Formulation and Characterization of Polymeric Cross-Linked Hydrogel Patches for Topical Delivery of Antibiotic for Healing Wound Infections (original) (raw)
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e-Polymers
This research aimed to prepare and characterize a new type of polymeric cross-linked topical hydrogel patches for the treatment of wound infections. The free radical polymerization method was used to prepare the topical hydrogel patches by utilizing natural polymers, i.e., agarose and gelatin. These natural polymers were chemically cross-linked with monomer (acrylic acid) using ammonium persulfate as an initiator via the cross-linker N,N methylene bisacrylamide. An antibiotic, i.e., gentamicin sulfate was loaded into a designed polymeric system. The polymeric cross-linked topical hydrogel patches were made in a spherical shape, which was revealed to be stable and elastic. Fourier transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry, thermogravimetric analysis, and X-ray powder diffraction investigation were used to characterize the topical hydrogel patches. Polymeric cross-linked hydrogel patches were evaluated for their sol–gel analysis, ...
Formulation and evaluation of Hydrogel for wound healing
The hydrogels are 3-D networks which consists of physically or chemically cross-linked bonds of hydrophilic polymers. The insoluble hydrophilic structures designate a potential to absorb wound exudates and allows oxygen diffusion to fasten healing process. The aim of the present study is to formulate and evaluate a hydrogel of Neomycin sulfate for wound healing. Neomycin sulphate is an antibiotic used to treat bacterial skin infections. It is good effective in treatment of infected cuts, wounds, ruptured tissue and fatigue as well as minor burns. The neomycin sulfate hydrogel for wound healing topical application was formulated using guar gum and Carbopol-940 and evaluation were performed. Proper selection of polymers and their proportions is a prerequisite for designing and developing a transdermal drug delivery system. The formulated hydrogel showed good homogeneity, good stability and better drug release rates when compared to marketed formulation.
2019
Background: This study aims to develop a hydrogel containing gentamicin and ethanol extract of Tetracarpidium conophorum (EETC) impregnated gauze to be used as potential wound dressing to promote wound healing via inhibition of growth of microorganisms by gentamicin, and removal of products of inflammation via high radical-scavenging capacity to facilitate wound healing. Method: A modification of free radical initial polymerisation of the alkyl acrylate polymer was utilised to formulate the gentamicin hydrogel with triethanolamine as the cross linker. The hydrogel membranes were evaluated via Fourier transform infrared and the formulations were assessed for swelling index, skin irritancy and in-vitro release of the gentamicin where kinetics were applied to study drug-release kinetics. Results: In-vivo wound healing tests and histopathology were performed with Carbopol® Ultrez 21 exhibiting higher swelling index (97.6–99.6%) due to the availability of more alkyl acrylate polymer chai...
Polymers
The treatment of successive skin wounds necessitates meticulous medical procedures. In the care and treatment of skin wounds, hydrogels produced from natural polymers with controlled drug release play a crucial role. Arabinoxylan is a well-known and widely available biological macromolecule. We produced various formulations of blended composite hydrogels (BCHs) from arabinoxylan (ARX), carrageenan (CG), and reduced graphene oxide (rGO) using and cross-linked them with an optimal amount of tetraethyl orthosilicate (TEOS). The structural, morphological, and mechanical behavior of the BCHs samples were determined using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscope (SEM), mechanical testing, and wetting, respectively. The swelling and degradation assays were performed in phosphate-buffered saline (PBS) solution and aqueous media. Maximum swelling was observed at pH 7 and the least swelling in basic pH regions. All composite hydrogels were found to be hemo...
Journal of Drug Delivery and Therapeutics, 2017
Present article describes the synthesis, characterization, swelling and drug release behaviour of carbopol-cl-poly (2-hydroxyethylmethacrylate) hydrogel wound dressings. These polymers were characterized by, scanning electron microscopy, atomic force microscopy, Fourier transform infrared spectroscopy, 13C nuclear magnetic resonance spectroscopy, X-ray diffraction study, thermal degradation studies, and differential scanning calorimetry. The hydrogel film possessed smooth, homogenous surface with average surface roughness 0.570 nm. Swelling of the hydrogels increased with increase in pH of swelling medium. The hydrogel film showed 429.23 ± 33.23 % swelling in simulated wound fluid. The drug release studies showed slow drug release upto 24 h. Drug release occurred through nonFickian release mechanism and release profile of antibiotic drug moxifloxacin best followed Hixson-Crowell’s model.
International Journal of Pharmaceutics, 2013
Keeping in view the antioxidant nature of the acacia gum and mucoadhesive nature of carbopol hydrogels, in the present studies, an attempt has been made to explore the potential of these materials in designing new hydrogel wound dressings meant for slow release of gentamicin, an antibiotic drug, and to enhance the wound healing potential. The hydrogel films were characterized by SEM, FTIR, XRD and swelling studies. Biomedical properties of hydrogel films like blood compatibility, antioxidant activity, mucoadhesion, antimicrobial activity, oxygen/water vapour permeability, microbial penetration and mechanical properties (tensile strength, burst strength, resilience, relaxation, and folding endurance) have been evaluated. The histological studies of wound healing were also carried out on swiss albino mice of strain Balb C and it has been observed that in case of wounds covered with hydrogel dressings shown faster wound healing, formation of well developed fibroblasts and blood capillaries as compared to open wounds. The results of biomedical properties indicated that hydrogel films are non-thrombogenic, non-haemolytic, antioxidant and mucoadhesive in nature, and are permeable to oxygen and moisture while impermeable to microorganisms. The hydrogel wound dressings have absorbed (8.772 ± 0.184 g/g film) simulated wound fluid. Release of gentamicin drug from wound dressings occurred through Fickian diffusion mechanism in simulated wound fluid.
