Recent progress in elucidating signalling proteolytic pathways in muscle wasting: Potential clinical implications (original) (raw)

The ubiquitin–proteasome system and skeletal muscle wasting

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Ubiquitin ligases MuRF1 and MAFbx in human skeletal muscle atrophy

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Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control

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Regulation of ATP-ubiquitin-dependent proteolysis in muscle wasting

Laure Voisin, Daniel Taillandier

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The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms

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Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting

William Mitch

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Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading

Takeshi Nikawa

Molecular and Cellular Biology, 2009

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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

Doreen Drujan, Michael J. Gonzalez

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The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy

Lloyd White, Victoria Foletta

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Apoptosis signalling is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditions

Sílvia Busquets

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During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

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The initiation factor eIF3-f is a major target for Atrogin1/MAFbx function in skeletal muscle atrophy

Carlos Segura

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Muscle wasting associated with cancer cachexia is linked to an important activation of the atp-dependent ubiquitin-mediated proteolysis

Josep Argilés

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

Claudia Sandri, Anne Picard, Alfred Goldberg

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Atrogin-1/MAFbx and MuRF1 Are Downregulated in Aging-Related Loss of Skeletal Muscle

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Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

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Molecular mechanisms activating muscle protein degradation in chronic kidney disease and other catabolic conditions

William Mitch

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Mechanisms stimulating muscle wasting in chronic kidney disease: the roles of the ubiquitin-proteasome system and myostatin

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Clinical and experimental nephrology, 2013

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ARTICLE IN PRESS G Model Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced acute kidney injury

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Regulation of skeletal muscle atrophy

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Insulin Resistance Accelerates Muscle Protein Degradation: Activation of the Ubiquitin-Proteasome Pathway by Defects in Muscle Cell Signaling

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Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

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Muscle wasting in patients with end-stage renal disease or early-stage lung cancer: common mechanisms at work

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Control of Skeletal Muscle Atrophy in Response to Disuse: Clinical/Preclinical Contentions and Fallacies of Evidence

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Strategies for suppressing muscle atrophy in chronic kidney disease: Mechanisms activating distinct proteolytic systems

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Journal of Renal Nutrition, 2005

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Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

Alfred Goldberg

Proceedings of the …, 2001

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Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced Acute Kidney Injury

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Muscle wasting in chronic kidney disease: the role of the ubiquitin proteasome system and its clinical impact

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Pediatric nephrology (Berlin, Germany), 2008

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Oxidative stress as a therapeutic target during muscle wasting: considering the complex interactions

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Regulation of Muscle Protein Degradation: Coordinated Control of Apoptotic and Ubiquitin-Proteasome Systems by Phosphatidylinositol 3 Kinase

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MuRF1/TRIM63, Master Regulator of Muscle Mass

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