Dynamic action of the Sec machinery during initiation, protein translocation and termination (original) (raw)

Bacterial Sec Protein Transport is Rate-limited by Precursor Length: A Single Turnover Study

Fu-Cheng Liang

Biophysical Journal, 2009

Energy landscape steering in SecYEG mediates dynamic coupling in ATP driven protein translocation

Tara Sabir

The Bacterial ATPase SecA Functions as a Monomer in Protein Translocation

Dana Boyd

Journal of Biological Chemistry, 2005

Mapping polypeptide interactions of the SecA ATPase during translocation

Proceedings of the National Academy of Sciences, 2009

Bacterial protein translocation requires only one copy of the SecY complex in vivo

Journal of Cell Biology, 2012

A molecular switch in SecA protein couples ATP hydrolysis to protein translocation

Andresa Nastacia

Molecular …, 1999

Protein Translocation Is Mediated by Oligomers of the SecY Complex with One SecY Copy Forming the Channel

Cell, 2007

Energy transduction in protein transport and the ATP hydrolytic cycle of SecA

Ian Collinson

Proceedings of the National Academy of Sciences, 2009

Translocation of proteins through the Sec61 and SecYEG channels

Reid Gilmore, Elisabet Mandon

Current Opinion in Cell Biology, 2009

Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

Roman Tuma

eLife, 2016

Structural determinants of protein translocation in bacteria: conformational flexibility of SecA IRA1 loop region

Raffaele Ragone, Pasquale Palladino

Journal of Peptide Science, 2011

Atomic Model of the E.coli Membrane-bound Protein Translocation Complex SecYEG

Ian Collinson

Journal of Molecular Biology, 2005

Structure of a complex of the ATPase SecA and the protein-translocation channel

Nature, 2008

Topology of the Integral Membrane Form of Escherichia coli SecA Protein Reveals Multiple Periplasmically Exposed Regions and Modulation by ATP Binding

Journal of Biological Chemistry, 1997

Alignment of the protein substrate hairpin along the SecA two-helix finger primes protein transport inEscherichia coli

Ishita Mukerji

Proceedings of the National Academy of Sciences

ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

Zainab Ahdash

eLife, 2019

Preserving the membrane barrier for small molecules during bacterial protein translocation

Nature, 2011

The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic sec61p complex

Journal of Molecular Biology, 1999

A Large Conformational Change Couples the ATP Binding Site of SecA to the SecY Protein Channel

Ian Collinson

Journal of Molecular Biology, 2007

Integration of SecA protein into the Escherichia coli inner membrane is regulated by its amino-terminal ATP-binding domain

Molecular Microbiology, 1996

Positively charged residues influence the degree of SecA dependence in protein translocation across the< i> E. coli inner membrane

Gunnar von Heijne

1994

Two distinct anionic phospholipid-dependent events involved in SecA-mediated protein translocation

Megha Patro

Biochimica et Biophysica Acta (BBA) - Biomembranes

Structure of the SecY channel during initiation of protein translocation

Nature, 2013

Functionally Significant Mobile Regions of Escherichia coli SecA ATPase Identified by NMR

Robert Chou

Journal of Biological Chemistry, 2002

Using a Low Denaturant Model To Explore the Conformational Features of Translocation-Active SecA

Lila Gierasch

Biochemistry, 2012

Distinct Membrane Binding Properties of N- and C-terminal Domains of Escherichia coli SecA ATPase

Journal of Biological Chemistry, 2000

The Plug Domain of the SecY Protein Stabilizes the Closed State of the Translocation Channel and Maintains a Membrane Seal

Dana Boyd

Molecular Cell, 2007

Characterization of the supporting role of SecE in protein translocation

Irfan Prabudiansyah

Conformational stabilization and crystallization of the SecA translocation ATPase from Bacillus subtilis

Johann Deisenhofer

Acta Crystallographica Section D Biological Crystallography, 2001

Structural insight into the protein translocation channel

Current Opinion in Structural Biology, 2004

Identification of a Region of Interaction between Escherichia coli SecA and SecY Proteins

Journal of Biological Chemistry, 1997

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

Pascal F . Egea

Competition between Sec-and TAT-dependent protein translocation in Escherichia coli

Gunnar von Heijne

The EMBO Journal, 1999

Large conformational changes of a highly dynamic pre-protein binding domain in SecA

Maximilian Haase

Communications biology, 2018