Metastatic mucoepidermoid carcinoma of the lung: A case report (original) (raw)
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Mucoepidermoid carcinoma of the lung: a case report and literature review
Case reports in oncological medicine, 2013
Introduction. Mucoepidermoid carcinoma (MEC) of the lung is a rare form of lung cancer that is classified into low grade and high grade based on histological features. Surgical resection is the primary treatment for low-grade MEC with excellent outcomes, while high-grade MEC is a more aggressive form of malignancy. Clinical Case. We report a case of a 46-year-old woman who presented with dyspnea on exertion. Imaging studies revealed a mass involving the right upper lobe bronchus. Bronchoscopy, surgical resection, and pathological examination revealed a low-grade MEC with tumor-free margins. No adjuvant treatment was given. Discussion. Primary pulmonary MEC is a rare type of lung cancer with only few reported cases. This patient illustrates a typical presentation for low-grade MEC wherein surgical resection is considered curative. In contrast, high-grade MEC is a more aggressive malignancy with a poorer outcome. The role of targeted therapy directed against EGFR or a novel CRTC1-MAML...
Mucoepidermoid carcinoma of the lung: a rare entity
Oxford medical case reports, 2015
A 38-year-old lady presented with mild fever and dry cough of 1 week duration. Her chest X-ray showed right middle lobe collapse and consolidation. CT thorax revealed a mass in the right middle lobe. Subsequent bronchoscopy showed a growth completely occluding the right middle lobe bronchus and extending proximally into bronchus intermedius. Right bilobectomy (middle and lower lobes) with lymphadenectomy was performed. All the histomorphological features were suggestive of a low-grade mucoepidermoid carcinoma (MEC). MEC is one of the very rare neoplasms of the lung comprising <1% of all lung tumours. Low-grade MEC has a better prognosis than high-grade tumour, the latter being similar to that of non-small-cell lung carcinoma.
Mucoepidermoid carcinoma of the lung: a case report
Journal of Cardiothoracic Surgery, 2011
Mucoepidermoid carcinoma of the lung (MEC) is a tumor of low malignant potential of bronchial gland origin. MEC and adenoid cystic carcinoma are both considered to be salivary gland-type neoplasms. MECs are comparatively rare with an incidence of all lung cancers. We recently encountered a case of this type of lung cancer. A 60-year-old man was found to have an abnormal shadow in the left lower lung field on a regular checkup for lung cancer at his company. Chest radiography and CT revealed a mass shadow measuring 30 mm in diameter in the left lower lung field. Bronchoscopy revealed a protuberant tumor in the S9 bronchus, leading to a diagnosis of low-grade MEC by transbronchial lung biopsy. He underwent left lower lobe resection and mediastinal lymph node dissection using VATS. Tumor cells had a scattering of mucus-producing epithelial components in papillary growth of stratified squamous epithelia with anisokaryosis and minimal pleomorphism, indicating a diagnosis of MEC. Because the postoperative course was good and the tumor was low-grade, no adjuvant treatment was administered. The patient has had no signs of tumor recurrence for 9 months, to date, since resection of the tumor
A rare form of the lung cancer: Mucoepidermoid carcinoma: A case report
Journal of Surgery and Medicine, 2018
Mucoepidermoid carcinoma (MEC) of the lung is a rare form of lung cancer that is classified into low grade and high grade based on histological features. For Mucoepidermoid Carcinoma of the Lung, surgery is the most commonly used and most effective form of treatment. Surgical resection is the primary treatment for low-grade MEC with excellent outcomes but high-grade MEC is a more aggressive form of this malignancy.
Mucoepidermoid lung carcinoma: diagnostic review (Atena Editora)
Mucoepidermoid lung carcinoma: diagnostic review (Atena Editora), 2022
Mucoepidermoid carcinoma is a rare cause of primary bronchial lung malignancy. These tumors are more common in young people. The diagnosis is preferably made with Fibronchoscopy and the standard treatment for the main types of salivary gland cancer is surgical resection combined with adjuvant therapy in order to reduce failure rates. The rarity of the diagnosis and the few studies in the world literature affect the systemic therapeutic approach of these patients, constituting a challenge for the medical community.
