Gastroretentive Drug Delivery Systems: A Review of Formulation Approaches (original) (raw)

GASTRORETENTIVE DRUG DELIVERY SYSTEM-An Overview

Journal of Pharmacy and Chemistry (An International Research Journal of Pharmaceutical and Chemical Sciences, 2014

Gastric emptying is a complex process and makes the performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 h. The floating or hydrodynamically controlled drug delivery systems are useful in such application. The present review addresses briefly about the floating drug delivery systems. Gastroretentive drug delivery systems provide drug delivery at the controlled rate and prolong the retention of dosage forms in gastrointestinal tract. In this review we will discuss the various aspects of the gastroretentive systems. These studies begin with the introduction to the gastroretentive systems along with advantages and factors controlling gastric retention of dosage forms have been discussed. Afterwards the discussion about the requirements for development of gastroretentive drug delivery systems and suitable and unsuitable drugs candidates are briefly explained. At the end, the polymers and the different other substances used in formulating hydro dynamically balanced, raft, muco-adhesive, floating, high density and magnetic systems of gastroretentive drug delivery systems are described. Various gastroretentive dosage forms of the different drugs and polymers utilized in them are presented in this review

Formulation Development and Evaluation of Gastro Retentive Drug Delivery Systems-A Review

In recent years many advancement has been made in research and development of Oral Drug Delivery System. Concept of Novel Drug Delivery System arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. Purpose of this review is to compile the recent literature with special focus on Gastro Retentive Drug Delivery Systems to give an update on pharmaceutical approaches used in enhancing the Gastric Residence Time (GRT). Various approaches are currently used including Gastro Retentive Floating Drug Delivery Systems(GRFDDS),swelling and expanding system, polymeric bioadhesive systems, modified-shape systems, high density system and other delayed gastric emptying devices. These systems are very helpful to different problem solve during the formulation of different dosage form. The present work also focuses on the polymers used in floating drug delivery systems mostly from natural origin. Floating drug delivery systems are less dense than gastric fluids; hence remain buoyant in the upper GIT for a prolonged period, releasing the drug at the desired/ predeterminedrate. This review article focuses on the recent technological development in floating drug delivery systems with special emphasis on the principal mechanism of floatation and advantages of achieving gastric retention, brief collection on various polymers employed for floating drug delivery systems etc. In addition this review also summarizes the In –Vitro and In-Vivo studies to evaluate their performance and also their future potential.

Approaches for Gastroretentive Drug Delivery Systems-A Review

Journal of Drug Delivery and Therapeutics, 2014

The purpose of writing this review on gastro retentive drug delivery systems was to compile the recent literature with special focus on floating drug delivery systems (FDDS) to achieve gastric retention. FDDS are of particular interest for drugs that are locally active and have narrow absorption window in stomach or upper small intestine, unstable in the intestinal or colonic environment, and exhibit low solubility at high pH value. It is known that differences in gastric physiology (such as, gastric pH, motility) exhibit both intra as well as inter subject variability demonstrating significant impact on gastric retention time and drug delivery behaviour.Thus, gastroretention helps to increase the gastric residence time and improve absorption of drugs with narrow absorption window. The recent developments of FDDS including the pharmacokinetic and pharmacodynamic aspects affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, advantages and limitations over the conventional drug delivery systems, and their classification and formulation aspects are covered in detail. This review also summarizes the studies to evaluate the performance and application of floating systems, and applications of these systems.

GASTRORETENTIVE DRUG DELIVERY SYSTEM- A REVIEW

Gastric emptying is a complex process and makes the in vivo performance of the drug delivery system uncertain. In order to avoid this fickleness, efforts have been made to increase the retention time of the dosage form, one such approach is the development to gastroretentive drug delivery system. Gastroretentive drug delivery system (GRDDS) is a type of novel drug delivery system which can remain in the stomach for prolonged period of time and there by increases gastric residence time of drugs, and also improves the bioavailability of drugs. These systems are widely used for the site specific delivery of drugs for the treatment of gastrointestinal diseases and disorders. Gastroretentive drug delivery systems are divided into several approaches like floating, hydrodynamically balanced systems, bioadhesive systems, swelling systems, high density systems, expandable systems etc, which are discussed in detail in the present review.

