In vivo analgesic activity of Salvia wiedemannii Boiss. used in Turkish Folk Medicine (original) (raw)
Related papers
Analgesic Activity of Salvia wiedemannii Boiss. Used in Turkish Folk Medicine
acgpubs.org
The aerial part of Salvia wiedemannii Boiss. (Lamiaceae) has been used for treatment of peptic ulcers and relieving pain in Turkish folk medicine. To evaluate the analgesic effect of S. wiedemannii, tail flick and acetic acid-induced writhing tests were used in mice. The chloroform extract (500 mg/kg, i.p.) obtained from S. wiedemannii showed significant analgesic activity on tail flick assay, while water, ethanol and butanol extracts of the plant had no activity on the same test. Chloroform extract (500 mg/kg, i.p.) also inhibited number of writhings induced by acetic acid. Chloroform extract provided analgesic effects similar to morphine. Its effect was quick and durable. This in vivo study demonstrates that S. wiedemannii has strong analgesic effect as the public believed.
2012
Ethnopharmacological relevance: Salvia officinalis L. has been used as a traditional herbal medicine for gastric disturbances and inflammatory processes. This study investigated the toxicological, antinociceptive and anti-inflammatory effects of the hydroalcoholic extract (HE) from leaves of Salvia officinalis and its isolated compounds in mice. Materials and methods: Mice were treated with HE before the induction of nociceptive response by chemical agents (acetic-acid, formalin, glutamate, capsaicin and cinnamaldehyde). Total leukocytes and plasma extravasation induced by acetic acid and paw oedema induced by glutamate, capsaicin and cinnamaldehyde were also measured. The antinociceptive effect of carnosol and ursolic acid/oleanolic acid were evaluated on formalin and cinnamaldehyde models. Results: In the acute toxicity test the value of estimated LD50 for HE was 44.7579 g/kg. Oral administration of HE (10, 30 and 100 mg/kg) inhibited the number of writhings, total leukocytes and plasma extravasation induced by acetic acid. In the formalin test, HE reduced both neurogenic and inflammatory phases, effect that was affected by naloxone. The glutamate-, capsaicin-and cinnamaldehyde-induced nociception and paw oedema were reduced by HE at doses that did not affect the locomotor activity of mice in the open field test. Carnosol (10 mg/kg) and ursolic acid/oleanolic acid (30 mg/kg) inhibited the inflammatory phase of formalin and the nociception and mechanical allodynia induced by cinnamaldehyde. Conclusions: These results demonstrate that HE presents significant anti-inflammatory and also antinociceptive effects on chemical behavioral models of nociception that involves an opioid mechanism. In addition, carnosol and ursolic acid/oleanolic acid contained in this plant appears to contribute for the antinociceptive property of the extract, possibly through a modulatory influence on TRPA1-receptors. However, further studies regarding the precise site and the mechanism of action of HE and carnosol and ursolic acid/oleanolic acid merited exploring further.
Potential Activity of Medicinal Plants as Pain Modulators: A Review
Pharmacognosy Journal, 2021
This review aims to demonstrate the relevance that medicinal plants and their promising results have in prevention and treatment of pain. The neurophysiological bases of pain have been analyzed and the potential mechanisms of action have been proposed, it has also been determined that the main experimental models used for the evaluation of the analgesic potential are: acetic acid-induced writhing test, formalin test, hot-plate test, capsaicin-induced nociception, cinnamaldehyde-induced nociception, glutamate-induced nociception, tail-flick test and tail immersion test. There are countless medicinal plants with potential analgesic activity, in some of them main responsible compounds for the activity are flavonoids (vitexin, quercetin, naringenin, astragalin, eupatilin), alkaloids (scotanamine B, bullatine A, S-(+)dicentrine, stephalagine, lappaconitine), terpenoids (p-cymene, thymol, menthol, citronellol, myrcene, carvacrol, linalool) and saponins (siolmatroside I, cayaponoside D, cayaponoside B4, cayaponoside A1); however, all studies have only been carried out up to pre-clinical stages. Therefore, it is recommended to carry out kinetic studies of the most remarkable natural compounds, evaluate mixtures of active compounds for diminishing doses to avoide possible side effects, and continue with clinical studies of medicinal plants whose safety has already been reported.
Analgesic Effect of Quercetin 3,7-O-DIMETHYL Ether Isolated from Salvia Officinalis
2018
To evaluate the analgesic effect of flavonoid quercetin 3,7-O-dimethyl ether isolated from ethyl acetate fraction of the methanol extract of Salvia officinalis. The dried leaves of Salvia officinalis were subjected to extraction with methanol, and then it was fractioned by water and ethyl acetate solvent. The antinociceptive activity of flavonoid quercetin 3,7-Odimethyl ether isolated from ethyl acetate fraction was assessed using heat-induced (hot-plate) and chemical-induced (acetic acid and formalin) nociception models in mice and rats. Involvement of opioid system and cyclic guanosine monophosphate (cGMP) pathway were also investigated using naloxone and 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), respectively. Pretreatment with quercetin 3,7-O-dimethyl ether significantly (p < 0.05) and dose-dependently increased the hot plate latency time. It also reduced the number of abdominal constrictions and paw lickings (in both early and late phases) induced by acetic acid and ...
