Microbiological profile with Antibiotic Sensitivity Pattern for Chronic Suppurative Otitis Media in A Tertiary Hospital, Indonesia (original) (raw)
Related papers
IP Journal of Otorhinolaryngology and Allied Science, 2020
Chronic suppurative otitis media (CSOM) is one of the most common and an important global public health problem leading to hearing impairment and is particularly prevalent in developing countries. Even in this era of powerful antibiotics, due to increased irrational use of wide spectrum antibiotics, the resistance in the bacterial isolates is common. The objective of the study was to determine the aerobic bacterial etiology of patients with CSOM and the antimicrobial susceptibility of the bacteria isolated.A descriptive cross sectional study was carried out in 112 patients suffering from chronic discharging ear. Pus samples were cultured aerobically. Antibiotic sensitivity testing was performed with standard antibiotic discs using modified Kirby-Bauer disk diffusion method.Out of 112 patients, 70 (62.5%) were females. Among 112 swab cultures, 98 (87.5%) were positive for the growth of organism and 14 (12.5%) were sterile cultures. Among them Staphylococcus aureus (42.24%), Pseudomon...
IP innovative publication pvt. ltd, 2019
Introduction: Chronic suppurative otitis media (CSOM) is a condition of middle ear characterized by recurrent or persistent discharge through a chronic perforation of tympanic membrane. CSOM causes mild to moderate conductive hearing loss in more than 50% of cases. As there is mild to moderate conductive deafness, this in turn in children is likely to affect language and cognitive development. CSOM produces chronic mastoiditis by contiguous spread. If untreated it can lead to irreversible local destruction of middle ear structures and various intracranial and extra cranial complications. The organisms causing CSOM and their susceptibility pattern to antibiotics varies in different regions and also changes over time. Therefore it is important to study the organisms causing CSOM and their susceptibility pattern at regular intervals to see the pattern of organisms prevalent in patients with CSOM in that particular region and their antibiotic susceptibility to start empherical treatment for patients with CSOM by clinicians. Objectives: To determine the bacteriological profile and antimicrobial sensitivity pattern of organisms causing chronic suppurative otitis media. Materials and Methods: Ear swabs collected from patients of suspected CSOMduring the period of 1 year from January 2018 to December 2018 were included in the study. Samples were processed for routine microscopy and culture and the organisms were identified by standard methods and antimicrobial susceptibility testing was done as per CLSI (Clinical and laboratory Standards Institute) guidelines. The isolates were identified by colony morphology, Gram’s stain and biochemical reactions and antibiotic susceptibility tests performed by CLSI recommended by Kirby-Bauer disc diffusion method. Results: Out of the 132 ear swab samples, 114 yielded growth. 18 samples showed no growth. Most common organism isolated was Staphylococcus aureus 43(37.7%) followed by Pseudomonas aeruginosa 32(28.1%). Other organisms isolated include Klebsiella spp12(10.6%), Coagulase negative staphylococci 11(9.6%), Proteus spp 8(7%), E scherichia coli 5(4.4%) and Citrobacter spp 3(2.6%). Amikacin, Gentamycin and Ciprofloxacin were found to be effective against most of Gram positive and negative organisms. Conclusion: CSOM is a disease of middle ear which if not given timely treatment can lead to irreversible ear damage and intracranial and extracranial complications. Identification of organisms causing CSOM and appropriate antibiotic sensitivity pattern is helpful in the treatment of CSOM and reduce complications. Hence in the era of increasing antimicrobial resistance, the knowledge of bacterial organisms causing CSOM and their antimicrobial pattern in that particular area help clinicians in choosing appropriate antibiotics for the empherical treatment of CSOM.
