The specificity of JAK3 kinase inhibitors (original) (raw)
Kinase Inhibition — A New Approach to the Treatment of Rheumatoid Arthritis
David Fox
New England Journal of Medicine, 2012
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Evaluation of JAK3 biology in autoimmune disease using a highly selective, irreversible JAK3 inhibitor
Lauren Dorosh
The Journal of pharmacology and experimental therapeutics, 2017
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Selective JAK inhibitors
Joy, Yu-Yi Chu
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Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes
Joel Kremer
Best Practice & Research Clinical Rheumatology, 2010
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Clinical efficacy of launched JAK inhibitors in rheumatoid arthritis
Peter Taylor
Rheumatology, 2019
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Therapeutic treatment of a novel selective JAK3/JAK1/TBK1 inhibitor, CS12192, in rat and mouse models of rheumatoid arthritis
Lijun Xin
International Immunopharmacology, 2019
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JAK-Inhibitors for the Treatment of Rheumatoid Arthritis: A Focus on the Present and an Outlook on the Future
Francesco Scaglione
Biomolecules, 2020
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Recent progress and perspective in JAK inhibitors for rheumatoid arthritis: from bench to bedside
Yoshiya Tanaka
Journal of Biochemistry, 2015
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Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection
Paul Changelian
Journal of Medicinal Chemistry, 2010
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Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases
R. Galien, E. van der Aar, Gerben A E van 't Klooster, Steve De Vos, Katja Conrath
The Journal of Immunology, 2013
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Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050
Swamy Yeleswaram
The Journal of Immunology, 2010
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Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice
Martin Hegen, Rustem Krykbaev
Arthritis & Rheumatism, 2010
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Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis
John Tokarski
ACS Medicinal Chemistry Letters, 2019
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Janus Kinase Enzyme (Jak) Inhibitors and Rheumatoid Arthritis: A Review of the Literature
hana morrissey
International Journal of Current Pharmaceutical Research
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Developments with investigational Janus kinase inhibitors for rheumatoid arthritis
Patrice Decker
Expert Opinion on Investigational Drugs, 2016
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Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol
jonathan george
Journal of Biological Chemistry, 2014
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The Novel JAK-3 Inhibitor CP-690550 Is a Potent Immunosuppressive Agent in Various Murine Models
Paul Changelian
American Journal of Transplantation, 2004
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Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
Nandini Kishore
Journal of Inflammation, 2010
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Phase I evaluation of XL019, an oral, potent, and selective JAK2 inhibitor
Lubomir Sokol
Leukemia Research, 2014
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A Phase 2b Study of ABT-494, a Selective JAK1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti-TNF Therapy
Paul Emery
Arthritis & rheumatology (Hoboken, N.J.), 2016
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Kinase inhibitors: A new tool for the treatment of rheumatoid arthritis
George Kalliolias
Clinical Immunology, 2013
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Jak Inhibitors for Treatment of Autoimmune Diseases: Lessons from Systemic Sclerosis and Systemic Lupus Erythematosus
Przemyslaw Kotyla
Pharmaceuticals
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In vitro and in vivo characterization of SGI-1252, a small molecule inhibitor of JAK2
Kausar Ahmed
Experimental Hematology, 2011
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The design of a Janus Kinase 3 (JAK3) specific inhibitor 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) allowing for the interrogation of JAK3 signaling in humans
Mai Shihah binti Haji Abdullah abdullah
Journal of medicinal chemistry, 2017
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Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors
Anna Yarilina
Arthritis & Rheumatism, 2012
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Design of novel JAK3 Inhibitors towards Rheumatoid Arthritis using molecular docking analysis
Dr Shreshtha sharma
Bioinformation, 2019
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Pharmacophore and Virtual Screening of JAK3 inhibitors
Santhi Natchimuthu
Bioinformation, 2014
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Regulation of macrophage-mediated chronic inflammation by JAK inhibitors
Anna Yarilina
Arthritis Research & Therapy, 2012
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