Experimental and theoretical characterization of Dy-doped hydroxyapatites (original) (raw)
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Behavior of Doped Hydroxyapatites During the Heat Treatment
Revista de Chimie, 2018
The goal of this investigation is related to the development of nanostructured biomaterials based on hydroxyapatite (HAP) and multi-doped hydroxyapatites (HAPs), with essential physiological elements, like Mg, Zn, Sr, and Si, for bone repair and regeneration. Nano hydroxyapatites pastes and powders were obtained by wet chemical method using innovative nanotechnology and advanced processing of biomaterials at various temperatures to control the crystallite size and crystallinity degree. The prepared HAPs were analysed by various physical and chemical methods, like SEM, SEM-EDX, AFM, XRD, TG and DSC analysis. The results showed that these biomaterials both in pastes and in powders contained a unique phase, characterized by the HAP structure, which was substantially preserved even at 1000 oC, indicating a high thermal stability of these biomaterials. To enhance their usage, we have prepared HAP and multi-doped HAPs in the form of pastes with controlled humidity (moisture) and powders w...
Journal of the Australian Ceramic Society, 2020
Five samples of hydroxyapatite (HAp) doped with praseodymium (Pr) at various amounts (2, 4, 6, 8, and 10 at.%) were synthesized by using the wet chemical route. The effects of Pr doping on the structural and thermal properties, as well as on the in vitro performance of HAp, were investigated experimentally. The band structure and density of states (DOS) of HAp were studied theoretically. Incorporation of Pr into the crystal lattice of HAp was observed. A gradual increase in the crystallite size, lattice parameter a, and unit cell volume was found, and a gradual decrease in the crystallinity degree was seen. Pr content from 2 to 10 at.% did not affect the thermal stability of HAp. The theoretical results showed that the bandgap energy of HAp decreased steadily from 3.82 to 1.32 eV with the adding of Pr, and the DOS was also affected by the Pr content. The cell viability tests showed that among all the as-synthesized samples, the best biocompatible properties were found for the sample which was doped with 10 at.% Pr, and the amount of Pr affected significantly the cell viability property of HAp. Except for the sample having 6 at.% Pr, all the remaining samples appeared to be potentially good candidates for biomedical applications.
Nanobiomedicine, 2015
Morphology controlled hydroxyapatite (HAp) nanostructures play a vital role in biomedical engineering, tissue regenerative medicine, biosensors, chemotherapeutic applications, environmental remediation, etc. The present work investigates the influence of temperature, pH and time on the growth of HAp nanostructures using a simple, cost effective and surfactant free chemical approach. The obtained HAp nanostructures were systematically investigated by analytical techniques such as XRD, FESEM, EDX, FTIR and Raman spectroscopy. The XRD analysis showed that the hexagonal structure of the hydroxyapatite and average crystallite size was estimated from this analysis. The electron microscopic analysis confirmed the different morphologies obtained by varying the synthesis parameters such as temperature, pH and time. The elemental composition was determined through EDS analysis. FTIR and Raman spectroscopic analysis confirmed the presence of functional groups and the purity and crystallinity of the samples. The biocompatibility and adhesion nature of samples was examined with mouse preosteoblast cells. The obtained results demonstrated good biocompatibility and excellent focal adhesion.
A Crystal Chemistry of Hydroxyapatite : A Review
International Journal of Advanced Research, 2021
In chemistry of inorganic crystals, the octacalcium phosphate (OCP) is an apatite based crystals and having a hydrated layers which used in producing of needle or plate-shaped hydroxyapatite (HAP) nanocrystals. Although, the crystals is prepared by a dissolution precipitation reaction. These reaction led to a hexagonal HAP nanocrystals formation under hydrothermal condition from OCP at 180 for 3 hours with pH of solution adjusted to 5.5 and incorporating dicarboxylate e.g. succinate (OOC.(CH2)2.COO)2- ions having Ca/P molar ratio is expected to be 1.56±0.02, where the morphology of OCP are retained. During incorporating of succinate ions in OCP crystals, the hydrogen phosphate (HPO42-) ions in the hydrated layers of OCP are being substituted by succinate ions. Since the crystal system of HAP is hexagonal and its crystalline size in the longitudinal direction of various (a,b,c) axes depending on the thickness of the laminated plate-shaped HAP crystals. Here, their size as perpendicu...
Synthesis and characterization of undoped and doped hydroxyapatite materials
Ann, 2023
Hydroxyapatite (HAp) has received great attention in recent years due to the increasing demand for biomaterials. Its use as an orthopedic implant and filler is due to its unique bioactivity, biocompatibility, osteoconductivity, and crystal structure that closely matches the mineral fraction of natural bone [1]. Because chemically synthesized HAPs have structures similar to biological HAPs, natural HAPs are useful in other ways, such as stabilizing calcium-rich minerals in dependent osteoblasts. For dentin or implant applications. You can access resources. Bone permeability is responsible for its ability to closely conform to normal bone, and its ability to exchange with various ions gives it a degree of biocompatibility and natural bioactive properties.
