A nested case-control study of the association of Helicobacter pylori infection with gastric adenocarcinoma in Korea (original) (raw)
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Association of Helicobacter Pylori Infection and Gastric Cancer
Post-Graduate Medical Journal of NAMS, 2015
Introduction: Gastric cancer remains one of the most common cancers worldwide and the second leading cause of cancer mortality in the world. Helicobacter Pylori is a major risk factor. Early detection of infection and eradication therapy will probably reduce the incidence of stomach cancer. This study is carried out to see the association of the H. pylori infection in gastric cancer patients in our population. Methods: This is a prospective cross sectional descriptive study done in Gastroenterology unit, Department of medicine, National Academy of Medical Sciences, Bir Hospital. Patients who were suspected of cancer of stomach clinically as well as endoscopically,their thorough history was taken and demographic profiles like age, sex and geographic location were recorded. Similarly, symptoms, risk factors and endoscopic finding were recorded. Likewise, result of rapid urease test and histopathology results were documented. Results: Male patients were seen to be more frequently affec...
Association of Helicobacter pylori infection with gastric carcinoma
Bangladesh Medical Research Council Bulletin, 2009
This is a cross-sectional study on 140 gastric neoplasm subjects diagnosed by upper gastrointestinal endoscopy. The commonest site of cancer was the antrum of stomach (52.86%), followed by the antrum and body (32.86%) and only body region (12.14%). Histology revealed adenocarcinoma in all patients. The associations of Helicobacter pylori with gastric cancer were studied by rapid urease test, serology and histology by Giemsa stain. The positivity of H. pylori determined by serology in 70 patients (50%) was significantly higher than those determined by histology 22 patients (15.71%). No significant association between H. pylori infection and gastric cancer was observed.
Journal of gastroenterology, 1997
We conducted a case-control study to examine the association of Helicobacter pylori infection as a risk factor in gastric cancer in the Japanese population. Serum IgG antibodies for Helicobacter pylori were determined in 55 consecutive patients with gastric cancer and in 75 age- and sex-matched mass survey subjects and 57 age- and sex-matched cancer-free patients with conditions considered at a high risk for development of gastric cancer (precancerous condition). We examined the histology in all subjects and particular focus was placed on the extent of Helicobacter pylori-associated gastritis. The seroprevalence of Helicobacter pylori in gastric cancer patients (82%) and those with a precancerous condition (89%) was significantly higher (P < 0.005) than that in the mass survey subjects (60%). Positive relative risk associations were found for patients with gastric cancer (odds ratio, 3, with 95% confidence intervals of 1.69-5.33) and those with a precancerous condition (odds rati...
Gastric Adenocarcinoma and Helicobacter pylori Infection
JNCI Journal of the National Cancer Institute, 1991
Helicobacter pylori infection, thought to be causally related to chronic gastritis, may also be associated with an increased risk of gastric cancer. To determine whether an association with gastric cancer does exist, we retrospectively evaluated serum samples from 69 patients with histologically confirmed gastric adenocarcinoma (32 with cancer at the cardia and 37 with cancer at other sites) and from 218 patients with one of three categories of nongastric cancers, with other gastric cancers, or with benign gastric neoplasms. These samples were compared with samples from 252 cancer-free control subjects, a group comprising 76 asymptomatic volunteers and 176 persons with nonmalignant disorders. Serum samples collected from cancer patients prior to surgery and from cancer-free controls were tested for antibodies to H. pylori by using a highly sensitive and specific IgG enzymelinked immunosorbent assay. The risk of H. pylori infection in the case patients relative to the control subjects was estimated with the use of multivariate logistic regression analysis to adjust for potential confounding variables. Antibodies to H. pylori were detected in 65% of the patients with noncardia gastric cancer but in only 38% of the patients with gastric cancer located at the cardia. A significant as-
Incidence of helicobacter pylori infection and gastric cancer : an 8-year hospital based study
Acta medica Indonesiana
To observe the tendency of decreased prevalence of H pylori infection in a 14 year-period and observe the prevalence of intestinal metaplasia and gastric cancer. All patients who were diagnosed with dyspepsia and underwent esophagogastroduodenoscopy in Cikini hospital Jakarta from January 1998 until December 2005 were evaluated. We evaluated the histopathologic result of H pylori, the presence of intestinal metaplasia and gastric cancer. Data was grouped for 1 year period of time and was presented descriptively. Decreased prevalence of H. Pylori infection was found, from 12.8% in 1998, 12.4% in 1999, 14.7% in 2000, 9.6% in 2001, 11.9 % in 2002, 3.8% in 2003, 2.3% in 2004, 2.9% in 2005. Intestinal metaplasia was 4.7% in 1998, 3.2% in 1999, 3.1% in 2000, 2.3 % in 2001, 7.6% in 2002, 8.3% in year 2003, 6.5% in 2004, 7.1% in 2005. Prevalence of gastric cancer was 2.2% in 1998, 0.25% in 1999, 1.1% in 2000, 1.1% in 2001, 1.1% in 2002, 1.8% in 2003, 1.7% in 2004, 3.9% in 2005. There was de...
