Open label clinical trial to study adverse effects and tolerance to dry powder of the aerial part of andrographis paniculata in patients type 2 with diabetes mellitus (original) (raw)
Related papers
2011
Adverse effects and tolerance to dry powder of aerial part of Andrographis paniculata (Burm.f.) Nees were studied in 20 patients with type 2 diabetes mellitus for a period of 12 weeks. Patients were given powdered A. paniculata starting with 600 mg daily, gradually increasing to a maximum of 1.8 gm daily. Parameters monitored included body weight, blood pressure, liver function tests, renal function tests, cardiac enzymes, haemogram, serum electrolytes, fasting blood glucose, HbA1c, blood cholesterol, serum triglycerides and blood hormone levels (triiodotyronine, thyroxine, thyrotropin, insulin, fasting cortisol). None of the above mentioned parameters showed significant change during the study period except for a fall in HbA1c by 5.46%(p<0.01) and fasting S. insulin by 20.93%(p<0.003). In conclusion, A. paniculata powder did not induced significant adverse events based on parameters observed in our study but significantly lowered HbA1c and fasting serum insulin in patients wi...
International Journal of Diabetes in Developing Countries, 2006
The objective of this study was to evaluate the effect of commercially prepared spray-dried ethanolic extract ol Andrographis paniculafa (AP) on streptozotocin (STZ)-induced diabetic female rats. M ETHODOLOGY: Rats with regular estrous cycle (EC) prior to STZ induction were randomly divided into five groups. The normal (nondiabetic) and diabetic controlgroups were given vehicle [0.2 ml of 2o/o carboxyl methyl cellulose (CMC) by gavagingl daily for 6 weeks. Other diabetic groups were treated with 50, 100 and 200 mg/kg/day of AP extracts respectively. The rats' body weight (BW), fasting blood glucose and insulin level were measured; and daily, EC evaluation was perfo;.ry1e.d1 throughout the 6-week study period. At the end.olthe experiment, rats were sacrificed and their P4fprpases were removed for histological examination."RESU LTS':, The survival rates and estrous cycle,'$f''AP-treatbd diabetic animals were found to be improved compared to nontreated animals. No signifiognt difference in Diabetes mellitus (DM) i; a chronic disease with complex underlying etiologies. It was characterized by hyperglycemia and other metabolic abnorrnalities due to glucose intolerance.li2l The'ri{i'cidence of diabetes mellitus is on the rise Woildwid6r*Based on the World Health' Organization IWHO; report, the number of diabetic patients is expected tb increase from177 million in year 2000'to'366 mil.iibn or*more by the year 2030.t31 Herbal riie'dicine has been, andrwill be, used as antidiabetic. lherapy 4lone and al.pllg with insulin and other synthetic .,'oral !r pd$lycerriic"agents' The use of synthetic agents, on the other hand, has shown several undesirable side effectS and has failed to correct the fundamental biochemicil lesion and diabetic complications.la'sl This"ffi increased the use of alternative medicine to t=1$t'bV. The consrrmption of botanicals has been :,'iurtreasing and has continued to be an important area 'of active research woddwide. The herbal medicines are
International Journal of Public Health Science (IJPHS)
Diabetes mellitus (DM) is ricing nowadays. DM is a metabolic deasease characterized by increasing of glucose blood level for prolonged time. Patient with DM must take medicine for lowering glucose levels in whole life. Synthetic anti-diabetic agent is commonly used and significantly able to maintain the glucose blood levels. However, many side effects will occur during the treatment. Further, people is trying to find an alternative medicine for DM treatment. This paper will discuss about an alternative medicine for anti-diabetic agent that is called Andrographis paniculata (Burm. f.) Nees based in-vivo study. Search data obtained from PubMed, PMC (PubMed Central), International Food and Research Journal, and Google search engine. Inclution and exclution criteria were used for selection of journals. Inclution criteria were taken is in-vivo study of Andrographis paniculata as anti-diabetic, published in 2000-2014, and free full text journal or PubReader (full text journal in PubMed Ce...
international food research journal, 2014
Excessive food consumption regarding to high calorie, obesity, cardiovascular disease, stress, and lack of exercise are risk factors for diabetes mellitus (DM). One alternative therapeutic approach in DM patients is traditional use of herbal medicines such as Andrographis paniculata herbs. The aim of the study was to evaluate the antidiabetic effect of a combination of n-hexane insoluble fraction of A. paniculata herb (HIFA) with other traditional medicines i.e. curcuminoids fraction of Curcuma xanthorrhiza rhizome (CFC) or ethyl acetate soluble fraction of propolis (ESP) in high-fructose-fat-fed rats, a model of type 2 diabetes mellitus (DM) rats. These effects were compared to that of the single treatment of HIFA. The DM rats were induced by high-fructose-fat diet containing 36% fructose, 15% lard, and 5% egg yolks in 0.36 g/200 gb.wt for 60 days. The drugs were administered for 10 days, and the blood glucose levels were determined with an enzymatic colorimetric method (GOD-PAP). ...
