Solitary Fibrous Tumor: A Retrospective Study on Histopathologic Features and Immunohistochemistry Staining at Cipto Mangunkusumo Hospital (original) (raw)
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Malignant solitary fibrous tumor: cytopathologic findings and differential diagnosis
Cancer cytopathology, 2010
Malignant solitary fibrous tumors (SFTs) are extremely uncommon and poorly understood mesenchymal neoplasms. There are only rare published accounts of the cytopathologic features of these tumors, prompting the current study. All cases of malignant SFT with preoperative fine-needle aspirations (FNAs) from 1999 to 2008 were retrieved from the archives of 3 large teaching hospitals. FNA smears and cell block material including immunoperoxidase stains were reviewed, and the cytologic characteristics were described. Thirteen cases of malignant SFT were identified in 11 patients. Mean age was 58 years, with a men:women ratio of 1:2.6. The tumors were generally large, with a mean size of 13.4 cm. Cytomorphologic features included mostly hypercellular smears with tissue fragments of monotonous, plump spindled cells with blunt-ended and indented nuclei and fragile, wispy cytoplasm. Also seen were bare nuclei, occasional mitoses, and rare necrosis. Some cases showed a predominance of epitheli...
Cytological Findings and Differential Diagnosis of Malignant Solitary Fibrous Tumors: A Case Report
2020
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms. These tumors were first described in 1931 by Klemperer and Rabin. Although SFTs are usually located in the thoracic cavity and pleura, they have been reported in numerous other extrathoracic sites. Nearly 85 to 90% of SFTs are benign. With the increasing use of fine needle aspiration (FNA) cytology in diagnosis, which is a less invasive technique than biopsy, we encounter with cytological smears of these tumors more frequently. Herein, we report a rare case of malignant SFT with relevant cytological findings and differential diagnosis in the light of literature data. 66-year-old male patient was admitted to the gastroenterology outpatient clinic in our center with dyspnea and feeling of abdominal fullness in right upper quadrant. We performed FNA biopsy from the heterogeneous lesion located in the inferior surface of the liver (25x20 cm in size) using 22-gauge needle under the guidance of endoscopic ultrasonography (EUS)...
Diagnostic Pathology, 2021
Background Solitary Fibrous Tumor (SFT) is a distinct soft tissue neoplasm associated with NAB2-STAT6 gene fusion. It can involve a number of anatomic sites and exhibits a wide spectrum of histological features. Main body Apart from diversity in morphological features seen even in conventional SFT, two histologic variants (fat-forming and giant cell-rich) are also recognized. In addition, a malignant form and dedifferentiation are well recognized. Owing to diverse histological features and involvement of diverse anatomic locations, SFT can mimic other soft tissue neoplasms of different lineages including schwannoma, spindle cell lipoma, dermatofibrosarcoma protuberans, liposarcoma, gastrointestinal stromal tumor (GIST), malignant peripheral nerve sheath tumor (MPNST), and synovial sarcoma. SFT is classified as an intermediate (rarely metastasizing) tumor according to World Health Organization Classification of Tumors of Soft tissue and Bone, 5th edition. The management and prognosis...
Healthmed
The solitary fibrous tumors (STF) are mesen-himal neoplasm. In 2002, WHO classified STF in two groups: benign and malignant. Patohistologi-cal classification is based on three characteristics: more then 4 mitosis in 10 high power fields, pleo-morfismus, and necrosis are malignant signs. Sur-gical en block resection is basic treatment tech-nique. Adjuvant treatment in malignant form, by literature, is not very effective. Surgical treatment is first line of treatment even in case of recidive. Neo-adjuvant treatment suggested for mali-gnant form of this tumor is limited because it is impossible preoperatively to determine definitive patohistological diagnosis. It is due to insufficient amount of tissue example, provided by punction biopsy under CT. In this paper we will show STF operated at 1997 year, and recidive after nine years which was successfully extracted. Sažetak Solitarni fibrozni tumor (SFT) je neoplazma mezenhimalnog porijekla koja se na osnovu WHO (World Health organizatio...
Solitary fibrous tumor ¿ clinicopathologic, immunohistochemical and molecular analysis of 28 cases
Diagnostic pathology, 2014
BackgroundSolitary fibrous tumor is a mesenchymal tumor of fibroblastic type, which can affect any region of the body. Recently, a recurrent gene fusion NAB2-STAT6 has been identified as molecular hallmark. The NAB2-STAT6 fusion leads to EGR1 activation and transcriptional deregulation of EGR1-dependent target genes and is a driving event in initiation of SFT. In this study, we report the clinicopathologic and RT-PCR findings and evaluated expression of STAT6 and EGR1 protein in a cohort of 28 SFTs.Methods28 patients with a median age of 54 years were included with SFTs originating at different sites, most occurring in the lung and pleura (9, 32%), 5 in soft tissues of the lower extremities (18%) and 5 in the head and neck (18%). For detection of the NAB2-STAT6 fusion gene, RT-PCR was performed using RNA extracted from formalin-fixed and paraffin-embedded tissues. Immunohistochemistry was performed on all cases with antibodies against STAT6 and EGR1.ResultsAll patients were treated ...