Helicobacter PyloriInfection in Gastric Cancer: A Study of 84 Cases from Asir Region
Annals of Saudi Medicine, 1994
Gastric cancer can be divided into three histologic types: intestinal and diffuse adenocarcinoma, and malignant lymphoma. To determine whether Helicobacter pylori was associated with either cancer type, we reviewed histologic sections from stomachs of 84 patients with the diagnosis of gastric cancer. Of 63 patients with histologic evidence of intestinal adenocarcinoma, 53 (84%) contained H. pylori in noncancerous tissue compared with six (66.7%) of nine patients with diffuse adenocarcinoma (odds ratio = 2.65; Z= 1.048; P>0.05) and with eight (66.7%) of 12 patients with non-Hodgkin malignant lymphoma of the stomach (odds ratio = 2.65; Z=0.826; P>0.05). Our findings are compared with reported data from other countries and we are not aware of similar reports from the Kingdom of Saudi Arabia.
[Helicobacter pylori infection in gastric cancer]
Nippon rinsho. Japanese journal of clinical medicine
The relationship between Helicobacter pylori (H. pylori) infection and gastric cancer becomes the topics in the world, since some reports thereon in 1991. The purpose of this study was to know the prevalence of H. pylori infection in many patients with gastric cancer. We examined the H. pylori IgG antibody in 507 patients with gastric cancer resected surgically in our hospital from 1989 to 1991, retrospectively. For the test of H. pylori IgG antibody, HM-CAP EIA kit (Italy, ENTERIC PRODUCTS Co.) was used. The overall detection rate of H. pylori IgG antibody was 75% (378/507). H. pylori infection was significant significantly frequent in early cancer (80%, 231/288) than advanced cancer (67%, 147/219). But, the other clinicopathological features such as sex, age, histological type, location and the degree of intestinal metaplasia were not significantly correlated with H. pylori infection. To evaluate the risk of H. pylori infection for gastric cancer, we are going to plan a matched-pa...
Association of Helicobacter pylori infection and stomach cancer: our experience
International Surgery Journal, 2018
Background: Infection with Helicobacter pylori (H. pylori) has been linked with chronic atrophic gastritis, an inflammatory precursor of gastric adenocarcinoma. There are data on the epidemiology, pathophysiology, and histology of this disease that show that Helicobacter pylori gastritis has an important role in gastric carcinogenesis. However, it has to be considered that only very few of those infected with Helicobacter pylori will develop gastric cancer. Hence, it will be a major target of future research to identify individuals who carry a greater risk for developing gastric cancer, and therefore may benefit from eradication of Helicobacter pylori in terms of gastric cancer prevention. Various studies revealed that approximately more than 50% of the world’s human population is infected by Helicobacter pylori. In underdeveloped countries, this association is shown to be much higher according to different studies.Methods: This study was conducted over a period of 36 months from 1s...