Synthesis, Characterization and Antimicrobial properties of some transition metal complexes with NS-Chelating Schiff Base ligand incorporating thiophene and sulfonamide Moieties (original) (raw)
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Modern Chemistry, 2014
The Schiff bases, formed by condensation of 2-thiophenecarboxaldehyde with 2-aminothiophenol (LH) and propane-1,2-diamine (L 1), and their complexes of Ni(II), Cu(II), Zn(II) and Cd(II) have been prepared and characterized by elemental analysis, and magnetic and spectroscopic measurements. Infrared and NMR spectra of the complexes agree with the coordination to the central metal atom through the nitrogen of the azomethine (-HC=N-) group and the sulfur atom of the thiophene ring. Magnetic susceptibility data coupled with electronic suggest octahedral structure for the complexes. Conductance measurements suggest the non-electrolytic nature of the complexes. Stoichiometry of complexes has been suggested as [M(L) 2 ] and [ML 1 Cl 2 ]. The Schiff base and its metal chelates have been screened for their in vitro antibacterial activity against four human pathogenic bacteria. Ligands show moderately whereas some of metal chelates show highly antibacterial activity against them.
Asian Journal of Applied Chemistry Research
The metal (II) complexes, Na2[ML2] [M = Cu, Co, Ni, and Zn], of salicylaldehyde thiosemicarbazone (L) containing a trifunctional ONS-donor system have been synthesized and characterized on the basis of physicochemical data by elemental analysis, magnetic moment, molar conductance, and spectroscopic (electronic, IR and ESI-MS). The ligand functions as ONS tridentates producing octahedral complexes. All compounds showed significant antibacterial activity in different ranges against gram positive (Bacillus subtillus) and gram negative (Escherichia coli) bacteria.
The Open Bioactive Compounds Journal
Aim: Metal complexes of (E)-N-(4-(thiophen-2-ylmethyleneamino) phenylsulfonyl) acetamide (S.TH) Schiff bases derived from sulfacetamide (N-[4-(amino-phenyl) sulfonil] acetamide) and 2-thiophenecarboxaldehyde were synthesized and characterized. Methods and Results: The synthesized compositions have been characterized using different physico-chemical techniques. The investigation included elemental analysis, melting point measurements, proton NMR, UV spectroscopy, FT-IR, magnetic susceptibility, conductance measurements, mass spectral analysis, and inductively coupled plasma mass spectrometry (ICP-MS) for determining the concentrations of metal ions. The measured values for molar conductance indicated that the majority of the prepared complexes were nonelectrolytes. The biological activity of the prepared compositions has been investigated. Conclusion: Spectroscopic studies suggested that most of the complexes were coordinated in a regular octahedral arrangement where S.TH ligand and ...
2015
Co(II), Ni(II), Cu(II) and Cd(II) complexes of bidentate Schiff bases derived from the condensation of 4-amino-5-benzyl4H-1,2,4-triazoles-3-thione with pyridine-2-carboxyaldehyde, pyridine-3-carboxya- ldehyde and pyridine-4carboxyaldehyde were synthesized. The Schiff bases and their metal complexes were characterized by elemental and thermogravimetric analyses, spectral measurements (FT-IR, UV-Vis), molar conductance and magnetic moment measurements. Square planar (Cu(II) complexes), tetrahedral (Cd(II) complexes) and octahedral (Co(II) and Ni(II) complexes) geometries have been proposed. The presence of coordinated water in the metal complexes is confirmed by thermal analysis and IR data. The Schiff bases act as bidentate ligands coordinating via the azomethine nitrogen and thiolate sulfur atoms. The Schiff bases and their metal complexes have been screened for antimicrobial activity against six bacteria, namely Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus cereus, Microc...
International Journal of Pharma Research and Health Sciences, 2014
The Metal complexes of Co (II), Ni (II), Cu (II) and Hg (II) with a new Schiffbase derived from 2-Acetyl 5-chloro thiophene and o-Phenylenediamine in methanol are reported. The complexes have been characterized using chemical analysis, (IR, UV-VIS, H1-NMR), conductometric and magnetic data. According to these data, we propose an octahedral geometry for metal (II) complexes. The invitro antibacterial activities of the investigated complexes were evaluated against few microorganisms by well diffusion technique. It was found that the metal complexes have higher activity that the standard drugs. Antibacterial activity of the ligand and its complexes were studied against to gram positive acteria; Staphylococcus aureus and Bacillus subtilis and gram negative bacteria Salmonellatyphi and E. coli.
