Process optimization for fabrication of gellan based electrospun nanofibers (original) (raw)
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Influence of gelatin type on physicochemical properties of electrospun nanofibers
Scientific Reports
This study explores the fabrication of nanofibers using different types of gelatins, including bovine, porcine, and fish gelatins. The gelatins exhibited distinct molecular weights and apparent viscosity values, leading to different entanglement behavior and nanofiber production. The electrospinning technique produced nanofibers with diameters from 47 to 274 nm. The electrospinning process induced conformational changes, reducing the overall crystallinity of the gelatin samples. However, porcine gelatin nanofibers exhibited enhanced molecular ordering. These findings highlight the potential of different gelatin types to produce nanofibers with distinct physicochemical properties. Overall, this study sheds light on the relationship between gelatin properties, electrospinning process conditions, and the resulting nanofiber characteristics, providing insights for tailored applications in various fields.
Effect of Poly(vinyl alcohol)/Chitosan Ratio on Electrospun-nanofiber Morphologies
Advanced Materials Research, 2012
Series of poly (vinyl alcohol)/chitosan (PVA/CS) electrospun nanofibers with different weight ratio of PVA and CS were fabricated by electrospinning method. The surface morphology, diameter, and structure of electrospun nanofibers were investigated by scanning electron microscopy (SEM). As a result of PVA and CS composition measurements, the electrospun nanofibers morphologies were mainly affected by weight ratio of the polymer solution. When increasing the chitosan content in the blend solution, the electrospun nanofibers could hardly form. This result indicates that the electrospun nanofiber formation is enhanced by chitosan content.
A Novel Study of Electrospun Nanofibers Morphology as a Function of Polymer Solution Properties
Electrospinning is a process of production fibers with diameters ranging from the submicron down to the nanometer size by applying a high voltage to a polymer solution. The important parameters in the morphology of electrospun polymer fibers are polymer structure, polymer solution properties, processing conditions, and ambient parameters. In the present work electrospinning of polyacrylonitrile (PAN) has been attempted to generate uniform nanofibers without beads. Electrospinning was performed at various concentrations ranging from 4 to 18 w/v%. The effects of polymer solution properties on electrospinnability of the PAN/DMF solutions have investigated. Fiber morphology was observed under a scanning electron microscopy (SEM). For the polymer electrospun from low concentration (Be<2), polymer droplets have formed. For the polymer electrospun from semi-dilute solution concentration (2<Be<3.5), the formation of nanofiber with beads. Uniform fiber formation was observed at Be>4. The relationship between solution viscosity and its concentration is in the form: η 0.0205C 4.16 and relation between the diameter of electrospun the PAN nanofiber and solution concentration is in the form: d 0.0326C 3.45 .
2013
Gelatin, a naturally-occurring biopolymer, was electrospun. It has been recognized that although gelatin can be easily dissolved in water the gelatin / water solution was unable to be electrospun into ultra-fine fibers. Gelatin solutions were prepared in a single solvent system [glacial acetic acid].The electrospinning was carried out under fixed electrostatic field strength of 20 kV/18 cm and the polarity of the emitting electrode was positive. The effects of gelatin concentration on morphology and/or size of the electrospun materials were observed by scanning electron microscopy (SEM). Electrospinning of 30-50% w/v gelatin solutions in acetic acid produced beads, or smooth fibers, depending on the concentration range. Only smooth fibers were observed at the concentration range of 40-50 % w/v, with their diameter ranging between 69-138 nm and 98-345 nm respectively. Further lower or higher concentration was inapplicable in electrospinning at ambient conditions. The gelatin fiber ma...
