Histoplasmosis mimicking childhood non-Hodgkin lymphoma (original) (raw)
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Purulent Pleurisy Revealing Lymphoblastic Lymphoma Type T: A Pediatric Case Report
Open Journal of Pediatrics
Lymphoma is a very common cancer in the pediatric population, and its modes of revelation are very variable. Case report: A 7-year-old patient was admitted for purulent pleurisy, whose cytological study of the pleural fluid isolated lymphoblastic cells in favor of a T-type lymphoblastic lymphoma, a very rare mode of revelation in current practice. Conclusion: Pediatric lymphoma takes on different aspects, and it is important to look for it systematically in order to ensure adequate management.
Revista de Chimie
The goal of pleural fluid assessment is to establish with certainty its etiology and major challenge is the etiologic diagnosis precocity. Pleural effusion as the first and the only event in the onset of non-Hodgkin lymphoma is atypically in the absence of other signs and symptoms. Follicular lymphoma (FL) also called indolent lymphoma the most frequent is a low-grade non-Hodgkin’s lymphoma (NHL). In patients with indolent lymphoma affecting the pleura and pericardium is atypical and appears only in aggressive forms, so the onset with pleural effusion is unusual. Serous effusions may occur from onset or during evolution of various subtypes of T cell originated lymphomas or high-grade B cell lymphomas. Primary pleural lymphomas (PPL) have been described at patients with human immunodeficiency virus infection; tuberculosis complicated with chronic pyothorax or after exposure to asbestos. Compared to other similar cases previously reported in the medical literature, the novelty of this...
journal of medical science and clinical research, 2017
Context: Diagnosis of lymphoma constitutes a difficult task in context to subtyping. Accurate diagnosis is essential because the treatment options, responses to therapy and prognosis vary widely depending on the diagnosis. However to make a definitive diagnosis of a lymphoma based solely on the H & E light microscopy, findings may be exceedingly difficult because of frequent absence of distinguishing features. IHC represents a tool that can provide a clear distinction among the different types of lymphoma. The purpose of IHC is to categorize the patient in order to ensure appropriate and specific treatment, as well as to identify tumours at higher risk of recurrence and fatal outcomes. Aims: To study histomorphology of different lymphomas and correlation of it with immunohistochemical findings. Settings and Design: The present study is a retrospective as well as prospective study of lymphoma cases diagnosed based on routine histopathology as well as correlation of it with immunohistochemistry in surgical pathology section of the Central Diagnostic Laboratory, Shree Krishna Hospital, Karamsad from September 2010 to August 2015. Materials and Methods: A detail clinical history, nature of specimen and other investigations were noted in the proforma. Macroscopic and microscopic findings or any incidental findings were documented in the final report. Results: Total 47 cases of lymphoma were diagnosed in study period among them 42 cases were of B cell lymphoma and 7 cases were of T cell lymphoma. All B cell lymphoma were positive immunihistochemically for CD 20 and LCA. Out of 47 cases 25(53.19%) were of lymphoid origin and 22(46.81%) were of extralymphoid site. Conclusion: From this study it was concluded that: In all the cases diagnosis of hematoxyllin and eosin stained sections were correlated with immunohistochemical findings Non Hodgkin's Lymphoma were most common than Hodgkin's lymphoma Lymphnodes are the most common site of origin.
Primary lymphomas of the lung: morphological, immunohistochemical and clinical features
Histopathology, 1990
Primary lymphomas of the lung: morphological, immunohistochemical and clinical features Sixty-two cases of primary malignant lymphoma of the lung were investigated. Fifty-eight lymphomas were of Band two of T-cell type. Two cases of high-grade lymphoma could not be further classified. The largest group (43 cases) consisted of low-grade B-cell lymphoma of the bronchus-associated lymphoid tissue. These showed features similar to low-grade B-cell lymphomas of the mucosa-associated lymphoid tissue of the stomach. The low-grade lymphomas showed a peak occurrence in the sixth decade, the high-grade lymphomas in the seventh decade. Males predominated slightly. Threequarters of the patients with low-grade B-cell lymphoma of the bronchus-associated lymphoid tissue showed solitary or multiple sharply defined nodules of the lung. The prognosis of the B-cell-derived lung lymphomas without constitutional symptoms was relatively favourable, regardless of whether they were of low-or highgrade malignancy, whereas patients with constitutional symptoms and the two patients with T-cell lymphomas showed a bad prognosis. However, recurrences and metastases in the lung, stomach, lymph nodes and salivary glands were seen in about 46% of the cases of low-grade B-cell lymphoma of the bronchus-associated lymphoid tissue.