Annals of Clinical Chemistry and Laboratory Medicine, 2015
BACKGROUND: Chronic suppurative otitis media (CSOM) is an inflammation of the middle ear and mastoid mucosa with perforation of tympanic membrane. Mainly disease of developing countries like Nepal, CSOM results because of illiteracy, poverty and poor hygiene. Haphazard use of antibiotics and increasing use of newer one has led to persistent change in microbial flora. The aim of this study is to determine the incidence of CSOM and its causative agents. METHODS: The study included 123 samples from 105 patients attending ENT department of Dhulikhel hospital. Samples were processed in microbiology department for both bacteria and fungi using standard operating protocol. Antibiotic susceptibility testing was performed for all bacterial isolates by Kirby Bauer disc diffusion method and the result were interpreted according to clinical and laboratory standard institute (CLSI) guideline. RESULTS: Out of 105 patients, 55 were male and 50 female patients. Highest incidence of CSOM was observe...
2020
Background: Chronic suppurative otitis media (CSOM) is defined as a persistent infection of the middle ear with a perforated tympanic membrane and draining exudate for more than 6 weeks. Information about the organism responsible for COSM and their antibiotic susceptibility pattern is an important for effective treatment. Aim: This study aims to develop protocol for empirical treatment by determining aerobic bacterial profile and antibiotics susceptibility in patients of chronic suppurative otitis media (CSOM) at a secondary care hospital in North India. Material and Methods: A cross-sectional study was conducted at ENT department of the secondary care hospital in North India on 85 patients, middle ear discharge sample was collected under strict aseptic conditions and antibiotic susceptibility done as per Clinical Laboratory Standards Institute guidelines. Result: 85 ear swabs were collected, and 89 bacterial isolates were identified, of which 62 (72.94%) sample with mono-microbial ...
Microbial Assessment of Chronic Suppurative Otitis Media in a Tertiary Care Center of Rajasthan
https://www.ijhsr.org/IJHSR\_Vol.7\_Issue.2\_Feb2017/IJHSR\_Abstract.019.html, 2017
Introduction: Chronic Suppurative Otitis Media (CSOM) is defined as infection of the middle ear that lasts for more than three months and is accompanied by otorrhoea and tympanic membrane perforation. Aims: Purpose of the study was to determine the prevalence of microbiological agents in CSOM, associated risk factors and establish antimicrobial resistance pattern of these microorganisms. Materials and Methods: The study was conducted after ethical approval by ethical committee in Department of Microbiology, Dr. S. N. Medical College, Jodhpur Rajasthan. Two pus swabs were collected with sterile cotton swabs from CSOM patients attending ENT OPD. Isolation, identification and characterization of bacterial isolate were done by standard phenotypic microbiological procedure. Observations & Results: Out of 150 cases 137(91.34%) was culture positive and 13 (8.66%) no growth (sterile) was obtained. Peak age of presentation was 11-20 years. Out of 150 cases 58% were males and 42% females. Most of these resides in rural area 53.3% and 46.7% belongs to urban area .Among the 150 cases 134 (89.3%) were unilateral while 16 (10.7%) bilateral CSOM patients. Out of total 78% patients already received antibiotic treatment while remaining 22% patients did not receive any treatment. Bacterial isolates were found to be present in 127 (92.7%) cases and rest 10 (7.3%) was Fungal was isolates. Pseudomonas aeruginosa showed highest resistance to Ceftazidime and least resistance to imipenem. Staphylococcus aureus showed highest resistance to Methicillin and least resistance to linezolid. Conclusion: The increasing rate Ceftazidime resistance and MRSA in our study is likely due to misuse of antibiotics and decrease concerns about infections caused by antibiotic resistant bacteria.
