Analysis of histopathological spectrum of intracranial central nervous system tumours in a tertiary care hospital (original) (raw)
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Spectrum of Central Nervous System Tumours-Histopathological Study of 80 Cases at a Single Center
2020
Introduction: Recent studies showed an increase in the incidence of central nervous system (CNS) tumours. Current research aimed to study the histopathological spectrum of CNS tumors irrespective of age in single tertiary care center for the last two years. Material and methods: The H and E stained histopathological slides of biopsy of CNS tumors received from September 1st 2018 to August 31st 2020 were retrieved. The slides were examined and in necessary situations immunohistochemistry was carried out and the diagnosed cases were grouped based on WHO 2007 classification. Results: Among the 80 CNS tumors, the majority (76 cases, 95%) presented as space occupying lesion in the brain and remaining 5% (4 cases) were intra-spinal tumors. We found that Tumors of neuroepithelial tissue (40 cases, 50%) was the most common entity followed by the c (28 cases, 35%), followed by metastatic tumors (5 cases, 6.25%). Conclusion: The common occurrence of neuroepithelial tissue tumors and neuroepit...
Distribution of various CNS tumors in a tertiary care hospital: Ten year retrospective study
International journal of applied research, 2018
Background: CNS tumors, though not the leading cause of cancer cases, causes significant number of cancer deaths. Five years survival in most of patients with CNS tumors is less than 20%. With the advent of newer diagnostic modalities even in developing countries like India many new cases were diagnosed every year. Due to incomplete registration of cases in India exact frequency is difficult to estimate. Hospital based study can be a good resource to estimate the disease burden. Objectives: To study the frequency with age and sex distribution of various CNS tumors. Materials and Methods: It was a ten year retrospective study conducted in the Department of Pathology, Gajra Raja Medical College, Gwalior (M.P.) from January 2007 to December 2016. 1620 cases of CNS neoplasms were collected. Diagnosis were done on the basis of histopathology. Categorisation according to various types with their age and sex distribution was done from these datas. Result: In adults most common tumors were ...
Journal of Evidence Based Medicine and Healthcare, 2016
BACKGROUND Tumours of central nervous system (CNS) are of varied histogenesis and show divergent lines of differentiation and morphological features. These tumours show specific predilection for age and sex groups, more commonly than of tumours of other systems. Though tumours of glial tissue are more common, other tumours of neural, ependymal and meningeal origin are not uncommon. Metastatic disease is the common encounter in elderly. Tumour diagnosis is not always straight forward as many non-neoplastic lesions and reactive proliferations mimic tumours. Immunohistochemistry may help in problematic cases and thus can be used as an adjuvant tool in the diagnosis of such cases in addition to the routine histopathological staining methods. An accurate histological diagnosis is of extreme importance in these sites as exact diagnosis helps in proper management and favourable clinical outcome. MATERIAL & METHODS This study is on a retrospective and prospective basis in our institution from January 2011 to January, 2016. Our institute is a tertiary care center attached to a medical college catering to the needs of a rural based population. During this period, a total of 717 central nervous system tumour specimens were received and diagnosed based on examination of Haematoxylin and Eosin stained sections of formalin fixed and paraffin embedded specimens. Immunohistochemical markers (IHC) were applied in selective cases for an accurate diagnosis and a number of rare cases were diagnosed based on morphology and IHC marker studies. RESULTS Age and sex incidence and anatomic distribution of various tumours were studied. In adults, meningiomas occurred most frequently in the present study followed by nerve sheath tumours, astrocytomas, metastatic deposits, glioblastomas and pituitary adenomas. Embryonal tumours occurred frequently in children. Other rare tumours identified are amyloidogenic pituitary adenoma, central neurocytoma, glioneuronal tumour with neuropil-like islands, ganglioglioma, large cell medulloblastoma, rhabdoid and secretory meningioma, immature teratoma and gliosarcoma. Grading of the tumours was done according to the revised World Health Organization criteria. CONCLUSION In this study, we discuss the process of establishing accurately the diagnosis of central nervous system tumours including spinal tumours, with emphasis on rare tumours encountered and how IHC helped in the diagnosis.