Pain management in mice using the aqueous and ethanol extracts of four medicinal plants
East African Medical Journal, 2004
Background: There are many traditionally used analgesic plants in Ethiopia. They, however, have not been subject to scientific investigation for their efficacy and safety. Objective: To evaluate both prophylactic and relieving effects of aqueous and ethanol extracts of four traditionally used medicinal plants in Ethiopia. Design: An experimental design in which five group of albino mice weighing 30-35 grams representing positive and negative control, and extract treated groups respectively. The extracts, standard drugs and normal saline were administered into GIT by gavage to evaluate the analgesic effect.
Potential Activity of Medicinal Plants as Pain Modulators
This review aims to demonstrate the relevance that medicinal plants and their promising results have in prevention and treatment of pain. The neurophysiological bases of pain have been analyzed and the potential mechanisms of action have been proposed, it has also been determined that the main experimental models used for the evaluation of the analgesic potential are: acetic acid-induced writhing test, formalin test, hot-plate test, capsaicin-induced nociception, cinnamaldehyde-induced nociception, glutamate-induced nociception, tail-flick test and tail immersion test. There are countless medicinal plants with potential analgesic activity, in some of them main responsible compounds for the activity are flavonoids (vitexin, quercetin, naringenin, astragalin, eupatilin), alkaloids (scotanamine B, bullatine A, S-(+)dicentrine, stephalagine, lappaconitine), terpenoids (p-cymene, thymol, menthol, citronellol, myrcene, carvacrol, linalool) and saponins (siolmatroside I, cayaponoside D, cayaponoside B4, cayaponoside A1); however, all studies have only been carried out up to pre-clinical stages. Therefore, it is recommended to carry out kinetic studies of the most remarkable natural compounds, evaluate mixtures of active compounds for diminishing doses to avoide possible side effects, and continue with clinical studies of medicinal plants whose safety has already been reported.
Analgesic and Anti-Inflammatory Effects of Hydroalcoholic Extract of Salvia multicaulis on Male Rats
Quarterly of Horizon of Medical Sciences, 2015
Activity of the oil of Salvia officinalis L. against Botrytis ... [11] Effect of planting density and harvest date on yield and chemical composition of ... [12] Chemical composition and phytotoxic effects of essential oils of ... [13] Salvimultine, a new noricetexanediterpene from the roots ... [14] Biological activities of the essential oils and methanol extract of ... [15] Identification of essential oil components by ... [16] Ethical considerations in relation to pain in ... [17] The formalin test: A quantitative study of ... [18] Antagonism of orexin-1 receptors attenuates swim-and restraint ... [19] Analgesic effectiveness of ketorolac compared to meperidine in ... [20] A method for determining loss of ... [21] An accurate and simple method for measurement of ... [22] Antimicrobial and antioxidative activities of the essential oils and ... [23] The analgesic effect and possible mechanism of ... [24] Analgesic Effect Of Aqueous ... [25] Study on the different dosages of ... [26] Assessment of aqueous extract of ... [27] Antiinflammatory and analgesic activities of ThesiumchinenseTurcz extracts and ... [28] Investigation of antinociceptive and ... [29] Effect of Euphorbia helioscopia on ... [30] Antinociceptive effect of cinnamon extract on formalin induced pain in ... [31] The effect of Artemisia sieberiBesser on inflammatory and neurogenic pain in ... [32] Noxious heat activates all capsaicin-sensitive and also a subpopulation of capsaicin-insensitive dorsal root ... [33] Molecular mechanisms of ... [34] Intervention of morphine and naloxone on analgesic effects of origanumvulgare extract in ...
In this paper, three decoctions of different Danshen medication forms (crude SM pieces, SM formula granule, liquored SM pieces) were compared to explore their comparative analgesic and anti-inflammatory effect. In three mice models, the hot plate test and the writhing test were used to analyze their analgesic effect, and the ear edema test was carried out to assess their anti-inflammatory effect. Compared with the corresponding model control group, the results suggested that the three different SM decoctions all had definite effect in prolonging t he latency to licking a hind paw or jumping, reducing the writhing rate within 30 min and narrowing the deviation between the weight of ears. Furthermore, liquored SM pieces and SM formula granule had better analgesic and anti-inflammatory effect than crude SM pieces and no obvious differences appeared between liquored SM pieces and SM formula granule.
Analgesic and antipyretic effects of Dodonaea angustifolia and Salvia africana-lutea
Journal of Ethnopharmacology, 2001
Water extracts of Dodonaea angustifolia L. and Sal6ia africana-lutea L., were investigated for analgesic and antipyretic activities using acetic acid writhing and hot plate tests, and lipopolysaccharide (LP)-induced pyrexia test in mice and rats, respectively. D. angustifolia and S. africana-lutea significantly inhibited acetic acid-induced writhing and also significantly delayed the time of reaction of mice to thermal stimulation produced by the hot plate. D. angustifolia and S. africana-lutea significantly reduced fever induced by LP. Paracetamol produced similar effects to D. angustifolia and S. africana-lutea on the acetic acid-induced writhing but has no effect on hot plate-induced nociception and on pyrexia produced by LP. These data indicate the analgesic and antipyretic potential of D. angustifolia and S. africana-lutea.