, type 1 diabetes mellitus, and glycated hemoglobin among children. Methods: Around, 226 diabetic children were selected for this retrospective study from outpatient department of King Abdul Aziz University Hospital. Majority of the participants were female individuals, with the rate of 61.1% and were divided into three categories, based upon the rate of vitamin D deficiency. Every participant of the study was taking intensive insulin therapy. Results: The findings of the study have shown that 77% of the diabetic patients had reduced level of vitamin D in total. The study identified, from the evaluation between HbA1c control and vitamin D status, that 66% of the diabetic and vitamin D deficient participants were poorly controlled (HbA1c>9%). Conclusion: Vitamin D deficiency among the patients of diabetes mellitus type 1 was extremely high and was closely related with glycemic control. Additionally, the findings of the study have demonstrated therapeutic implications that the supplements of vitamin D have the potential to manage glucose level.
Prevalence of vitamin D deficiency in type 2 diabetics and its association with glycemic control
2021
Background: Optimal glycaemic control in type 2 diabetics is of utmost importance in preventing the complications of diabetes which lead to increased morbidity and mortality related to the disease. Some studies have shown that vitamin D deficiency was prevalent in type 2 diabetic patients and was associated with poor glycaemic control. This study aimed to determine the vitamin D3 levels in type 2 diabetic patients and its association with glycaemic control. Patients and methods: This cross sectional study was carried out in the outdoor department of Medical Unit II of Sir Ganga Ram Hospital/Fatima Jinnah Medical University Lahore from Feb 10, 2019 to May 9, 2019. A total of 45 cases of type 2 diabetes mellitus were enrolled in this study after taking informed consent from them. Demographic details (name, age, gender, including duration of diabetes) were obtained and blood sample were taken for HbA1c and 25-OH vitamin D3 levels. Vitamin D deficiency was diagnosed by taking serum leve...
Association Of Vitamin D Status And Diabetes Mellitus
2012
To evaluate the association of 25-hydroxyvitamin D3 (25OHD)inadequacyand hyperglycaemia in a Pakistani adult population.Study Design:Case control studyPlace & Period of Study:Department of Pathology, PNS SHIFA Hospital, Karachi; Aug 2011 to Nov 2011.Method and Material:Plasma Glucose levels were measured in 86 patients divided on the basis of their 25-hydroxyvitamin D3(25OHD)levels in three groups, normal (>31 ng/ml), insufficient (20-31ng/ml) and deficient (<20ng/ml). Vitamin D insufficiency (VDI)and Vitamin D Deficiency (VDD) are collectively called Vitamin D inadequacy. 25OHD was measured by electrochemiluminescenceusing Roche Elecsys® Systems while glucose was estimated by routine methods on Roche Hitachi® Autoanalyser.Results:.Vitamin D levels were inversely correlated with plasma glucose levels(r=-0.38;p<0.01) with an Odd Ratio of 3.59(95%confidence interval 1.29 to 8.70).Fasting plasma glucose was significantly higher in VDD patientsas compared to patients withnormal...
ASSOCIATION OF VITAMIN D WITH TYPE 2 DIABETES MELLITUS IN KARACHI, PAKISTAN
Hypovitaminosis D has become a pandemic in the world populations and is believed to be related with the diabetes mellitus (DM). The aim of study was to assess the status of vitamin D along with other parameters in type 2 diabetic patients. Vitamin D (VD), calcium (Ca), phosphorous (Ph), random blood glucose (RBS) and HbA1c levels were assessed in 192 diabetic subjects. Hypovitaminosis D was prevalent in diabetic patients while, Ca and Ph levels were found in normal physiological range. RBS and HbA1c showed negative association with VD levels in vitamin D deficient and diabetic patients with good glycemic control.