Chitosan–hydroxyapatite composites (original) (raw)
Related papers
Properties of chitosan-hydroxyapatite Composites Review
Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of chitosan and calcium phosphates has grown significantly over the last two decades due to its renewable and biodegradable source, also because of the increase in the knowledge of its functionality in the technological and biomedical applications. The excellent biocompability, biofunctionality, and non-antigenic property make the chitosan an ideal polymer material for tissue regeneration. The biomaterials compositions for hard tissue regeneration in many different shapes are deriving from the junction of two or more different materials, containing organic and inorganic substances, which could be used as implants in orthopedic surgery for a scaffolds base for medical applications.
Chitosan-hydroxyapatite composite obtained by biomimetic method as new bone substitute
2009 Advanced Technologies for Enhanced Quality of Life (AT-EQUAL), 2009
buffered lysozyme solution and the degraded polysaccharide was measured; the SEM data, before and after degradation, revealed that composites morphology had not appreciable changed. 'In vitro' degradation studies indicate that these composite have slighter degradation rate which is coupled to the degree of N-deacetylation, hydrophilicity and crystallinity. Swelling properties measurements in simulated body fluids have shown that the swelling ratio of composites is decreased when the content of Hap is higher. The obtained results revealed that obtained Cs-Hap composites are promising materials as bone substitute due to their adequate swelling properties and controlled degradation rate.
Journal of Biomedical …, 2012
A novel biomimetic technique for obtaining chitosan-calcium phosphates (Cs-CP) scaffolds are presented: calcium phosphates are precipitated from its precursors, CaCl 2 and NaH 2 PO 4 on the Cs matrix, under physiological conditions (human body temperature and body fluid pH; 37 o C and pH ¼ 7.2, respectively). Materials composition and structure have been confirmed by various techniques: elemental analysis, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), and scanning electron microscopy (SEM). FTIR and SEM data have shown the arrangement of the calcium phosphates-hydroxyapatite (CP-Hap) onto Cs matrix. In this case the polymer is acting as glue, bonding the calcium phosphates crystals. Behavior in biological simulated fluids (phosphate buffer solution-PBS and PBS-albumin) revealed an important contribution of the chelation between ÀNH þ 3 and Ca 2þ on the scaffold interaction with aqueous mediums; increased quantities of chitosan in composites permit the interaction with human albumin and improve the retention of fluid. The composites are slightly degraded by the lysozyme which facilitates an in vivo degradation control of bone substitutes. Modulus of elasticity is strongly dependent of the ratio chitosan/calcium phosphates and recommends the obtained biomimetic composites as promising materials for a prospective bone application. V C 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 700-708, 2012. How to cite this article: Tanase CE, Popa MI, Verestiuc L. 2012. Biomimetic chitosan-calcium phosphate composites with potential applications as bone substitutes: Preparation and characterization. J Biomed Mater Res Part B 2012:100B:700-708.
Synthesis of calcium-phosphate and chitosan bioceramics for bone regeneration
Anais da Academia Brasileira de Ciências, 2001
Bioceramic composites were obtained from chitosan and hydroxyapatite pastes synthesized at physiological temperature according to two different syntheses approaches. Usual analytical techniques (X-ray diffraction analysis, Fourier transformed infrared spectroscopy, Thermo gravimetric analysis, Scanning electron microscopy, X-ray dispersive energy analysis and Porosimetry) were employed to characterize the resulting material. The aim of this investigation was to study the bioceramic properties of the pastes with non-decaying behavior from chitosan-hydroxyapatite composites. Chitosan, which also forms a water-insoluble gel in the presence of calcium ions, and has been reported to have pharmacologically beneficial effects on osteoconductivity, was added to the solid phase of the hydroxyapatite powder. The properties exhibited by the chitosan-hydroxyapatite composites were characteristic of bioceramics applied as bone substitutes. Hydroxyapatite contents ranging from 85 to 98% (w/w) res...
Chitosan Composites for Bone Tissue Engineering—An Overview
Marine Drugs, 2010
Bone contains considerable amounts of minerals and proteins. Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] is one of the most stable forms of calcium phosphate and it occurs in bones as major component (60 to 65%), along with other materials including collagen, chondroitin sulfate, keratin sulfate and lipids.
