Natural remedies to covid-19: An inflammatory disease (original) (raw)
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Potential medicinal plant remedies and their possible mechanisms against COVID-19: A review
Ife Journal of Science, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak was first reported in Wuhan, a city in Hubei Province of China in December, 2019 and is known to be responsible for the novel coronavirus disease (COVID-19). COVID-19 was declared a pandemic in March, 2020 and since then, it has caused a number of deaths in over 200 countries around the world. Extensive researches have continued in the search of effective vaccines or drug compounds against SARS-CoV-2 and a total of 64 vaccines are currently in clinical trials with 12 currently approved for use by different regulatory bodies, depending on the country. Since the outbreak of SARS-CoV-2, many countries have utilised traditional herbal medicines alongside conventional drugs for the treatment of infected patients. In this review, traditional medicines used to prevent or treat SARS-CoV-2 infection are listed along with the plant parts as used by the traditional healers. Additionally, the possible mechanisms responsible f...
Role of herbal medicine for controlling coronavirus (SARS-CoV-2) disease (COVID-19)
This review paper highlights the use of herbal medicine in the management of the coronavirus disease COVID-19 (SARS-CoV-2) pandemic, which has caused a worldwide outbreak of respiratory illness. This is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is zoonotic infecting both animal and human. Vaccines are the most promising solution to mitigate new viral strains. The Indian system of holistic medicine known as "Ayurveda" plays an important role in controling the viral disease SARS-CoV-2 and other health disorders. Dietary therapy and herbal medicine could be a complementary preventive therapy for COVID-19 (SARS-CoV-2). Plants have been used as a expression systems for the production of diagnostic reagents and pharmaceutical proteins often described as "molecular farming. On the basis of literature survy presented, some of the plant secondary metabolites that showed prominent antiviral activity against coronaviruses SARS-CoV-2 through impeding the main machinery used in their pathogenesis and replication cycle. The in vitro, in vivo, and in silico investigations revealed numerous plant-derived compounds with promising anti-SARS-CoV and anti-SARS CoV-2 activity. Therefore, this review gathered all antiviral plants in a single platform to facilitate the laboratory-based research for the development of novel drug/molecular therapeutics to overcome the SARS-CoV-2 and future pandemic situations. Further detailed clinical trial experiments should be conducted for the scientific validation.
Preventive Medicinal Plants and their Phytoconstituents against SARS-CoV-2/COVID-19
Pharmacog. Res., 2021
Pandemic coronavirus disease-2019 (COVID-19) is an infectious disease caused by the newly discovered virus "Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2)". Considering the present scenario of COVID-19 outbreak and its impact on humankind, holistic remedies with respect to herbal medicine validated from ethnopharmacological rationale are now targeting approaches globally as a preventive care against SARS-CoV-2. Aim: This review is primarily focused on to deliver a concise fact of the coronaviridae family, pathophysiology, mechanism of action, ethnopharmacological validated Indian herbs for inhibiting the virus with possible targets. Experimental procedure: In this study, science mapping tool Bibliometrix R-package was used to perform bibliometric analysis and building data matrices for keywords co-occurrence investigation, country-wise scientific production; collaboration between the countries worldwide, co-word analysis on topic "keywords associated with SARS-CoV-2 and medicinal plants". Results and Conclusion: Our findings is to deliver a concise knowledge about the coronaviridae family, pathophysiology, possible targets for managing the SARS-CoV-2, in addition to potential medicinal plants and their phytoconstituents against COVID-19. Target-specific inflammatory pathways due to post infection of SARS e.g. NLRP3, p38-MAPK, Metallopeptidase Domain 17; endocytosis pathways e.g. Clathrin, HMGB1 pathways are primarily highlighted along with relevant interleukins and cytokines, which directly/indirectly triggering to immune system and play a significant role. Based on selective pathways and potential lead, the outcome of our elaborated study put forward selected Indian medicinal plants that hold a very high probability as preventive care in this global crisis.
Role of herbal medicine for controlling coronavirus (SARS-CoV-2) disease (COVID-19)(2021)
This review paper highlights the use of herbal medicine in the management of the coronavirus disease COVID-19 (SARS-CoV-2) pandemic, which has caused a worldwide outbreak of respiratory illness. This is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is zoonotic infecting both animal and human. Vaccines are the most promising solution to mitigate new viral strains. The Indian system of holistic medicine known as "Ayurveda" plays an important role in controling the viral disease SARS-CoV-2 and other health disorders. Dietary therapy and herbal medicine could be a complementary preventive therapy for COVID-19 (SARS-CoV-2). Plants have been used as a expression systems for the production of diagnostic reagents and pharmaceutical proteins often described as "molecular farming. On the basis of literature survy presented, some of the plant secondary metabolites that showed prominent antiviral activity against coronaviruses SARS-CoV-2 through impeding the main machinery used in their pathogenesis and replication cycle. The in vitro, in vivo, and in silico investigations revealed numerous plant-derived compounds with promising anti-SARS-CoV and anti-SARS CoV-2 activity. Therefore, this review gathered all antiviral plants in a single platform to facilitate the laboratory-based research for the development of novel drug/molecular therapeutics to overcome the SARS-CoV-2 and future pandemic situations. Further detailed clinical trial experiments should be conducted for the scientific validation.