Development and Characterization of Novel Medicated Hydrogels for Wound Dressing
Soft Materials, 2010
The medicated hydrogels were prepared aseptically under moist heat treatment using polyvinylpyrrolidone (PVP), sodium-carboxymethylcellulose (CMC), polyethyleneglycol (PEG), agar, glycerin and/or boric acid (BA) and designated as PVP-CMC and PVP-CMC-BA. The aim of this study was to develop some medicinal values-based hydrogels. BA was used to build up the medicinal values (antiseptic and antimicrobial properties) within the hydrogels. Optical images, scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy of the hydrogels indicated that boric acid is uniformly dispersed within the cross-linked hydrogel network that may heal and protect the wounds from infections/sepsis. Swelling study in presence of water and physiological saline solution confirmed its reasonable absorption capacity. The rheological properties and mechanical properties demonstrated that the boric acid incorporated hydrogels are quite flexible. Assessment of antimicrobial property study proves that PVP-CMC-BA (3 % BA) has strong infection protection capacity.
Journal of Pharmaceutical and Biopharmaceutical Research, 2019
In the present work an attempt has been made to design the antibiotic drug loaded carbopolpoly(NVP) based hydrogel wound dressings for better wound care. The polymer films were characterized by SEM-EDX, AFM, FTIR, 13 CNMR, TGA/DTA/DTG, DSC, and swelling studies. Besides drug release, various biomedical properties (viz. blood compatibility, mucoadhesion, oxygen permeability, water vapour transmission rate, microbial penetration, tensile strength, bursting strength, resilience, stress relaxation, and folding endurance) have also been studied. The polymer films have been observed to be biocompatible, permeable to oxygen and water vapour and have absorbed simulated wound fluid 11.37±0.31g/g of polymer film. The drug release profile followed the Case-II diffusion mechanism and release profile best fitted in Hixson-Crowell's kinetic models. Mechanical properties results showed that the polymer film had 0.65±0.12 Nmm −2 tensile strength, 119.38±14.26% elongationand 25.49±0.72% resilience.
Permeability and Biocompatibility of Novel Medicated Hydrogel Wound Dressings
Soft Materials, 2010
Hydrogel dressings are being popularized for wound care management because of their softness, tissue compatibility, and ability to enhance wound healing process. PVP-CMC and PVP-CMC-BA hydrogels were prepared using polyvinylpyrrolidone (PVP), sodium-carboxymethylcellulose (CMC), polyethyleneglycol (PEG), agar, glycerine and without/with boric acid (BA). Permeability: water vapor transmission and microbe penetration and biocompatibility: cytotoxicity, skin irritation, and skin sensitization tests of hydrogels were performed. Water vapor transmission ability of hydrogels shows positive response to gas permeability, whereas microbe penetration ability by Staphylococcus aureus and Escherichia coli shoius negative penetrability; thus these two hydrogel dressings could be considered as a good barrier against microbes having an excellent oxygen diffusion property. In vitro assay of cytotoxicity tuas carried out in presence of human immortalized non-tumorigenic keratinocyte cell line (HaCaT), which was further confirmed with balb/c 3T3 mouse fibroblasts cells. The skin irritation test was evaluated on albino rabbits and sensitization test was carried out on albino guineapigs under in vivo stale. Both PVP-CMC and PVP-CMC-BA represented mostly negative effect on cytotoxicity, dermal irritation, and/ or sensitization. All the results indicate that both PVP-CMC and PVP-CMC-BA hydrogels have great potential for biomedical applications, especially for burn skin treatment as well as wound dressings materials.
Open Chemistry
The potentials held by stimuli-responsive polymers in wound dressing have led to the present research in formulating a hydrogel base formulation with polymers having pH and thermo-sensitivity. Thus, hyaluronic acid (pH-sensitive polymer), and Pluronic F-127 (thermo-sensitive polymer) with hydroxypropyl methylcellulose (mucoadhesive polymer) were incorporated to obtain an in situ hydrogel containing gentamicin and naringenin (NAR). The optimization of the stimuli-responsive formulation was performed by the Box–Behnken statistical design to acquire variable parameters that influence the gelling temperature and viscosity. Thermo-gravimetric analysis, differential scanning calorimetry, and Fourier-transform infrared spectroscopy were performed to confirm the suitability of incorporating the selected polymers with drugs. The optimized formulations (blank and drug-loaded) were found to possess satisfactory characteristics of gelling temperatures (30–33°C), viscosities (174 ± 3 to 184 ± 4 ...