Basal Cell Carcinoma Presentation, Histopathological Features and Correlation with Clinical Behaviour (original) (raw)
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Histopathological Features of the Eyelid Basal Cell Carcinomas
2020
Basal cell carcinomas (BCC) make up about 90% of malignant tumors of the eyelids. Although they are generally slow-growing tumors, in the periocular region can cause significant morbidity due to orbital invasion. In the present study we followed the associations between the various types of BCC with the depth of invasion, respectively the Breslow stage (BS) and with the pT category. The study included a number of 92 cases of eyelid BCC from the Plastic Surgery and Ophthalmology Departments of the Craiova County Emergency Clinical Hospital which were processed and diagnosed in the Pathological Laboratory of the same hospital. Histopathological analysis of the 92 BCCs indicated that in 72 cases the tumors were composed of a single growth pattern, and in 20 cases they were composite, associating two or more growth patterns. The cases with a single growth pattern corresponded in 53 cases of nodular BCC, in 9 cases of infiltrative BCC, in 2 cases of superficial BCC and in 8 cases of micr...
Basal cell carcinoma of eyelid
IP innovative publication pvt. ltd, 2019
A 55 year male patient presented with progressive growth over left lower eyelid measuring 1.5 x 1 cm. The local examination showed ulceroproliferative growth with irregular margins and everted edges. On histopathological examination diagnosed as basal cell carcinoma of lower eyelid. We are presenting this case for its clinical manifestations and histopathological findings. Keywords: Eyelid tumor, Basal cell carcinoma, Pigment.
Characteristics and Factors Related to Eyelid Basal Cell Carcinoma in Saudi Arabia
PURPOSE: Data on basal cell carcinoma (BCC) from the Middle East are deficient. We present the features and management outcomes for BCC over the last 36 years in Saudi Arabia. SUBJECTS AND METHODS: This retrospective chart review included BCC patients diagnosed and treated at Saudi Arabia between 1980 and 2016. Data were collected on patient demographics, clinical and histopathological characteristics of the lesions, management, and follow‑up. RESULTS: One hundred and twenty‑six patients with BCC were included in this study. The incidence of BCC in Saudi Arabia is 0.8 cases a year. The median age of the patients was 71 years. BCC affected 58.9% of males. The lower lid was the most common site of occurrence (52.7%). Clinically, BCC was most commonly recognized as a mixed lesion (41.1%) and 50.4% were histologically nodular. Risk factors for poor prognosis included tumor localization in the medial aspect of the lid, tumor size > 5 mm, histological subtype being ulcerative or morphea forms, affected margins, and recurrent lesions. CONCLUSION: BCC is a rare condition in Saudi Arabia. The clinical features and histopathology of BCC in Saudi Arabia are similar to the patterns observed in other regions of the world. Early detection and timely management mitigates the extensive destructive ocular/orbital damage due to BCC and results in better patient outcomes.
2015
Introduction: Basal Cell Carcinoma (BCC) typically affects older individuals with Predilection for sun-exposed skin (face, hands) small, well-circumscribed, pearly tan-gray papule devoid of scale lesions enlarge with time and tend to ulcerate (rodent ulcers). Basal cell nevus syndrome: multiple basaloid hamartomas on the cutaneous surface associated with palmar keratotic pits, jaw cysts, and basal cell carcinomas in non-sun-exposed locations. BCC rarely metastasize; when they do, the primary lesion is usually advanced. Aim: The aim of our study was to determine the frequency of various types of BCCs encountered in our practice, to delineate the spectrum in our setup and to determine the different histological patterns, anatomical location, site predilection, and age and sex incidence. Materials and methods: The present study was carried out in the department of pathology in a tertiary care centre. The study was prospective (2years) as well as retrospective (5 years) and was done during the period of September 2004 to September 2011 i.e., 7 years. Results : In the present study 21 cases of BCC were seen and accounted for 26.25% of all the malignant tumors of skin. Conclusions : In the present study majority (85%) of the lesions of BCC were located on head and neck region, average age of cases of basal cell carcinoma was 65.6 years, and solid type of BCC was most common type.
Histological and Clinical Features of Primary and Recurrent Periocular Basal Cell Carcinoma
ISRN …, 2012
Background. Basal cell carcinoma (BCC) is the most common malignancy of the eyelids. Medial canthal BCCs tends to recur more often. Purpose. To evaluate the clinical and histological features of primary and recurrent periocular BCC, in order to identify any existing associations. Methods. Data from 87 patients (71 primary and 16 recurrent) were analyzed in this study. All patients underwent tumor excision with frozen section margin control at the Goldschleger Eye Institute between 1/1995 to 12/1997. Statistical analysis was performed to identify possible associations between histological and clinical characteristics of primary and recurrent BCC. Main Outcome Measures. Anatomical location, clinical presentation, and histology of peri-ocular BCC. Results. No association was found between histopathological and clinical characteristics of BCC. Similar features with regard to eyelid location and histology were found in primary and recurrent peri-ocular BCCs, whereas recurrent BCCs tended to involve a greater eyelid extent with a longer duration of symptoms. Medial canthal BCCs, morpheaform, or sclerosing histology were not more common in the recurrent BCC group. Conclusions. Similar clinical and histological characteristics were noted in primary and recurrent periocular BCC, implying that incomplete surgical excision rather than anatomical location or histological features is the main cause for recurrence.
