Translocation of proteins through the Sec61 and SecYEG channels (original) (raw)

Bacterial protein translocation requires only one copy of the SecY complex in vivo

Tom Rapoport

Journal of Cell Biology, 2012

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The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic sec61p complex

Tom Rapoport

Journal of Molecular Biology, 1999

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Protein Translocation Is Mediated by Oligomers of the SecY Complex with One SecY Copy Forming the Channel

Tom Rapoport

Cell, 2007

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Structure of the SecY channel during initiation of protein translocation

Tom Rapoport

Nature, 2013

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Dynamic action of the Sec machinery during initiation, protein translocation and termination

Roman Tuma

eLife, 2018

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The Plug Domain of the SecY Protein Stabilizes the Closed State of the Translocation Channel and Maintains a Membrane Seal

Dana Boyd

Molecular Cell, 2007

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Structural insight into the protein translocation channel

Tom Rapoport

Current Opinion in Structural Biology, 2004

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Energy landscape steering mediates dynamic coupling in ATP-driven protein translocation by the bacterial Sec machinery

Roman Tuma

2019

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Atomic Model of the E.coli Membrane-bound Protein Translocation Complex SecYEG

Ian Collinson

Journal of Molecular Biology, 2005

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Structural determinants of protein translocation in bacteria: conformational flexibility of SecA IRA1 loop region

Raffaele Ragone, Pasquale Palladino

Journal of Peptide Science, 2011

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The structure of the Sec complex and the problem of protein translocation

Ian Collinson

EMBO reports, 2006

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Characterization of the supporting role of SecE in protein translocation

Irfan Prabudiansyah

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Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes

Tom Rapoport

Nature, 2007

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Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62

Katie Kuo

Nature Structural & Molecular Biology, 2021

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The Bacterial ATPase SecA Functions as a Monomer in Protein Translocation

Dana Boyd

Journal of Biological Chemistry, 2005

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Preserving the membrane barrier for small molecules during bacterial protein translocation

Tom Rapoport

Nature, 2011

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The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins

Ji Eun

Journal of cell science, 2014

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Two distinct anionic phospholipid-dependent events involved in SecA-mediated protein translocation

Megha Patro

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Crystal structure of a substrate-engaged SecY protein-translocation channel

Tom Rapoport

Nature, 2016

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Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

Pascal F . Egea

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Conserved motifs on the cytoplasmic face of the protein translocation channel are critical for the transition between resting and active conformations

Reid Gilmore

Journal of Biological Chemistry

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Mapping polypeptide interactions of the SecA ATPase during translocation

Tom Rapoport

Proceedings of the National Academy of Sciences, 2009

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Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation

David Feldheim

Molecular and cellular biology, 1992

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Structure of the native Sec61 protein-conducting channel

Richard Zimmermann

Nature communications, 2015

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Using a Low Denaturant Model To Explore the Conformational Features of Translocation-Active SecA

Lila Gierasch

Biochemistry, 2012

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Identification of a Region of Interaction between Escherichia coli SecA and SecY Proteins

D. Oliver

Journal of Biological Chemistry, 1997

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SecA-Mediated Protein Translocation through the SecYEG Channel

Amalina Ghaisani Komarudin

ASM Press eBooks, 2019

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Alignment of the protein substrate hairpin along the SecA two-helix finger primes protein transport inEscherichia coli

Ishita Mukerji

Proceedings of the National Academy of Sciences

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Structure of the post-translational protein translocation machinery of the ER membrane

Tom Rapoport

Nature, 2018

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Topology of the Integral Membrane Form of Escherichia coli SecA Protein Reveals Multiple Periplasmically Exposed Regions and Modulation by ATP Binding

D. Oliver

Journal of Biological Chemistry, 1997

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Positively charged residues influence the degree of SecA dependence in protein translocation across the< i> E. coli inner membrane

Gunnar von Heijne

1994

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A Large Conformational Change Couples the ATP Binding Site of SecA to the SecY Protein Channel

Ian Collinson

Journal of Molecular Biology, 2007

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Integration of SecA protein into the Escherichia coli inner membrane is regulated by its amino-terminal ATP-binding domain

D. Oliver

Molecular Microbiology, 1996

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Synthetic peptides identify a second periplasmic site for the plug of the SecYEG protein translocation complex

Ian Collinson, Richard Sessions

FEBS Letters, 2009

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Energy landscape steering in SecYEG mediates dynamic coupling in ATP driven protein translocation

Tara Sabir

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