Biomedicines, 2021
The worldwide transmission of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a deadly or devastating disease is known to affect thousands of people every day, many of them dying all over the planet. The main reason for the massive effect of COVID-19 on society is its unpredictable spread, which does not allow for proper planning or management of this disease. Antibiotics, antivirals, and other prescription drugs, necessary and used in therapy, obviously have side effects (minor or significant) on the affected person, there are still not clear enough studies to elucidate their combined effect in this specific treatment, and existing protocols are sometimes unclear and uncertain. In contrast, it has been found that nutraceuticals, supplements, and various herbs can be effective in reducing the chances of SARS-CoV-2 infection, but also in alleviating COVID-19 symptoms. However, not enough specific details are yet available, and precise scientific studies to validate the appro...
ROLE OF NATURAL PRODUCT IN PREVENTING COVID-19
The current pandemic of COVID-19 that is spreading across countries originated in Wuhan, China. The single cause of this highly communicable disease is a novel coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the seventh known virus of the Coronaviridae family capable of infecting humans. The World Health Organization (WHO) welcomes innovations around the world including repurposing drugs, traditional medicines and developing new therapies in the search for potential treatments for COVID-19. In this study the effectiveness of certain medicinal plants for mild and moderate Covid-19 patients were analyzed literately. Thirty number of plants were studied according to their phytochemical properties, traditional uses, therapeutic actions and certain in-vitro studies from articles published in international multidisciplinary journals, newspapers, books, recognized health organizations websites and interviews from the clinicians. The results showed that the plants possess certain phytochemicals which would be effective to boost the immune system, preventing the viral load in the human host, reduce the inflammatory cytokines and improve the blood cells. However pre-clinical and clinical studies should be conducted to prove the efficacy in scientific manner.
Traditional Herbal Folk Medicine used for controlling Corona virus (SARS-COV-2) Disease (COVID-19)
International Journal of Innovation Scientific Research and Review, 2021
This review paper developed on the basis of literature survey highlights the use of traditional herbal folk medicine for controlling the deadly outbreak of corona virus (SARS-CoV-2) mutants, Delta variant (B.1.617.2) and Delta Plus (AY. 1) causing major health issue with the highest viral infections and deaths. Severe acute respiratory syndrome (SARS-CoV-2) is a pandemic respiratory infections viral disease. SARS-CoV-2 syndrome is also causing an unusual type of pneumonia leading to the lungs infection. Botanical drugs constantly become a worthy therapeutic alternatives against viral infections including corona virus (SARS-CoV-2). Therefore, there is an urgent need for the agents that can act against SARS-CoV-2 as a precautionary measures which boost our immunity during Covid-19. In this review paper, there are many medicinal plants listed have been found inhibited the SARS-CoV-2 viral replications, and acts as immunity booster. The use of spices and herbs may also play a significant role against viral infections. Therefore, herbal and dietary therapy plays significant role in controlling many infectious diseases including corona virus (SARS-CoV-2) affecting human health. However, there is no clinical evidence to support herbal medicine as remedy for corona virus and warranted further scientific evidence. Further detailed clinical trial experiments should be conducted for the scientific validation. This review paper updates about plants either used as expression patterns for plant based vaccines or as antiviral drugs as a medicine for controlling SARS-CoV-2 outbreak since the disease is becoming endemic.
Efficacy of Herbal Medicines as Remedies against COVID-19
EAS Journal of Pharmacy and Pharmacology
Objective: Coronaviruses belong to the order Nidovirales, family Coronaviridae, and four genera, namely: alpha, beta, gamma, and delta. In December 2019, a novel coronavirus was first officially reported in Wuhan City of China. Consequently, on February 11, 2020, the CSG named the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); it causes the disease dubbed Covid-19. The virus was officially declared pandemic by WHO, on March 11, 2020. Up till date, no drug, including the existing ones, has been approved for covid-19 treatment. The objective of this work, is to carry out a review on proven herbal extracts and the phyto-compound contents, for possible antiviral properties against SARS-CoV-2, and thus, as potential candidates for Covid-19 vaccine. Materials and Methods: Investigation into proven plant species against respiratory tract diseases was carried out between 1st to 30th of July, 2020 via: (a) Conduction of interview with traditional herbal healers and users...
A Possible Role of Medicinal Plants in finding a Cure for Covid-19
Life and Science
Since the outbreak, COVID-19 (SARS-CoV-2) has affected more than 24 million people. COVID-19 pandemic appears to lack any effective antiviral drug or vaccine therapy. Previously, it has been reported that medicinal plants are effective against pneumonia caused by coronavirus (SARS-CoV). Secondary metabolites derived from medicinal plants also play pivotal role in strengthening the immune system as well as the killing of pathogens or viruses. The present review summarized the medicinal plants and their secondary metabolites that have antiviral potentials. Further studies are required to evaluate these medicinal plants and their secondary metabolites for possible treatment of COVID-19.