European Journal of Ophthalmology, 2020
Purpose: To investigate the relation between the eighth edition of the American Joint Committee on Cancer staging system and histological risk classification for primary eyelid basal cell carcinoma. Methods: Retrospective, observational case series of patients undergoing excisional biopsy for primary eyelid basal cell carcinoma in two tertiary centres between 2008 and 2018. Patients with <6 months of follow-up were excluded. Outcomes measured included histological subtype, American Joint Committee on Cancer 7 and 8 staging. Results: A total of 222 cases were included over a 10-year period, with a mean (range) follow-up of 25.74 (6–120) months and a median (range) age of 70 (28–93) years. According to American Joint Committee on Cancer 8, the most common T category was T1a (64%), followed by T1b (18%) and T2a (8%). Of the 222 specimens, 183 (82.43%), 17 (7.66%), 19 (8.56%) and 3 (1.35%) were staged as IA, IB, IIA and IIB, respectively. The most common histological subtype was nodu...
Eyelid Basal cell carcinoma in a healthy child
Journal of pediatric ophthalmology and strabismus, 2014
Basal cell carcinoma is rare in children and usually is associated with genetic or immune predisposing factors. A 14-year-old otherwise healthy boy who had an eyelid basal cell carcinoma is presented. The tumor was in the subcilliary area in the lateral part of the lower eyelid, was ulceronodular with some pigmentation, and had grown over the past 6 months. The patient's medical history was unremarkable. Systemic and immunologic studies did not find any abnormality that could present a predisposition to skin cancer. The tumor was excised and the resulting eyelid defect was repaired with a semicircular flap. During a follow-up period of 44 months, the patient did not develop any recurrence, de novo tumor, or extraocular disease of any significance.
Surgical Approach of Basal Cell Carcinoma on the Lower Eyelid: A Case Report
Basal cell carcinoma (BCC) is a common malignant tumor, originating from the basal cell layer of the epidermis. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. The most common location is in the head and neck area, including the eyelids. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Surgical excision using Mohs surgery is the first line of treatment for periocular BCC. Careful consideration should be made on reconstructing the eyelid after successful mass removal. Early diagnosis and treatment lead to a better functional and aesthetic outcome after surgery.
Journal of Babol University of Medical Sciences, 2023
Background and Objective: Basal cell carcinoma is the most common human malignancy that has been increasing in recent years. The aim of this study is to determine the demographic and histopathological pattern of this malignancy in the pathology departments of state hospitals in Babol from 2013 to 2020. Methods: In this retrospective study, after reviewing the existing files with the final diagnosis of basal cell carcinoma from 2013 to 2020, the patients' information including age, gender, lesion location and microscopic subgroup were recorded and analyzed. Findings: In this study, 367 cases were obtained from Shahid Beheshti and Shahid Yahyanejad Hospitals in Babol with the diagnosis of basal cell carcinoma. The mean age of people in both genders was 67±10.89 years. 69% of the samples were men and 31% were women (p<0.001). The highest frequency was from the scalp area (134 samples) and the lowest frequency was related to the chest (3 samples). The most common histopathology subtype was nodular type and the rarest types were metatypical and clear cell carcinoma. A statistically significant relationship was observed between the location of the sample and gender (p=0.023); the cheek in men and the nose in women were more common than the other gender. The highest incidence was seen in 2017 with 83 cases, which was a significant increase compared to the previous year. Conclusion: Based on the results of this study, the high incidence of basal cell carcinoma in the head and face area of elderly people, especially men, reveals the need to inform high-risk communities and to be more familiar with therapists, especially dentists who are in close eye contact with the face.
Study of Basal Cell Carcinoma and Its Morphological Spectrum
2019
Original Research Article Introduction: Basal cell carcinoma is the most common skin malignancy worldwide with a predilection towards sun exposed areas especially head and neck areas. It is a slow growing tumour with propensity for local invasion, however metastasis is seldom seen. The histopathological variants seen in BCC are nodular, micronodular, cystic, superficial, pigmented, adenoid, infiltrating, sclerosing, keratotic, infundibulocystic, metatypical, basosquamous etc. Aim: The aim was to study morphological spectrum of BCC cases in a tertiary care hospital in southern region of New Delhi. Materials and Methods: This study was a retrospective analysis in which nine cases of BCCs were included. Result: The mean age of presentation was 68.4 years. There was female preponderance (77%). Face was the most common location (88%) with cheek being the commonest and the ulceration was the most common clinical presentation (66.6%). Among the nine cases of BCC’s, 33.3% were solid, 22.2% ...