Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumor (original) (raw)
Related papers
Cytological Findings and Differential Diagnosis of Malignant Solitary Fibrous Tumors: A Case Report
2020
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms. These tumors were first described in 1931 by Klemperer and Rabin. Although SFTs are usually located in the thoracic cavity and pleura, they have been reported in numerous other extrathoracic sites. Nearly 85 to 90% of SFTs are benign. With the increasing use of fine needle aspiration (FNA) cytology in diagnosis, which is a less invasive technique than biopsy, we encounter with cytological smears of these tumors more frequently. Herein, we report a rare case of malignant SFT with relevant cytological findings and differential diagnosis in the light of literature data. 66-year-old male patient was admitted to the gastroenterology outpatient clinic in our center with dyspnea and feeling of abdominal fullness in right upper quadrant. We performed FNA biopsy from the heterogeneous lesion located in the inferior surface of the liver (25x20 cm in size) using 22-gauge needle under the guidance of endoscopic ultrasonography (EUS)...
Malignant solitary fibrous tumor: cytopathologic findings and differential diagnosis
Cancer cytopathology, 2010
Malignant solitary fibrous tumors (SFTs) are extremely uncommon and poorly understood mesenchymal neoplasms. There are only rare published accounts of the cytopathologic features of these tumors, prompting the current study. All cases of malignant SFT with preoperative fine-needle aspirations (FNAs) from 1999 to 2008 were retrieved from the archives of 3 large teaching hospitals. FNA smears and cell block material including immunoperoxidase stains were reviewed, and the cytologic characteristics were described. Thirteen cases of malignant SFT were identified in 11 patients. Mean age was 58 years, with a men:women ratio of 1:2.6. The tumors were generally large, with a mean size of 13.4 cm. Cytomorphologic features included mostly hypercellular smears with tissue fragments of monotonous, plump spindled cells with blunt-ended and indented nuclei and fragile, wispy cytoplasm. Also seen were bare nuclei, occasional mitoses, and rare necrosis. Some cases showed a predominance of epitheli...
Malignant metastasizing solitary fibrous tumors of the liver: a report of three cases
Polish Journal of Pathology, 2015
Solitary fibrous tumors are rare neoplasms of mesenchymal origin that have been reported in various other extrathoracic sites, including the liver. We present a case series of three malignant solitary fibrous tumors of the liver, occurring in two women 74 and 80 years old and one 65-year-old man. No clinical features were predictive of malignancy except the large sizes and synchronous presence of lung metastases in two of the three cases. Histological examinations revealed the presence of high pleomorphic cellularity with nuclear atypia, necrosis and high mitotic ratios. All patients died of disease progression.
Solitary fibrous tumor of the liver - An unusual entity: A case report and review of literature
Annals of hepato-biliary-pancreatic surgery, 2018
Solitary fibrous tumor (SFT) of the liver is a rare entity and its presentation is usually delayed till they grow to a substantial size. Clinico-radiological features are non-specific, contributing to increase in the diagnostic dilemma. Definitive diagnosis of SFT is usually made based on the histological features and immunohistochemistry data of the resected specimen. In this case report, we describe the case of an elderly male who presented with a large mass in the left lobe of the liver with normal level of tumor markers and atypical radiological findings. The patient successfully underwent resection of the tumor and the diagnosis was confirmed on histopathology.
Hepatic solitary fibrous tumor: Report of a rare case
Indian Journal of Pathology and Microbiology, 2012
Solitary fi brous tumor (SFT) of the liver is an extremely rare neoplasm of mesenchymal origin. In the English literature, less than 40 cases of SFTs of the liver have been reported. The present case concerns a 34-year-old female who presented to us with complaint of dyspepsia. On examination, there was hepatomegaly. On ultrasound examination, an SOL in the liver was detected. Large tumor measuring 14.5 × 10 × 8 cm was resected. Microscopic evaluation of the tumor showed a well-circumscribed, low to moderately cellular tumor demonstrating spindle-and fi broblast-like cells within the collagenous stroma. Immunohistochemistry revealed diffuse strong cytoplasmic immunopositivity of CD34, Bcl2, and vimentin. A diagnosis of a benign SFT was given. The patient remained well 4 years after surgery. SFT is a rare mesenchymal neoplasm that occasionally involves the liver in adult patients. Most SFTs are benign, but some may have malignant histological features. With less than 40 reported cases in the literature, little can be said regarding its natural history or the benefi ts of adjuvant radio chemotherapy. Complete surgical resection remains the cornerstone of its treatment.
eJurnal kedokteran Indonesia, 2018
Solitary fibrous tumor (SFT), is a rare mesenchymal spindle cell tumor and its biological behavior is hard to predict. There is no characteristic clinical manifestation and morphologic features showed broad spectrum, so often diagnosed as other spindle cell mesenchymal tumor, benign or malignant. In most cases, immunohistochemistry staining (IHC) is needed to diagnose SFT. The aim of this retrospective study is to see demographic data, histopathological features and the importance of IHC staining diagnosis of SFT.