Annals of clinical and laboratory science, 2015
Mucoepidermoid carcinoma of the lung is exceedingly rare. Our case involves a 58-year-old male who presented with shortness of breath, dysphagia, and weight loss. He denied ever smoking. Chest x-ray revealed trapped lung, and CT demonstrated a right bronchial mass. Diagnosis of lung carcinoma was made by bronchoscopic FNA biopsy. EGFR mutation was negative. Staging workup demonstrated evidence of advanced disease. Performance status was good, and it was decided to start chemotherapy and radiation for palliation. Lung carcinomas often present as an obstructing hilar mass. There are different histological grades that affect progression and survival. Though uncommon, metastatic spread has been previously reported. Studies have investigated the possible role of tyrosine kinase inhibitors in both EGFR-mutated and non-mutated cases. Unfortunately, there has been little consensus as to which therapies are most beneficial.
A Case of Pulmonary Mucoepidermoid Carcinoma Responding to Carboplatin and Paclitaxel
Japanese Journal of Clinical Oncology, 2014
A 59-year-old man was admitted to our hospital with dyspnea and cough. A large polypoid tumor was observed in the lower trachea and bronchoscopic polypectomy was performed using a snare to relieve symptoms. The tumor was diagnosed as a high grade mucoepidermoid carcinoma mainly by the histology of piecemeal specimens obtained by bronchoscopic resection. The primary lesion involved the trachea and the main bronchus, and there were multiple metastases in the lung. The patient was treated with the combination of carboplatin and paclitaxel. After four cycles of chemotherapy, the tumors were significantly reduced. He remains well without evidence of tumor progression for 25 months. This case suggests that the combination chemotherapy of carboplatin and paclitaxel can be an option for treatment of pulmonary mucoepidermoid carcinoma.
Mucoepidermoid tumor of the lung: CT appearance
Computerized Medical Imaging and Graphics, 1995
Mucoepidermoid tumor of the lung is a rare endobronchial neoplasm with a wide spectrum of appearance. We present a case report and describe the plain film and computed tomography (CT) findings.
Mucoepidermoid carcinoma of the lung mimicking a carcinoid tumor in presentation: a case report
Scholars Journal of Medical Case Reports, 2016
Mucoepidermoid carcinomas of the lung are endobronchial tumors which typically present with features of central bronchial obstruction mimicking carcinoid tumors in imaging and bronchoscopic findings. They are classified into low grade and high grade based on histological features. Very few cases are reported from worldwide and from India. We present here a case of primary mucoepidermoid carcinoma of the lung in a 17 year old male which mimicked a carcinoid tumor in presentation.
Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma
Modern Pathology, 2014
Pulmonary mucoepidermoid carcinoma is an uncommon but distinctive manifestation of mucoepidermoid carcinoma. Pulmonary mucoepidermoid carcinoma occurs in adults and children and can cause diagnostic problems, especially in small biopsies. Few studies have characterized the histologic and immunophenotypic features of pulmonary mucoepidermoid carcinoma. t(11;19)(q21;p13) is considered disease-defining for mucoepidermoid carcinoma; its significance in pulmonary mucoepidermoid carcinoma warrants further study. Forty three pulmonary mucoepidermoid carcinomas were re-reviewed and graded according to the Brandwein grading system for mucoepidermoid carcinoma. Four cases were excluded because of a split opinion between pathology report and re-review. These cases were negative for MAML2 rearrangement by FISH. TTF-1, napsin A, p40 and p63 immunostains were scored: 0 (negative), 1 (1-25% tumor cells), 2 (26-50%), 3 (51-75%) or 4 (475%). FISH to detect MAML2 rearrangement used a MAML2-11q21 break-apart probe. Thirty nine pulmonary mucoepidermoid carcinoma (4 low, 30 intermediate, 5 high grade) contained mucous, epidermoid and intermediate cells and lacked keratinization and in situ carcinoma of the overlying epithelium. All cases with available gross description (n ΒΌ 22) had a central/endo-or peribronchial location. All 25 cases tested for immunohistochemistry were positive (scores 1-4) for p63; 23 also expressed p40. In six cases, the p63 score was higher than p40. TTF-1 and napsin were uniformly negative in all 25 cases. MAML2 rearrangement was identified by FISH in each of the 24 cases tested (3 low, 19 intermediate, 2 high grade). Clinical history was available in 29 patients (15 men) (median age, 48 years) with follow-up in 24 (median, 8.4 years). Five patients died of unrelated causes; one developed metastatic pulmonary mucoepidermoid carcinoma. In conclusion, features helpful in distinguishing pulmonary mucoepidermoid carcinoma from other lung cancers include its central/endo-or peribronchial location together with the presence of mucous cells, p63 expression, lack of keratinization and MAML2 rearrangement. TTF-1 and napsin are typically not expressed.