Clinicopathological Correlation of CNS Tumours
https://www.ijrrjournal.com/IJRR\_Vol.6\_Issue.3\_March2019/Abstract\_IJRR0032.html, 2019
Central nervous system (CNS) tumours constitute 1-2% of all neoplasms. They represent the second most common and overall the most common solid tumour of paediatric age group. Approximately 25% of all cancer related mortalities in paediatric population can occur because of CNS tumours. Aim of the study to determine the incidence of various CNS tumours and correlate histopathological diagnosis with clinical diagnosis and frozen section in selective cases. This is a retrospective and prospective study evaluating 60 patients of CNS tumours in a tertiary level hospital in Navi Mumbai. Fresh specimens obtained in intraoperative cases and postoperatively in fixative were examined and stained. Study of clinicopathological correlation gives the idea of distribution of brain tumour and demonstrates the changes in tumour spectrum in our population. High accuracy in frozen section diagnosis and its use can help in therapeutic approach which results in reduction in mortality and morbidity.
Spectrum of Central Nervous System Tumors-A Four Year Study In A Tertiary Care Center
2018
Introduction: Tumours of central nervous system constitute 1%-2% of tumours in adults. Few studies are available from India which show a lower incidence of brain tumours compared to the developed countries. Not much is known about the epidemiology of brain tumours in South Indian population. Aim: To identify the age and gender distribution, different histological types and grades of brain tumours according to 2016 WHO classification. Material and Methods: A retrospective study of 122 cases of brain tumours over a period of four years was done. We reclassified and graded the tumors based on 2016 WHO classification. Age and gender distribution, clinical presentation, site of tumour and histopathologic patterns with grade were noted and the data was analysed. Results: Predominant age group affected was between 40-50 years, with a male to female ratio of 1.14:1. Diffuse Astrocytic tumors were the most common type, followed by Meningiomas. Majority of cases were of WHO grade II and invol...
Spectrum of intracranial tumours in a tertiary health care facility: our findings
Pan African Medical Journal, 2015
Introduction: primary brain tumours are uncommon with an annual incidence of 5-10/100000. This study has attempted to analyse the histological pattern of intracranial tumours seen in our centre. Methods: a retrospective study of cases of intracranial tumours seen was conducted over a period of 5 years ie from January 2008 to December 2012. All the slides were reviewed. The age, sex, diagnosis using the WHO grading and the histological subtypes were recorded. Data were analysed using the (SPSS) Software version 17. Results: altogether, 56 cases of intracranial tumours were seen out of a total of 12,610biopsies representing 0.004% .The male to female ratio (M: F) was approximately 1:1.1The mean age of the patients was 36 ± 20.35 (range, 2 to 85). Astrocytomas accounted for 30% (17)while 29% (16) had Meningioma.Medulloblastoma accounted for 18%.(10).Of the cases of Gliomas, majority(52%) fell under WHO grade II. (38%)of the Meningioma were of the mixed type while 25% had transitional type. Conclusion: astrocytomas was the commonest brain tumour.These patterns corroboratedmost studies that have been done.Metastasis to the brain was however, not seen in this study.
Journal of Ayub Medical College, Abbottabad : JAMC
The incidence of central nervous system (CNS) tumours has rapidly increased over the past few years. There is no accurate nationwide CNS tumour epidemiology in Pakistan that makes policy making for tumour screening and early treatment difficult. The purpose of this study was to provide the spectrum of CNS tumours in a premier diagnostic and referral centre of Pakistan. This cross-sectional study was carried out at Histopathology Department, Armed Forces Institute of Pathology over a period of 5 years. A total of 761 cases patients who were diagnosed with CNS tumours on histopathology, both benign and malignant, belonging to both genders, between the ages of 1-85 years, from 11.2009 to 31.12.2013 were included in the study. Seven CNS tumour categories were as follows; tumours of neuroepithelial tissue (56.0%), tumours of the meninges (28.3%), tumour of the sellar region (2.6%), germ cell tumour (0.1), tumour of cranial and paraspinal nerves (5.4%), lymphomas and haematopoietic neopla...