2021
The nanofibrous scaffold that mimics the extracellular matrix in structure has gained immense popularity, especially in the tissue engineering field, in the last decade. Several techniques have been utilized for fabricating nanofibrous scaffold s. Electrospinning is one of the most popular techniques to generate the nanofibrous scaffold, owing to processability, a wide variety of polymers and materials used, and affordability. This research aims to fabricate a smooth and uniform nonfibrous structure from poly (vinyl alcohol) and glycine aqueous solution. The effect of aqueous solution concentration and PVA to Gly different ratios on electrospinnability was investigated qualitatively utilizing scanning electron microscopy. Three different concentrations have been investigated 6 (w/v) %, 8 (w/v) %, and 10 (w/v) %, each one of these concentrations have been electrospun in different PVA to Gly weight ratios 4:1, 4:2, 4:3, and 4:4. The nanofibrous structure was attained with 8 (w/v) % and 10 (w/v) % with average fiber diameter in the range of 232±66 nm to 591±186 nm. Therefore, the morphology of nanofibers was attributed to the effect of solution concentration, as well as was attributed to the electrospinning parameters including needle-to-collector distance, feeding rate, and applied voltage.
Polymers, 2022
Nanofiber fabrication is attracting great attention from scientists and technologists due to its applications in many fields of life. In order to design a nanosized polymer-based drug delivery system, we studied the conditions for the fabrication of electrospun nanofibers from poly (vinyl alcohol) (PVA) and chitosan (CS), which are well-known as biocompatible, biodegradable and non-toxic polymers that are widely used in the medical field. Aiming to develop nanofibers that can directly target diseased cells for treatment, such as cancerous cells, the ideal choice would be a system that contains the highest CS content as well as high quality fibers. In the present manuscript, it is expected to become the basis for improving the low bioavailability of medicinal drugs limited by poor solubility and low permeability. PVA–CS nanofibers were obtained by electrospinning at a PVA:CS ratio of 5:5 in a 60% (w/w) acetic acid solution under the following parameters: voltage 30 kV, feed rate 0.2 ...
Effect of Molecular Weight on the Morphology of Electrospun Poly ( Vinyl Alcohol ) Nanofibers
2014
Morphological characteristics of electrospun PVA nanofibers were investigated in terms of polymer molecular weight was reported in this paper. The change in the morphology depending on the polymer concentration of electrospinning solution and the applied voltage were addressed. The fiber diameter increased with the increase in the molecular weight and polymer concentration and applied voltage and the average nanofiber diameter variation was found to be between 175.83 and 735.69 nm.
Electrospun Polymer Nanofibers: Processing, Properties, and Applications
Polymers
Electrospun polymer nanofibers (EPNF) constitute one of the most important nanomaterials with diverse applications. An overall review of EPNF is presented here, starting with an introduction to the most attractive features of these materials, which include the high aspect ratio and area to volume ratio as well as excellent processability through various production techniques. A review of these techniques is featured with a focus on electrospinning, which is the most widely used, with a detailed description and different types of the process. Polymers used in electrospinning are also reviewed with the solvent effect highlighted, followed by a discussion of the parameters of the electrospinning process. The mechanical properties of EPNF are discussed in detail with a focus on tests and techniques used for determining them, followed by a section for other properties including electrical, chemical, and optical properties. The final section is dedicated to the most important applications...
Nanomaterials (Basel, Switzerland), 2017
Electrospun nanofibers of poly (vinyl alcohol) (PV) were obtained to improve dispersion of cellulose nanocrystals (CNC) within hydrophobic biopolymeric matrices, such as poly(lactic acid) (PLA). Electrospun nanofibers (PV/CNC)n were successfully obtained with a final concentration of 23% (w/w) of CNC. Morphological, structural and thermal properties of developed CNC and electrospun nanofibers were characterized. X-ray diffraction and thermal analysis revealed that the crystallinity of PV was reduced by the electrospinning process, and the incorporation of CNC increased the thermal stability of biodegradable nanofibers. Interactions between CNC and PV polymer also enhanced the thermal stability of CNC and improved the dispersion of CNC within the PLA matrix. PLA materials with CNC lyophilized were also casted in order to compare the properties with materials based on CNC containing nanofibers. Nanofibers and CNC were incorporated into PLA at three concentrations: 0.5%, 1% and 3% (CNC...