A new Schiff base ligand (N-pyridin-2-yl-4-[(pyridin-2-yl)methyl amino]benzene sulfonamide) (L) was prepared by the reaction between sulfapyridine and pyridine-2-aldehyde. The ligand is bidentate by coordinating through pyridinyl nitrogen and azomethine nitrogen atom with Co(II), Ni(II), Cu(II), Zn(II) and Mn(II) chlorides. The complexes were synthesized and characterized by elemental analysis, molar conductance, magnetic moment, IR, H 1 NMR and electronic spectral data. These complexes were screened in vitro antibacterial activity against the test microorganisms Staphylococcus aureus, Pseudomonas aeruginosa and fungi Candida albicans and Aspergillus niger. The results of these studies revealed that all complexes exhibit significant to moderate antimicrobial activity. aldehydes like indole-2-aldehyde and pyrrole-2-aldehyde are coupled with sulfa drugs the resulting compound sulfadrugimine can act as an effective antibacterial agent 10 . In the present investigation an attempt has been made to synthesize Schiff base by coupling pyridine-2-aldehyde and sulfapyridine and also its complexes with various first row transition metal chlorides.
Pakistan journal of pharmaceutical sciences, 2019
A new series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes with a novel Schiff base were synthesized by the condensation of sulphadizine and thiophene-2-carbaldehyde.The ligand and its complexes were characterized by using diverse instrumental procedures like microanalysis, thermo gravimetric examination and spectroscopy. The integrated ligand and its metal complexes were subjected to antibacterial studies. These studies demonstrated the enhanced activity of metal complexes against reported microbes with respect to the Schiff base.
International Journal of Health Sciences (IJHS), 2022
New Azo-Schiff base ligand [4-((E)-(2hydroxyphenyl)diazenyl)-3-(((1E,2E)-2-((2-((E)-(2hydroxyphenyl)diazenyl)-5-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)imino)-1,2-diphenylethylidene)amino)-N-(pyrimidin-2-yl)benzenesulfonamide] (4HDPS) was primed. Three chelate complexes have correspondingly been equipped by reacting this ligand (4HDPS) with the metal ions Co (II), Ni (II) and Cu (II). (UV-Vis) electronic spectra of complexes showed bathchromic shift, as compared with that of free ligand .The Mass Spectrum and 1HNMR Spectrum of the free ligand has been taken and the FTIR spectrums of the Ligand and its chelating complexes have been investigated. This may specify that coordination among the metal ions and the equipped ligand takes place .The conductivity and magnetic measurements, Elemental micro analysis and the percentage of metal ions were determined. Based on these consequences, the proposed geometrical structures of the equipped complexes of Co(II),Ni(II) and Cu(II).ions are octahedral with mole ratio (M:L) was (1:1) for all prepared complexes while the conductivity measurements shows non-electrical properties. The final stage involved the study of the biological activity of prepared component to two type of pathogenic bacteria: (G+) Staph. Aureus and Escherichia coli (G-) using Well diffusion methods. Three different concentration were tested (100, 500, 1000) ppm in Ethanol Absolute (99%) as a 5525 solvent. The prepared compounds showed different results (high, moderate, low, and inactive). While the new prepare Azo-Schiff (4HDPS) showed less inhibition growth against both type of bacteria in comparison with its complexes. Also, the metallic ligand complexes showed more inhibition activity against Gram positive than Gram negative.
A new mixed thia-aza-oxo macrocycle schiff base viz., 1,10-dithia-3, 8,12,17-tetraoxo-4,7,13,16tetraazacyclooctadecane with a series of transition metals Cu(II), Co(II), Ni(II) and Mn(II) has been synthesised by the [2+2] condensation of thiodiglycolic acid and ethylenediamine. Different techniques like FTIR, 1 H NMR, ESI MS, UV-Vis spectroscopy, conductivity and magnetic measurements were used to investigate the structural features of the synthesised compounds. Electronic absorption and IR spectra indicate octahedral geometry for chloro and nitrato complexes and square geometry for all sulphato complexes. The redox behaviour was investigated by cyclic voltammetry and show metal centered reduction process for all complexes. The reduction and oxidation potential depends on the structure and conformation of the central atom in the coordination compounds. The complexes of Cu(II) show both oxidation and reduction process. These metal complexes were also tested for their in vitro antimicrobial activities against some bacterial and fungal strains to assess their inhibiting potential and the activities shown by these complexes were compared with standard drugs.
Earthline Journal of Chemical Sciences
Schiff base ligand derived from condensation of 2-aminothiophenol and 2-thiophene carboxyldehy was synthesized and used for the preparation of Cr(II), Mn(II) and Co(II), complexes. The synthesized ligand and complexes were analyzed by decomposition temperature, solubility, magnetic susceptibility, molar conductance and infrared spectra. The decomposition temperatures of the complexes are in the range of 128-221ºC. Molar conductance values are in the range of 6.07-9.10 ohm-1cm2mol-1. New bands appeared in the IR spectra of the complexes in the range of 511-552 cm-1 and 438-473 cm-1 which indicate υ(M - N) and υ(M - S) vibrations respectively. Magnetic susceptibility measurement indicated that all complexes are paramagnetic while solubility test revealed that all complexes and ligand are soluble in DMSO. The analytical data show the formation of 2:1 metal to ligand ratio for all complexes and suggested the formula [ML2].nH2O.The ligand and metal chelates have been studied for microbia...