Primary pleural non-Hodgkin lymphoma in a child—an exceedingly rare disease
Journal of Pediatric Surgery, 2012
Primary pleural lymphomas are very rare. Two types are described in the literature: primary effusion lymphoma, in the setting of human immunodeficiency virus infection, and pyothoraxassociated lymphomas, with a strong Epstein-Barr virus association. We report a rare case of a primary pleural lymphoma in a 12-year-old immunocompetent girl who presented with a hemorrhagic pleural effusion and had plaque-like thickening of the pleura. The histologic and immunophenotypic findings conformed to that of a diffuse large B-cell lymphoma (CD20 positive).
Primary Pleural Lymphoma: Case Report
British Journal of Healthcare and Medical Research, 2023
We report a case of a 70-year-old female with a history of prolonged exposure to biomass during childhood, non-smoker and no history of exposure to people with tuberculosis who presented with progressive dyspnea. Chest CT showed circumferential and nodular suitable pleural thickening with involvement of the mediastinal pleura and ipsilateral pleural effusion. An ultrasound-guided pleural biopsy was performed with a Trucut needle. The Histopathology result of the pleural biopsy determined an infiltration due to non-Hodkin lymphoma of lineage B. Immunohistochemistry CD20 positive, CD3 Positive. This case is thought to be a very rare case of primary malignant lymphoma arising in the pleura without a history of chronic pleural inflammation or immunocompromise.
Clonality and phenotyping analysis of alveolar lymphocytes is suggestive of pulmonary MALT lymphoma
Respiratory Medicine, 2011
Mucosa-associated lymphoid tissue (MALT) lymphoma, a low-grade B-cell extranodal lymphoma, is the most frequent subset of primary pulmonary lymphoma (PPL). It often associates with connective tissue disease (CTD). We aimed to evaluate the impact of concomitant CTD on diagnostic value of flow cytometry and genetic clonality analyses for the diagnostic of MALT lymphoma. All chest disease and pathology departments of teaching hospitals in Paris were contacted to identify patients with a histological diagnosis of PPL of the MALT subtype with or without associated CTD. We identified 44 patients in the lymphoma group; 11 had a CTD and were matched to 11 patients with CTD but without lymphoma. Results of BAL analyses of MALT-PPL showed normal cellularity (370 cells/mm(3) [range 21-2300]) but increased proportion of lymphocytes (31.5% [80-2]) of the B-cell subtype (20% [1-88]). A B-cell clone was detected in 82% of cases, and specificity of clonality was 90%. Interestingly, BAL analysis results different by presence or not of a CTD. The frequency of B lymphocyte alveolitis was significantly greater in MALT patients without than with CTD (34% vs 6.5%, p = 0.007). However, BAL results for patients with CTD did not differ between those with and without lymphoma. BAL results may be highly suggestive of pulmonary MALT lymphoma. The proportion of B-cells may vary depending on the presence of an associated CTD, but clonality analyses remained informative for the diagnostic of MALT lymphoma.
Pulmonary Histoplasmosis Mimicking Metastatic Lung Cancer: A Case Report
Diagnostics
Histoplasmosis is a well-known endemic fungal infection but experience in non-endemic regions is often limited, which may lead to delayed diagnosis and extensive testing. The diagnosis can be especially challenging, typically when the disease first presents with pulmonary nodules accompanied by hilar and mediastinal lymphadenopathy, suggesting a much more common malignant disease. In this situation, a greater FDG uptake in draining lymph nodes in comparison with the associated lung nodule seen in [18F]FDG-PET/CT, the so-called “flip-flop fungus” sign, can help to orientate further diagnostic measures. We report a case of a 56-year-old woman living in Switzerland, a non-endemic region, whose diagnosis of imported histoplasmosis was delayed since the findings had been initially misinterpreted as pulmonary malignancy. Further, histological workup was inconclusive due to lack of specific fungal staining, leading to ineffective treatment and non-resolving disease. This paper intends to h...