Solitary Fibrous Tumor of the Liver : A Case Report
2001
Hepatic solitary fibrous tumor (SFT) is a rare tumor originating from the mesenchyme. Here we report a new case of SFT in the liver and review the clinical presentation, radiological and operative findings, diagnosis, treatment, and outcome. The patient was a 59-year-old man who presented with progressive fatigue for 3 months and an abdominal mass for 3 days. On laboratory tests, no abnormality was detected except that abdominal ultrasonography revealed a 9.0 × 6.2 cm hypoechogenic mass in the left lobe of the liver. A computed tomographic scan confirmed a hypodense lesion in the left lobe of the liver. The patient underwent left hepatectomy. SFT was diagnosed on the basis of histopathological findings. The patient was free from all symptoms and had no signs of local recurrence after 24 months' follow up.
Solitary fibrous tumor ¿ clinicopathologic, immunohistochemical and molecular analysis of 28 cases
Diagnostic pathology, 2014
BackgroundSolitary fibrous tumor is a mesenchymal tumor of fibroblastic type, which can affect any region of the body. Recently, a recurrent gene fusion NAB2-STAT6 has been identified as molecular hallmark. The NAB2-STAT6 fusion leads to EGR1 activation and transcriptional deregulation of EGR1-dependent target genes and is a driving event in initiation of SFT. In this study, we report the clinicopathologic and RT-PCR findings and evaluated expression of STAT6 and EGR1 protein in a cohort of 28 SFTs.Methods28 patients with a median age of 54 years were included with SFTs originating at different sites, most occurring in the lung and pleura (9, 32%), 5 in soft tissues of the lower extremities (18%) and 5 in the head and neck (18%). For detection of the NAB2-STAT6 fusion gene, RT-PCR was performed using RNA extracted from formalin-fixed and paraffin-embedded tissues. Immunohistochemistry was performed on all cases with antibodies against STAT6 and EGR1.ResultsAll patients were treated ...
Malignant Solitary Fibrous Tumor : A Report of Two Cases
2018
Case Report 1: A 39-year-old woman presented with a tumefaction of the left thigh, measuring 13 centimeters in diameter. A chest, abdomen and pelvis computed tomography (C.A.P. CT) showed a mass measuring 20 cm, located in the left psoas muscle, with extension to the pelvis, and pulmonary metastases. Histopathological analysis of the specimen was consistent with malignant solitary fibrous tumor. Case Report 2: A 80-year-old man presented with a mass of the right nasal cavity. Cranio-facial MRI showed the presence of a tumor of the right nasal cavity with intracranial extension. Histopathological analysis of the specimen was consistent with malignant solitary fibrous tumor. The solitary fibrous tumor is a rare mesenchymal tumor. It is preferentially located at pleura. Extra-thoracic localization is rare. In soft tissue, solitary fibrous tumor accounts for approximately 0.6% of tumors. The sinonasal localization is very rare. Histologically, the tumor is made of a dense proliferation ...
Solitary fibrous tumour arising at unusual sites: analysis of a series
Histopathology, 1991
Solitary fibrous tumours (‘pleural fibromas’) are well-recognized in the pleura, but their rare occurrence at other sites has only become appreciated in recent years, as a consequence of which extrapleural examples often go unrecognized or misdiagnosed. Eight cases (three peritoneal, two retroperitoneal. two intrapulmonary and one mediastinal) are presented herein. All but one presented in adulthood, and three were asymptomatic chance findings. Size ranged from 0.8 to 26 cm in maximum diameter. To date, none has behaved in an aggressive fashion. Histologically, these lesions are entirely comparable to their pleural counterparts, and accurate diagnosis is largely dependent on appreciation of their potential extrapleural location. Immunohistochemistry in seven cases favoured myofibroblastic fibroblastic differentiation, in keeping with the putative submesothelial origin of these lesions.