Diabetic Predecessors: A factor leading to diabetes in successors (original) (raw)
Related papers
Original Article OPEN ACCESS Familial early onset of type-2 diabetes mellitus and its complications
Background: Globally, the prevalence of chronic, non-communicable diseases is increasing at an alarming rate. Furthermore, approximately 197 million people worldwide have impaired glucose tolerance. Consequently, diabetes is rapidly emerging as a global health problem that threatens to assume a pandemic level by 2030. In Indian population, genetic predisposition to trigger diabetes at an early age as compared to western counterpart has been focused very much. Aim: To gain further insight into the positive correlation between the diabetes and family history was the objective of this study. Materials and Methods: Patients attending the Diabetes were recruited, diagnosed and analyzed as per WHO criteria. Results: The prevalence of diabetes was higher among patients with diabetic mother (25.6%) compared to patients with diabetic father (21.2%) and there was early onset of type -2 diabetes among patients having both parents with diabetic when compared to other patients. Conclusion: Based on the present observation, it would be appropriate to emphasize again that a strong family history for diabetes, would signal at an early age, the onset of diabetes perhaps with its complications.
Epidemiologic study of familial Type 2 diabetes in Tehran
Journal of advanced pharmaceutical technology & research, 2018
Type 2 diabetes is the most common cause of hyperglycemia. It has different prevalence in various populations. It has been found out that type 2 diabetes is a genetic disorder; however, its inheritance and its type have not been well defined. In studying the genes involved in the development of diabetes, several genes have been introduced as candidates; however, the gene or genes involved in diabetes cannot be identified yet. As family diabetes has not been studied in Iran so far, this study was conducted on a population aged over 20 years in east of Tehran. In a population of 14,687 people living in east of Tehran, 180 families with type 2 diabetes were identified. In this research, 802 subjects were female and 792 were male. After oral glucose tolerance test, 40.7% of females and 32.3% of males had diabetes. The incidence of diabetes in females was significantly higher than that in males (P < 0.001). It was found that 656 diabetic patients had age over 20 years, which most of them had age between 41 and 70 years. The highest number of diabetic patients was in the age group of 51-60 years. The percentage of offspring and siblings involvement in this sample was 44% and 53%, respectively. The highest level of involvement among the first-degree family members belonged to sister-brother, followed by father-daughter. This study shows the relationship between family diabetes in Iranian families in a demographic study. By recognizing the family relations, effective measures can be taken to prevent this disease. In the case of type 2 diabetes development in one member of family, the incidence of diabetes in other family members would increase by up to 50%. Thus, screening is suggested for all type 2 diabetic family members continuously so that the disease to be immediately diagnosed and treated to prevent major complications of diabetes.
Hereditary Contribution Towards Development of Type 2 Diabetes Mellitus among Indian Population
Diabetes Research – Open Journal
Diabetes Mellitus Type II is becoming a major disorder. This study describes the inheritance of type 2 diabetes mellitus in families with diabetes. Methods The study was conducted in Manipur in two districts i.e., Imphal-east and Thoubal among Muslim families. These families were considered for the present study in which one or more family members had diabetes and were involved as active participants. Results On tracing the genealogies of each family, a higher percentage of the participants with diabetes inherited the disease from their fathers. Conclusions This finding would be helpful in future research by implementing among different communities.
Bratislava Medical Journal, 2012
Background and objectives: We designed this study to observe the DM prevalence, insulin resistance, beta cell reserve and the interaction of these parameters in the fi rst degree relatives of Type 2 diabetic patients in Turkish population. Methods: 125 subjects were included in the study. 25 subjects without the fi rst degree diabetic relatives were selected as the control group; they were matched by age, BMI, socio-economical, cultural and environmental factors. (OGTT), (IVGTT), (GST), and (ITT), were performed on all subjects and controls. Results: 12 (9.6 %) DM and 23 (18. 4 %) impaired glucose tolerance (IGT) cases of 125 subjects were diagnosed according to OGTT results. The mean BMI of diabetic subjects was signifi cantly higher than of controls and subjects with normal glucose tolerance (p<0.05). When compared to the control group, the mean AUCinsulin levels were signifi cantly lower in diabetic subjects (p<0.05). To observe the correlation between HOMAIR and KITT values, a statistically signifi cant correlation was found (p<0.05, r: 0.222). There was a defi ciency in the Cpeptide response to glucagon stimulation in diabetic relatives (p<0.05, F: 4.59 One Way ANOVA). Conclusion: We demonstrated that the fi rst degree relatives of Type 2 diabetic patients constitute a high risk group for DM, IGT and insulin resistance by using four different tests in Turkish population. The signifi cant fi nding(s) of the study: We demonstrated a high prevalence of glucose metabolism disorders in the relatives of type 2 diabetic patients. This study adds our knowledge; insulin resistance and decreased beta cell reserve occur before diabetes mellitus begin in relatives (Tab. 5, Ref. 42). Full Text in PDF www.elis.sk.
