original ) (raw )Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1, 2, 5, 6-tetrahydropyridine
Ritik Kumar
Life sciences, 1985
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Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria
Rona Ramsay
The Journal of Biological Chemistry, 1986
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Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP
Rona Ramsay
Life sciences, 1986
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Mechanism of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP+), the toxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Rona Ramsay
Toxicology, 1988
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Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism
Rona Ramsay
Biochemical and Biophysical Research Communications, 1986
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Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode
Gavin Davey
Biochemical Journal, 1992
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The inhibition site of MPP+, the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine is near the Q-binding site of NADH dehydrogenase
Rona Ramsay
Archives of Biochemistry and Biophysics, 1987
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1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), its metabolite cyperquat (MPP+) and energy transduction in mitochondria from rat striatum and liver
Jay Thakar
Progress in Neuro-psychopharmacology & Biological Psychiatry, 1988
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Dopaminergic Neurotoxicity In Vivo and Inhibition of Mitochondrial Respiration In Vitro by Possible Endogenous Pyridinium-Like Substances
Charles Hoppel
Journal of Neurochemistry, 1991
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Biochemical mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity
James Adams
Biochemical Pharmacology, 1991
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Potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium: Selective toxicity of 1-methyl-4-(4′-acetamidophenyl)-pyridinium and 1-methyl-4-cyclohexylpyridinium for dopaminergic neurons in culture
Simon Efange
Experimental Neurology, 1990
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine inhibits proton motive force in energized liver mitochondria
yogendra singh
Archives of Biochemistry and Biophysics, 1989
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Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria
Michel Baudry
Brain Research, 2003
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Measurement of mitochondrial respiration in permeabilized murine neuroblastoma (N-2α) cells, a simple and rapid in situ assay to investigate mitochondrial toxins
Japie Mienie
Journal of Biochemical and Biophysical Methods, 2005
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Chemical oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its in vivo metabolism in rat brain and liver
pramod arora
Biochemical and Biophysical Research Communications, 1988
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Variable toxicological response to the loss of OXPHOS through 1-methyl-4-phenylpyridinium-induced mitochondrial damage and anoxia in diverse neural immortal cell lines
Youssef Soliman , Elizabeth Mazzio , Karam Soliman
Cell Biology and Toxicology, 2010
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Similar Inhibition of Mitochondrial Respiration by 1Methyl4-Phenyl-Pyridinium (MPP + ) and by a Unique N-Methylated Beta-Carboline Analogue, 2,9?Dimethyl?Norharman (2,9Me 2 NH
Edward Neafsey
Annals of The New York Academy of Sciences, 1992
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MPTP as a Mitochondrial Neurotoxic Model of Parkinson's Disease
Celine Perier
Journal of Bioenergetics and Biomembranes, 2000
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Mitochondria as a Target for Neurotoxins and Neuroprotective Agents
elena kireeva
Annals of The New York Academy of Sciences, 2003
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Inhibition of complex I by hydrophobic analogues of N -methyl-4-phenylpyridinium (MPP+) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport particles
Rona Ramsay
Biochemical Journal, 1995
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Mitochondria Targeted Peptides Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Neurotoxicity
Hazel Szeto
Antioxidants & Redox Signaling, 2009
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Coenzyme Q, peroxidation and cytochrome oxidase features after Parkinson's-like disease by MPTP toxicity in intra-synaptic and non-synaptic mitochondria fromMacaca Fascicularis cerebral cortex and hippocampus: action of dihydroergocriptine
Gian Paolo Littarru
Neurochemical Research, 1996
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Correlation between 1-methyl-4-phenylpyridinium ion (MPP+) levels, ascorbic acid oxidation and glutathione levels in the striatal synaptosomes of the 1-methyl-4-phenyl-1,2,3-6-tetrahydropyridine (MPTP)-treated rat
L. Fresu
Neuroscience Letters, 1993
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The Parkinsonism-inducing Drug 1-Methyl-4-phenylpyridinium Triggers Intracellular Dopamine Oxidation
Julie Lotharius
Journal of Biological Chemistry, 2000
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Evidence that the inhibition sites of the neurotoxic amine 1-methyl-4-phenylpyridinium (MPP+) and of the respiratory chain inhibitor piericidin A are the same
Rona Ramsay
Biochemical Journal, 1991
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The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity
Julie Lotharius
The Journal of biological chemistry, 2000
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Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Ariel Deutch , Jeffrey Franklin
Biochemical and Biophysical Research Communications, 2003
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Inhibition of NADH oxidation by pyridine derivatives
Rona Ramsay
Biochemical and Biophysical Research Communications, 1987
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Effect of serotonergic, corticostriatal and kainic acid lesions on the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine (MPTP) in mice
Anat Tsur
Brain Research, 1986
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