Reinstatement of orienting behavior by d-amphetamine in rats with superior colliculus lesions (original) (raw)

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Orienting behavior by rats with visual cortical and subcortical lesions Cover Page

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Visual orientation in the rat: a dissociation of deficits following cortical and collicular lesions Cover Page

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The effects of lesions of the superior colliculus on locomotor orientation and the orienting reflex in the rat Cover Page

Chronic amphetamine enhances visual input to and suppresses visual output from the superior colliculus in withdrawal

Neuropharmacology, 2018

Heightened distractibility is a core symptom of Attention Deficit Hyperactivity Disorder (ADHD). Effective treatment is normally with chronic orally administered psychostimulants including amphetamine. Treatment prevents worsening of symptoms but the site of therapeutic processes, and their nature, is unknown. Mounting evidence suggests that the superior colliculus (SC) is a key substrate in distractibility and a therapeutic target, so we assessed whether therapeutically-relevant changes are induced in this structure by chronic oral amphetamine. We hypothesized that amphetamine would alter visual responses and morphological measures. Six-week old healthy male rats were treated with oral amphetamine (2, 5 or 10 mg/kg) or a vehicle for one month after which local field potential and multiunit recordings were made from the superficial layers of the SC in response to whole-field light flashes in withdrawal. Rapid Golgi staining was also used to assess dendritic spines, and synaptophysin...

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Chronic amphetamine enhances visual input to and suppresses visual output from the superior colliculus in withdrawal Cover Page

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The anatomical substrate of the turning behaviour seen after lesions in the nigrostriatal dopamine system Cover Page

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Response of rats with bilateral superior collicular lesions to change in the ambient visual environment Cover Page

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Disinhibition of the superior colliculus restores orienting to visual stimuli in the hemianopic field of the cat Cover Page

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Relation of contraversive turning to unilateral release of dopamine from the nigrostriatal pathway in rats Cover Page

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The relationship between lesion site, dopamine neurons, and turning behavior in the rat Cover Page

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The rotational behavior model: asymmetry in the effects of unilateral 6-OHDA lesions of the substantia nigra in rats Cover Page