This short review shows the present status of research & development in chitosan/calcium phosphate composites studies. It is a promising biomaterial to face new problems and challenges in the field of materials science, biology and medicine, related with musculoskeletal tissue, bone and cartilage are under extensive investigation in regenerative medicine and tissue engineering research. A large number of people who needs medical devices rising every year and is related with many factor such bone fractures, defects or diseases in addition to other various problems which need to be cured make the scientist research and develop a great number of biodegradable and bioresorbable biocomposites. New developments in this interdisciplinary field related with new materials, methods possibly will increase in the near future the feasibility to design a new generation of biocomposites tailored for specific patients and disease states.
Preparation and characterization of chitosan and hydroxyapatite composite
International Journal of Science and Research Archive, 2024
Chitosan and hydroxyapatite (HAp) composites were prepared at different ratios (60% chitosan & 40% HAp, 50% chitosan & 50% HAp, 40% chitosan & 60% HAp). The mixtures are dissolved in a 2% acetic acid solution and heated to about 60°C-70°C with continuous stirring for about 1 hour. After that, the solutions are naturally dried on heat-sealing paper placed above a glass sheet. After about 24 hours, chitosan and hydroxyapatite composite films are prepared. Fourier Transform Infrared Spectroscopy (FTIR) analysis showed that Hydroxyapatite is mainly found at lower wave numbers in the range 400-600 cm-1. X-ray diffraction patterns were showed, the crystalline properties of the composites increase with Hydroxyapatite. Differential Thermal Gravimetry (DTG) analysis of the composites indicated that the material is thermally stable up to 300°C. This paper aims to review the literature concerning chitosan-hydroxyapatite composites for bone restoration and discuss the primary methods of preparation and mechanical properties of these materials.
Molecules, 2021
The aim of this work was to fabricate novel bioactive composites based on chitosan and non-organic silica, reinforced with calcium β-glycerophosphate (Ca-GP), sodium β-glycerophosphate pentahydrate (Na-GP), and hydroxyapatite powder (HAp) in a range of concentrations using the sol–gel method. The effect of HAp, Na-GP, and Ca-GP contents on the mechanical properties, i.e., Young’s modulus, compressive strength, and yield strain, of hybrid composites was analyzed. The microstructure of the materials obtained was visualized by SEM. Moreover, the molecular interactions according to FTIR analysis and biocompatibility of composites obtained were examined. The CS/Si/HAp/Ca-GP developed from all composites analyzed was characterized by the well-developed surface of pores of two sizes: large ones of 100 μm and many smaller pores below 10 µm, the behavior of which positively influenced cell proliferation and growth, as well as compressive strength in a range of 0.3 to 10 MPa, Young’s modulus ...
Chitosan-Calcium Phosphate Complex Composite
Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers such as chitosan and its derivatives, and minerals such as calcium phosphates has grown significantly over the last two decades due to its renewable and biodegradable source, increasing the knowledge and functionality of composites in technological and biomedical applications. The properties of bone in health and disease attract much attention. A great proportion of the population need those medical devices for hard tissue regeneration and/or replacement, the pressure on the health systems in all countries became substantial. The short review focus in biomaterials such as chitosan and calcium phosphates composites with excellent properties such as biocompatibility, biofunctionality, and non-antigenic, showing the feasibility and ideal material to treat musculoskeletal disorders for hard tissue regeneration.
Chitosan Composite Biomaterials for Bone Tissue Engineering—a Review
Regenerative Engineering and Translational Medicine, 2020
The bone is a highly dynamic tissue with the remarkable ability to remodel and is in a continuous cycle of resorption and renewal as a result of internal mediators and external mechanical demands. Researchers have doubled their efforts to develop bone graft substitutes in order to overcome limitations that surround current bone loss treatment and the annual increase of cases dealing with bone loss and dysfunction. Chitosan has been identified by many researchers as a suitable biomaterial for bone tissue engineering applications. Chitosan holds various favourable properties, yet the mechanical strength of pure chitosan scaffolds hinders its application in bone tissue engineering. By combining chitosan with other materials, the advantageous properties can potentially be retained or even enhanced and limiting properties can be mediated. Chitosan has been blended in varying combinations with a variety of materials that include ceramics, synthetic polymers, natural polymers and other additives. This review will focus on chitosan-based biomaterials that have been developed for bone tissue engineering. Lay Summary The application of chitosan-based biomaterials in the bone tissue engineering field has become increasingly popular among researchers. Chitosan has many favourable properties; however, limitations have hindered its application in bone tissue engineering. To overcome these limitations, chitosan has been blended with other polymers (natural and synthetic), ceramics and other additives. These composite materials are combined to eliminate unfavourable properties and retain favourable properties.