A Review Article on Gastroretentive Drug Delivery System

International journal of science and research, 2023

In recent years, gastroretentive drug delivery systems (GRDDS) have gained attention in the field of oral drug delivery systems. Oral controlled release and site-specific drug delivery systems have piqued the interest of pharmaceutical researchers seeking to improve therapeutic advantage. Gastroretentive drug delivery systems are one of these novel approaches to prolong gastric residence time, thereby targeting site-specific drug release in the stomach for local or systemic effects. Controlled-release dosage forms have been extensively used to improve therapy with several important drugs. Conventional oral dosage forms pose low bioavailability problems because of their quick gastric transition. To comprehend the various physiological challenges associated with achieving gastric retention, important factors controlling gastric retention from the stomach, especially for drugs that are less soluble in the intestine's alkaline pH. There are various gastroretentive approaches designed and developed until now, i.e., high density (sinking), floating, bio-or mucoadhesive, expandable, unfoldable, super porous hydrogel, and magnetic systems. Also, drugs that produce their local action in the stomach get quickly emptied and don't get sufficient residence time in the stomach. The system is useful for drugs that are unstable in the intestine or have low solubility or permeability in the small intestine.

AN OVERVIEW ON LIMITATIONS OF GASTRORETENTIVE DRUG DELIVERY SYSTEM Review Article

2011

Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. Floating drug delivery systems (FDDS) can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs, thereby improving bioavailability, reduced drug waste and improved solubility for drugs that are less soluble at a higher pH environment. In order to understand the various physiological barriers to achieve gastric retention, a thorough understanding of the important factors controlling gastric retention is essential.

An Overview on Gastroretentive Drug Delivery System: Current Approaches and Advancements

Current Research in Pharmaceutical Sciences, 2019

Gastroretentive Drug Delivery System (GRDDS) can elevate the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a constant period of time before it extends its absorption site. This includes floating system, dilation and expanding system, muco-adhesive system, high density system and other postponed gastric emptying devices. The present article briefly about the formulation consideration for GRDDS, factors controlling gastric retention time, advantages, disadvantages and evaluation of GRDDS.

A review on gastroretentive drug delivery system

Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. However, the development processes are faced with several physiological difficulties such as the inability to restrain and localize the system within the desired region of the gastrointestinal tract and the highly variable nature of the gastric emptying process. This variability may lead to unpredictable bioavailability and times to achieve peak plasma levels. The purpose of writing this review on gastroretentive drug delivery systems was to compile the recent literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastroretentive approaches designed and developed until now, i.e. high density (sinking), floating, bio-or mucoadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems. Finally, advantages of gastroretentive drug delivery systems were covered in detail.

A Review on Techniques and Applications of Gastroretentive Drug Delivery System

International Journal of Medical and Biomedical Studies

A Controlled release dose forms have been widely utilized to enhance treatment with a number of significant medications. However, a number of physiological challenges, including the inability to control and localize the system within the target region of the gastrointestinal tract and the extremely changeable nature of the gastric emptying process, pose challenges to the development processes. The bioavailability and periods needed to reach peak plasma levels may be unpredictable as a result of this diversity. The goal of this review on gastro retentive drug delivery systems was to gather the most recent research with a special emphasis on the numerous gastro retentive technologies that have lately emerged as leading approaches in the area of site-specific oral controlled release drug delivery. We have included crucial elements in order to comprehend numerous physiological challenges to achieve stomach retention.

GASTRORETENTIVE SYSTEM IMPROVES THE PROBLEMS OF ORAL DRUG DELIVERY SYSTEMS: A REVIEW

Gastroretention helps to provide better availability of new products with new therapeutic possibilities and substantial benefits for patients. Dosage forms with a prolonged gastric residence time, i.e. gastro retentive dosage forms (GRDFs), will provide us with new and important therapeutic options. GRDFs extend significantly the period of time over which the drug may be released. Thus, they not only prolong dosing intervals, but also increase patient compliance beyond the level of existing controlled release dosage forms. This application is especially effective in delivery of sparingly soluble and insoluble drugs. A number of approaches have been used to increase the GRT of a dosage form in a variety of concepts. These include Floating drug delivery systems, Bioadhesive systems, Swelling and expanding systems, Modified shape systems and High density drug delivery systems. This review also discusses the recent advances in the field of gastroretentive drug delivery systems. KEYWORDS: Delivery System, Gastroretentive, Gastric Residence Time, Bioavailability.