In vitro and in vivo antidiabetic effect of Andrographis
Wt.Ic leaf extracts Andrographis lineata and Andrographis serphyllifolia are endemic potential medicinal plants of South India. The leaves of both the herbs have been used as ancient folklore medicine for curing diabetes, snakebite, inflammation and cancer. The present investigation deals with the study of in vitro and in vivo antidiabetic effect of the ethanolic leaf extract of A. lineata (EtALL) and ethanolic leaf extract of A. serphyllifolia (EtASL). Qualitative analysis of phytochemicals revealed the presence of alkaloids, tannins, terpenoids, steroids, flavanoids and polyphenol compounds, absence of saponins and steroids in both the extracts. The α-glucosidase inhibition results of EtALL (IC 50 value 10.12 µg/ml) and EtASL (IC 50 value 11.39 µg/ml) exhibited stronger inhibitory activity for α-glucosidase which was comparable with Acarbose. The 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay of the EtALL and EtASL extracts in 3T3-L1cell line confirmed that there was no toxicity effect for both the extracts from 6.5 to 50 µg/ml concentrations. The glucose uptake rate in 3T3-L1 cells revealed the fact that both the extracts showed increase in glucose uptake rate in dose dependent manner comparable to insulin. Further these extracts were evaluated in the in vivo model to prove the traditional claim of usage pertaining to antidiabetic property. The acute toxicity studies showed that there was no death or lethal effect observed in toxicity study. The acute treatment of fasting blood sugar and oral glucose tolerance test of EtALL and EtASL extract (400 mg/kg b.w.) treated normoglycemic rats showed hypoglycemic effect. When the streptozotocin induced diabetic rats was administered with EtALL and EtASL 400 mg/kg b.w. in chronic model (28 days) there was a significant reduction in plasma glucose, plasma insulin level, total cholesterol, low density lipoprotein (LDL)-C triglyceride, glucose-6phosphatase and fructose -1, 6-bisphosphatase levels. Glycogen content (liver and muscle), high density lipoprotein (HDL) cholesterol, hexokinase, was significantly increased compared with the diabetic control rats in both the extracts treated rats. The above findings showed the significant antidiabetic potential of the extracts in ameliorating the diabetic condition in the diabetic treated rats. Further studies are in progress to identify the active principle's possible for the antidiabetic effect in EtALL and EtASL extracts.
Metabolic effects of ten daily doses of standardized extract of Andrographis paniculata leaves (AP) rich in andrographolide were evaluated in a rat model of type-2 diabetes and in diet induced obese rats. AP was administered per-orally as suspension in 0.3% carboxymethylcellulose at doses of 50, 100 and 200 mg/kg/day for 10 consecutive days. Blood glucose, insulin and lipid profile of rats were measured by using enzyme kits. In addition, effects of such treatments on anti-oxidant enzymes activity and histopathological changes in various organs of diabetic rats were assessed. AP treatments reversed body weight losses and increased plasma insulin level in diabetic rats. The anti-oxidant enzymes activity became normal and histopathological changes observed in pancreas, liver, kidney and spleen of diabetic animals were less severe in extract treated groups. On the other hand, hyperinsulinemia and increased body weight gains observed in high fat or fructose fed rats were less severe in the extract treated groups. These observations revealed therapeutic potentials of the extract for treatments of diabesity associated metabolic disorders, and suggest that the effects of the extract on insulin homeostasis depend on the metabolic status of animals. Activation of cytoprotective mechanisms could be involved in its mode of action.
BioChem, 2021
Background: Diabetes is associated with chronic hyperglycaemia, long-term damage, dysfunction, and organ failure. This study aims to evaluate the antidiabetic activity of the twigs of Andrographis paniculata and its toxicological markers on Streptozotocin (STZ)-induced diabetic Albino rats. Methods: A total of thirty rats were randomly divided into five groups of six animals each. Non-diabetic animals were treated with distilled water as non-diabetic sham control group 1, while diabetic animals (group 2, 3, 4 and 5) were treated with 60 mg/kg bw STZ intravenous (iv) and 100 mg/kg body weight (bwt) of metformin orally for group 2, distilled water for group 3, and 250 and 500 mg/kg bwt of Andrograhis paniculata (A. paniculata) for groups 4 and 5, respectively. The animals were dosed for 28 days, after which they were sacrificed. Liver and kidney function tests as well as livid profile tests were used as the biomarkers of toxicological assessment. Fasting blood glucose was carried out ...
Eureka Herba Indonesia
Diabetes mellitus (DM) is a disease characterized by an increase in blood glucose levels caused by insulin deficiency, either absolute or relative. The α-glucosidase enzyme functions to accelerate the absorption of glucose by the small intestine by catalyzing the hydrolytic cleavage of oligosaccharides into monosaccharides. This study aims to explore the potential of AP extract in regulating blood sugar levels through inhibition of α-glucosidase activity in the intestine. This study is an in vivo experimental study. A total of 30 \ rats were divided into a control group and treated with Andrographis paniculata. Examination of blood sugar levels was carried out by spectrophotometry and examination of alpha-glucosidase enzymes by ELISA. Data analysis was performed using SPSS software with univariate and bivariate analysis. Andrographis paniculata extract was able to reduce blood sugar levels and was able to decrease the activity of the alpha-glucosidase enzyme as the dose increased. A...
Advances in Pharmacological and Pharmaceutical Sciences
Introduction. Researchers usually use herbal combinations to explore and develop traditional medicine to obtain additional benefits in the treatment of diseases, including diabetes. This study aims to evaluate the hypoglycemic effect of the combination of Andrographis paniculata (Burm. f.) Wall ex Nees and Caesalpinia sappan Linn extract (APCSE) on diabetes-induced rats. There has not been sufficient research on this combination; however, single extract studies of these plants have been widely conducted. Materials and Methods. Male Sprague Dawley rats (160–200 g) were induced by injecting a low dose of streptozotocin (35 mg/kg BW) twice and fed with a high-fat diet containing 25% fat, whereas control animals received only standard feed. Rats were treated with APCSE at doses of 100 mg and 200 mg/kg BW for seven days and compared to the APE and CSE groups treated with the extract at 100 mg, respectively. For the control group, rats were treated with metformin with a dose of 250 mg/kg....