Clinical and Experimental Health Sciences, 2021
Objective: This study was conducted to evaluate the diabetes risk in first degree relatives of Type-2 diabetic patients who were not diagnosed with diabetes and test the validity of the Finnish Diabetes Risk Score (FINDRISK) in determining the risk of type-2 diabetes. Methods: First degree relatives of patients who were hospitalized in “İzmir Katip Çelebi University Atatürk Training and Research Hospital”, who were not diagnosed with diabetes before, were included in this cross-sectional study. The sample of the research consisted of 200 people determined by power analysis. Data were collected by “a structured question form” and the FINRISK scale. Participants’ height, weight, waist circumference were measured by the researcher, and venous fasting blood glucose (FBG) with Glycosylated Hemoglobin (HbA1c) were taken by the researcher. Results: The average age of the participants was 46.93 ± 14.83 (18-86). It was determined that the vast majority of the individuals participating in the...
International Research Journal of Pharmacy, 2015
There is a significant increase in the incidence and prevalence of Diabetes Mellitus (DM) worldwide and in the Kingdom of Saudi Arabia (KSA). Various studies have been shown the relevance of genetic factor in the onset of type-2 diabetes mellitus (T2DM). In this view the study has been conducted to find the correlation between family history and glycemic control among the T2DM patients in Aseer Diabetic Center (ADC), Abha KSA. This is a cross sectional retrospective study. A total of 343 patient's medical records were accessed to evaluate the role of family history in glycemic control. For the purpose of the study patients were randomly selected and divided into four groups (I-without family history; II-with first degree family history; III-with second degree family history and IV-with both first and second degree family history). The HbA1c value was considered as primary outcome measure in each group. In addition to this other factors such as age, duration of DM, BMI (Body Mass Index) were also studied. Among this study population, about 54.81 % of patients had positive 1 st degree family history. The mean age for patients without family history is 62.19 (± 9.29) yrs and 59.98 (± 10.39) for patients with family history, which shows that occurring of DM is early in positive family history groups. The HbA1c value in patients without family history and with family history in either sex is not significant (p < 0.39). In our study, HbA1c levels show no significant difference between patients with and without family history. In conclusion the family history plays no significant role in glycemic control in T2DM patients in ADC.
Strong family history predicts a younger age of onset for subjects diagnosed with type 2 diabetes
Diabetes, Obesity and Metabolism, 2004
Aims: Age of onset of type 2 diabetes is becoming earlier and with it there is an increase in the development of chronic complications. This study examined the relationship between the strength of family history of diabetes on (i) age of diabetes onset and (ii) prevalence of diabetic complications. Research design and methods: Data on family history of diabetes and age of diabetes onset were prospectively collected on 5193 subjects. Family members were deemed to include grandparents, parents, siblings, aunts/uncles and children. To adjust for family size and to assess effects of pathway to diagnosis, we also contacted a subset of 180 patients selected on the basis of the strength of family histories of diabetes. A full assessment for diabetic complications including retinopathy, neuropathy and renal and macrovascular status was performed for the total cohort. Results: The more cases of diabetes found in a family, the younger the age of onset of type 2 diabetes. This phenomenon does not appear to be due to patients with strong family history of diabetes being more concerned about the possibility of having diabetes. The effect of strong family history is also evident in many ethnic groups when examined individually, although they differ from each other in their characteristic age of onset of diabetes. Once adjusted for duration of diabetes, strength of family history does not appear to affect metabolic profiles or prevalence of chronic complications. Conclusions: There is a strong relationship between the number of affected family members with diabetes and age of developing diabetes. The genetic and environmental factors underlying this phenomenon remain to be elucidated. However, it may be one of the reasons explaining why type 2 diabetes is affecting younger people worldwide.
Lifestyle changes in descendants of parents with diabetes type 2
Revista Latino-Americana de Enfermagem, 2007
This study aimed to explore the disposition of diabetic parents&amp;amp;amp;#39; descendents in changing eating and physical activity patterns. It was based on the heritability concept and Prochaska&amp;amp;amp;#39;s Transtheoretical Model. This is a descriptive-correlational study; participants included 30 parents, randomly selected, and 60 children. 68% of the children was classified as obese, 42% with insulin resistance, and 15% with carbohydrate intolerance. None of the risk factors was associated with the stages of change. The heritability factor was 1.37%; more people younger than 40 and women report decreasing in the consumption of fat food (Xi(2)=6.04, p=.020; and 4.41, p=.040, respectively). These results suggest a high influence of environmental factors on the participants&amp;amp;amp;#39; unhealthy life styles.