Matéria (Rio de Janeiro)
In this work, a study of hydroxyapatite (HAp) powders obtained using both, porcine bones and chemical precursors was carried put. In the case of HAp obtained by means of porcine bones, physical processes as cooking, washing and milling were developed, for removing the organic material from the bones; after that, the powders were submitted to a thermal treatment at 800 °C, during 12 h. This procedure was carried out without adding chemical alkalines that are harmful for the environment and the human health. On the other hand, HAp powders were also synthetized using the chemical precipitation method widely reported, showing successful results. Moreover, both kind of powders were characterized using x ray diffraction, Fourier transformer infrared spectroscopy, scanning electron microscopy and energy dispersive spectroscopy. Furthermore, the bioactivity of the materials was determined using the simulated biological fluid (SBF) method. Results showed that the natural HAp exhibited better crystallographic properties. Moreover, according to these results, HAp obtained from porcine bones contains traces of elements as Na and Mg that are favorable for the bioactivity, according to the materials behavior when they are immersed in SBF.
Synthesis and characterization of undoped and doped hydroxyapatite material-
Ann, 2023
Hydroxyapatite (HAp) has received great attention in recent years due to the increasing demand for biomaterials. Its use as an orthopedic implant and filler is due to its unique bioactivity, biocompatibility, osteoconductivity, and crystal structure that closely matches the mineral fraction of natural bone [1]. Because chemically synthesized HAPs have structures similar to biological HAPs, natural HAPs are useful in other ways, such as stabilizing calcium-rich minerals in dependent osteoblasts. For dentin or implant applications. You can access resources. Bone permeability is responsible for its ability to closely conform to normal bone, and its ability to exchange with various ions gives it a degree of biocompatibility and natural bioactive properties
A comparative study of functionalized nano-hydroxyapatite
2015 E-Health and Bioengineering Conference (EHB), 2015
In an attempt to obtain appropriate components for complex transfection systems hydroxyapatite nanoparticles (nHAp) were synthesized by means of wet chemical precipitation method, under atmospheric pressure, in the absence or presence of different low-molecular or polymeric cationic dispersants, i.e. arginine, linear or branched polyethylenimine (LPEI, bPEI). The effect of added compounds' type and concentration on nHAp characteristics (surface chemistry, size, morphology, crystallinity, dispersibility) was comparatively studied. The chemical composition and surface modification of the synthesized nano-HAp was investigated using Fourier Transformed Infrared Spectroscopy (FTIR), Energy Dispersive X-Ray (EDX) analysis, Zeta potential measurements (DLS-dynamic light scattering) and UV-vis spectrophotometry. The crystal morphology and particle size were characterized by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-Ray Diffraction technique (XRD). The DNA binding ability of the functionalized nHAp was tested by agarose gel electrophoresis assay.
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A researcher needs to know all the chemical, physical, biological, structural, and mechanical characteristics of a biomedical material before using it in medical applications. The mineral hydroxyapatite (HAp, Ca10(PO4)6(OH)2) is an essential component of the calcium orthophosphate family. It possesses great dielectric and biological compatibility properties, diamagnetic properties, thermal stability, osteoconductivity, and bioactivity, which has a Ca:P molar ratio of 1.67. Since HAp has a chemical makeup that is very similar to that of natural bone and teeth, it has the potential to be utilized as a material for the implantation of implants in broken parts of the human skeletal system. Because of the increasing use of HAp in medicine, many methods for producing HAp nanoparticles have been discovered. The preparation conditions of synthesized HAp determine their physical and chemical characteristics, crystalline structure, and shape. This study gives a comprehensive information on the properties and production methods of the HAp in detail and unveile the structure and its properties in detail
Synthesis, structural properties and thermal stability of Mn-doped hydroxyapatite
2010
Hydroxyapatite (HA)-Ca 10 (PO 4) 6 (OH) 2 is a basic inorganic model component of hard biological tissues, such as bones and teeth. The significant property of HA is its ability to exchange Ca 2+ ions, which influences crystallinity, physico-chemical and biological properties of modified hydroxyapatite materials. In this work, FTIR, Raman spectroscopy, XRD, SEM and EDS techniques were used to determine thermal stability, chemical and phase composition of Mn containing hydroxyapatite (MnHA). Described methods confirmed thermal decomposition and phase transformation of MnHA to aTCP, bTCP and formation of Mn 3 O 4 depending on sintering temperature and manganese content. In vitro biological evaluation of Mn-modified HA ceramics was also performed using human osteoblast cells.