Malignant solitary fibrous tumor in the extremity: Cytopathologic findings
Journal of Cytology, 2012
Malignant solitary fibrous tumor (SFT) is an extremely rare neoplasm. There are only rare published accounts of the cytopathologic features of this tumor. We report a case of a 59-year-old woman presented with a 10-year history of a right thigh mass. A preoperative fine needle aspiration (FNA) was performed. Smears were hypercellular, with cohesive and crowded tissue fragments, haphazard cell arrangements and many single cells. The tumor cells were polymorphous, plump spindled or round with often indented or bare nuclei. A differential diagnosis of low grade sarcoma was favored. The diagnosis of malignant SFT is extremely difficult on FNA and must be included in the differential diagnosis of spindle cell neoplasms.
Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumor
Cancer Genetics and Cytogenetics, 2008
Solitary fibrous tumor is a mesenchymal tumor that was initially described as a pleural-based lesion, but later was discovered in many other locations. The light microscopic appearance of solitary fibrous tumor may overlap with other diagnostic entities; however, consistent tumor cell CD34 immunoreactivity is useful in establishing the diagnosis. Limited data suggest that solitary fibrous tumors are karyotypically diverse; a common or characteristic anomaly has not yet emerged for this entity. In this report, cytogenetic analysis of two solitary fibrous tumors, one peritoneal and the other arising in the liver, revealed predominantly structural abnormalities in the former and numerical imbalances in the latter. Clonal karyotypic abnormalities were lacking in three additional solitary fibrous tumors.
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model
Modern Pathology, 2012
Solitary fibrous tumor represents a spectrum of mesenchymal tumors, encompassing tumors previously termed hemangiopericytoma, which are classified as having intermediate biological potential (rarely metastasizing) in the 2002 World Health Organization classification scheme. Few series have reported on clinicopathological predictors with outcome data and formal statistical analysis in a large series of primary tumors as a single unified entity. Institutional pathology records were reviewed to identify primary solitary fibrous tumor cases, and histological sections and clinical records reviewed for canonical prognostic indicators, including patient age, tumor size, mitotic index, tumor cellularity, nuclear pleomorphism, and tumor necrosis. Patients (n ¼ 103) with resected primary solitary fibrous tumor were identified (excluding meningeal tumors). The most common sites of occurrence were abdomen and pleura; these tumors were larger than those occurring in the extremities, head and neck or trunk, but did not demonstrate significant outcome differences. Overall 5-and 10-year metastasis-free rates were 74 and 55%, respectively, while 5-and 10-year disease-specific survival rates were 89 and 73%. Patient age, tumor size, and mitotic index predicted both time to metastasis and disease-specific mortality, while necrosis predicted metastasis only. A risk stratification model based on age, size, and mitotic index clearly delineated patients at high risk for poor outcomes. While small tumors with low mitotic rates are highly unlikely to metastasize, large tumors Z15 cm, which occur in patients Z55 years, with mitotic figures Z4/10 high-power fields require close follow-up and have a high risk of both metastasis and death.
International Journal of Molecular Sciences
Although solitary fibrous tumors (SFTs) have an unpredictable evolution, some specific clinicopathologic factors have been associated with the final outcome. We retrieved clinical, pathological and molecular data of 97 patients with a histological diagnosis of SFT and Signal transducer and activator of transcription 6 (STAT6) positivity. We retrospectively studied the pathological factors predictive of recurrence/metastasis and compared them with the clinical outcome. A wide immunohistochemical study and molecular analysis to detect NAB2/STAT6 gene fusion, tumor protein-53 (TP53) and/or (telomerase reverse transcriptase) TERT promotor mutation were performed. The risk of metastasis was calculated using the Demicco risk stratification system (RSS). The results were combined and examined to assess the accuracy of risk stratification and classification. The most common location was in non-extremities; 66% were located in soft tissue or subcutaneous areas and 92.8% in deep locations. On...
Malignant Solitary Fibrous Tumor : A Report of Two Cases
2018
Case Report 1: A 39-year-old woman presented with a tumefaction of the left thigh, measuring 13 centimeters in diameter. A chest, abdomen and pelvis computed tomography (C.A.P. CT) showed a mass measuring 20 cm, located in the left psoas muscle, with extension to the pelvis, and pulmonary metastases. Histopathological analysis of the specimen was consistent with malignant solitary fibrous tumor. Case Report 2: A 80-year-old man presented with a mass of the right nasal cavity. Cranio-facial MRI showed the presence of a tumor of the right nasal cavity with intracranial extension. Histopathological analysis of the specimen was consistent with malignant solitary fibrous tumor. The solitary fibrous tumor is a rare mesenchymal tumor. It is preferentially located at pleura. Extra-thoracic localization is rare. In soft tissue, solitary fibrous tumor accounts for approximately 0.6% of tumors. The sinonasal localization is very rare. Histologically, the tumor is made of a dense proliferation ...