Spectrum of Brain Tumors in a Tertiary Care Hospital: A 5 Years Study
Background-Tumor epidemiology is a significant part in case of intracranial tumor studies. Here, we discuss the features of intracranial tumor pathology in single centre. Aims and Objective-To analyze the age,sex and site wise distribution of different histological pattern of intracranial tumors seen in our centre. Materials and Methods-It is a retrospective study of cases of intracranial tumors seen over a period of 5 years .Altogether 160 CNS specimens were fixed in 10% Formalin and processed in automatic tissue processor. Routine Hematoxylin and Eosin stain and special stains were done and examined under the light microscope. The diagnosis is given on the basis of age,sex distribution using the WHO grading and the histological subtypes.Results-Out of total 160 cases of intracranial tumor 86 cases were of meningioma (53.75%). 30 cases were of astrocytoma (18.75%).13 cases are of pituitary adenoma (8.125%) .11 cases were of schwannoma (6.875).5 cases were of glioblastoma grade 4 (3.125%).5 cases were of oligodendroglioma grade 2 (3.125%).2 cases were of each metastatic carcinoma, ependymoma,cerebellar hemangioblastoma and tuberculoma (1.25%).1 case of each central neurocytoma and craniopharyngioma (0.625%).In this study meningioma is the most common intracranial tumor followed by astrocytoma.Conclusion-Meningiomas are commonest tumor and comprise more than half of all operated CNS tumors in our setup, followed by astrocytomas.Meningothelial Meningioma is the most common subtype.This study can help in observing CNS tumor trends and changing patterns.
Characteristic of Central Nervous System Tumours from 2011-2015: A Single Institution Study
Medicinus
Background: Central nervous system (CNS) tumours affect the quality of life of patients since its neurological deficits. Data from Globocan 2012 reveals that there are 256,000 cases of CNS tumour. Epidemiology of the CNS tumours is very important for diagnosis and treatment, but data in Indonesia is still not fully reported.Objective: The aim of this study was to determine the exact amount of the incidence, histologic type of the tumour and the characteristic of patient in our institution.Methods: This is an observational study, all pathology report of CNS tumours that underwent surgery at Siloam Hospitals Lippo Village from 2011 until 2015. We classified based on gender, age, location of the tumour, and the histologic type according to WHO Classification of CNS tumour 2007.Results and Discussion: There were 913 patients of CNS tumours from 2011 until 2015. The most common tumours were meningioma (32.96%) followed by glioma (21.35%) and pituitary adenoma (16.10%). In meningioma, mos...
Retrospective histological analysis of CNS tumors - A 5 year study
International Journal of Medical Science and Public Health, 2014
Background: Cancers of the central nervous system (CNS) are considered to be among the most notorious of all cancers. The brain and spinal cord are complex & delicate organs that control the higher functions, the peripheral nervous system, and many of the voluntary and involuntary systems of the body. It has been found that about 1/3 of all cancers metastasize to the brain. Low-grade tumors have been found over time to progress to high grade tumors. Aims & Objectives: The objective of this article is to provide a current overview of the descriptive epidemiology of central nervous system tumors in our hospital set up. Our target was to study incidence of various lesion in light of WHO classification (2007) & study relevant statistics. Materials and Methods: A total of 65 cases of CNS tumors were retrieved from the archives of the Department of Pathology, M.G.M. Medical College, Indore from May 2009 to May 2014. The diagnoses in all the cases were made on hematoxylin & eosin stained slides of processed tissue. Results: In our study, meningioma was the most common lesion followed by astrocytoma. Out of total 65 cases, we came across 27 cases of meningioma and Astrocytoma was in 16 cases. 5 cases of ependymomas were seen. Conclusion: Males are at much higher risk of developing CNS lesion in comparison to females. WHO Grade I lesions were more common in our institutional set up. Astrocytic WHO Grade III lesion was more common in comparison to Grade I lesion indicating need for imaging & neurology consultation at grass root level.