Chronic suppurative otitis media(CSOM) has been a source of a tremendous health predicament since time immemorial and even today it is immensely intricate. It is an important cause of hearing impairment which in turn may cause serious long term effect on language, auditory and cognitive development and on educational development.Knowledge of the prevailing flora and their susceptibility to antimicrobials will guide the clinician as to prescribing an empirical regimen so that a better and more specific management can be provided to the patients. Hence this study is done in present secenario to isolate the organims associated with CSOM and its susceptibility pattern. To identify the bacterial and fungal profile of Chronic Suppurative Otitis Media patients. 120 patients attending ENT OPD in Navodaya Medical College Hospital and Research Centre were analysed from Nov 2009 to Oct 2010. Using predefined inclusion and exclusion criteria, samples were obtained using sterile cotton microswabs. These were cultured for microbial flora and were identified . Drug susceptibility was done using Kirby Bauer disc diffusion method.The most common organism isolated was Pseudomonas aeruginosa 33% followed by Staphylococcus aureus 25.8% among the 91 bacterial isolates. This was followed by Proteus mirabilis 20.6%, Enterobacter aerogenes and Streptococcus spp at 4.1%. The organisms were most prevalant in winter and early spring between Nov-Feb. Also maximum number of cases were seen in age group of 21-30 years.The organisms were sensitive to gatifloxacin, cefoperazone sulbactum and ceftriaxone.Fungal isolates accounted for 6.2% of the organism with Aspergillus flavus 3.1%, Aspergillus niger 2.1% and Candida albicans 1%.The study suggests that Pseudomonas aeruginosa and Staphylococcus aureus are the most common etiological agents of CSOM. Most of the strainwere sensitive to fluoroquinolones and cephalosporins.
https://www.ijhsr.org/IJHSR\_Vol.6\_Issue.3\_March2016/11.pdf, 2016
Introduction: Chronic suppurative otitis media (CSOM) is the most common infection of the ear characterized by recurrent, purulent discharge from the middle ear through a nonintact tympanic membrane. Its incidence has remained relatively higher in developing countries Aim/Objectives: This study was carried out in department of Microbiology, Dr.S.C.G.M.C, Nanded to determine bacteriological profile and its antibiotic susceptibility in patients with CSOM Materials & Methods: A total of 470 patientsaged 2-60 years admitted to ENT ward from July 2014 to April 2015 were studied. Ear swabs were taken and cultured aerobically on blood agar and Mac Conkeyagar. The organisms isolated were identified by standard microbiological methods and antibiotic sensitivity pattern was determined Results: Out of 470 patients, 245(52.12%) were female and 225(47.87%) were male. Peak prevalence of otitis media was documented in age group 2-10 years (39.41%). Amongst 470 ear swabs, 460(97.87%) were culture positive and 30(6.52%) were having 2 isolates. Pseudomonas aeruginosa (37.95%) was the commonest isolate followed by Staphylococcus aureus (21.83%), Coagulase Negative Staphylococcus (18.16%), Klebsiella pneumoniae (15.51%) and Escherichia coli (8.36%). Antibiotics sensitive to P. aeruginosa were Imipenem (100%), Gentamicin (65.2%) and Tobramycin (61.7%) and those resistant were Ceftazidime (71.6%) and Piperacillin (59%). Both K. pneumoniae and E. Coli species showed highest sensitivity to Amikacin (96.8%) and Ciprofloxacin (65.3%) and resistance to Amoxyclav (62.2%), Cefotaxime (61.8%) and Ceftriaxone (61.3%). Amongst Gram positive isolates, Vancomycin (100%), Clindamycin (64.3%) and Cefoxitin (53.9%) were highly sensitive and Penicillin (11.2%) was most resistant drug Conclusion: Routine use of topical antibiotics for any case of CSOM as empirical therapy must be reviewed and judicial use of antibiotics is recommended to minimise antibiotic resistance
International Journal of Otorhinolaryngology and Head and Neck Surgery, 2021
Chronic suppurative otitis media (CSOM) is a disease frequently encountered by the Otorhinolaryngologist. The World Health Organization defines CSOM as chronic inflammation of the middle ear and mastoid air cells characterized by a perforated tympanic membrane and otorrhea for a period of more than two weeks. 1 It is a disease of multiple aetiologies and known for its recurrence and persistence despite adequate treatment at the primary healthcare level. Its importance lies in its consequences on hearing impairment, chronicity, local and central sequalae. It affects different cultural and racial groups in both developing and industrialized countries. 2 Epidemiological studies have reported a high incidence of the disease in children belonging to lower socioeconomic groups. 3 The active form of the disease persists into adulthood in a very small percentage of the affected population. 4