Therapeutic Efficacy of Nanoparticles in the Treatment of Diabetes Mellitus. An Overview (original) (raw)

The role of nanotechnology in diabetes treatment: current and future perspectives

International Journal of Nanotechnology, 2011

Diabetes is a chronic disease that currently affects approximately 8% of the US population, and that number is expected to increase significantly by the year 2030. It is imperative that effective monitoring and treatment options be available to patients. Nanotechnology is a focal point in diabetes research, where nanoparticles in particular are showing great promise in improving the treatment and management of the disease. Due to their ability to potentially enhance drug delivery to areas where there are barriers or unfavourable environments for macromolecules, nanoparticles are being explored as vehicles for improved oral insulin formulations. The use of nanotechnology in the development of glucose sensors is also a prominent focus in non-invasive glucose monitoring systems. Finally, compelling but relatively unexplored applications of nanotechnology, such as the development of an artificial pancreas, are discussed. Overall, nanotechnology has the potential to significantly impact several areas of current and future diabetes research.

Nanotechnology in Diagnosis and Treatment of Diabetes Mellitus: Review

2021

Customary techniques for diabetes management require steady and tedious glucose monitoring (GM) and insulin infusions, affecting quality of life. The worldwide diabetic population is required to increment to 439 million, with roughly US$490 billion in medical services consumptions by 2030, forcing a huge trouble on medical care systems around the world. Ongoing advances in nanotechnology have arisen as promising elective methodologies for the management of diabetes. For instance, implantable nano sensors are being created for nonstop GM, new nanoparticle (NP)- based imaging approaches that evaluate subtle changes in β cell mass can encourage early diagnosis, and nano technology-based insulin delivery strategies are being investigated as novel treatments. Here, we give an all-encompassing rundown of this quickly propelling field gathering all viewpoints relating to the management of diabetes.

CURRENT PERSPECTIVES ON USING NANOPARTICLES FOR DIABETES MANAGEMENT

International Journal of Applied Pharmaceutics, 2024

If ignored, Diabetes Mellitus (DM), a chronic metabolic disease marked by high levels of blood glucose, can have serious negative effects on one's health. The efficacy, safety, and patient compliance of traditional treatment approaches, like insulin injections and oral me dications, are frequently hampered. Nanoparticle-based methods have shown promise in recent years as improved diabetes management techniques. Enhanced bioavailability, prolonged therapeutic effects, and targeted drug delivery are just a few of the special benefits that come with using nanoparticles. An overview of current perspectives on using nanoparticles for diabetes control is given in this review. The properties, production processes, and potential uses of several types of nanoparticles, such as polymeric, lipid-based, and inorganic nanoparticles, in the management of diabetes are covered. These nanoparticles allow for the precise delivery of therapeutic agents, such as insulin or anti-diabetic medications, to specific target tissues, like the liver or pancreas. It discusses how inorganic nanoparticles, Polymeric Nanoparticles (PNPs), and Lipid-Based Nanoparticles (LNPs) contribute to improved drug solubility, targeted delivery, and controlled release. Several methods for synthesizing polymeric nanoparticles are described. It also discusses the potential anti-inflammatory and antioxidant properties of some nanoparticles and how crucial they are to lowering diabetes-related issues. By incorporating the most recent research, this review offers a comprehensive summary of the current developments in the use of nanoparticles for diabetes control, paving the way for enhanced therapeutic outcomes and tailored interventions.

Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Diabetes

Nanotechnology is a field encompassing nanostructures, nanomaterials and nanoparticles, which are of increasing importance to researchers and industrial players alike. Nanotechnology addresses the construction and consumption of substances and devices on the nanometer scale. Nanomedicine is a new field that combines nanotechnology with medicine to boost human health care. Nanomedicine is an interdisciplinary field that includes various areas of biology, chemistry, physics and engineering. The most important problems related to diabetes management, such as self-monitoring of blood glucose levels and insulin injections, can now be conquered due to progress in nanomedicine, which offers glucose nanosensors, the layer-by-layer technique, carbon nanotubes, quantum dots, oral insulins, microspheres, artificial pancreases and nanopumps. In this review, the key methodological and scientific characteristics of nanomedicine related to diabetes treatment, glucose monitoring and insulin administration are discussed

Nanoparticles and the new era in diabetes management

Diabetes mellitus (DM) has been known to mankind for more than 2000 years. DM is a group of metabolic disorder characterized by a complete lack of insulin, a relative lack of insulin, or insulin resistance. The increase in prevalence of DM is due to three infl uences: lifestyle, ethnicity, and age. Current challenges in diabetes management include: optimizing the use of the already available therapies to ensure adequate glycemic, blood pressure, and lipid control and to reduce complications. At present several researches have been focusing on new management options for diabetes. Among these options the use of nanomedicine is becoming an eye catching and most promising. The aim of the present review is to provide brief overview of the applications of nanoparticles (NPs) in diabetes management. The development of improved oral insulin administration is very essential for the treatment of DM to overcome the problem of daily subcutaneous injections. In diabetic patients oral administration of insulin can be benefi cial not only to alleviate the pain and trauma caused by injections, but it can also mimic the physiological fate of insulin as well. It has been found that NPs of chitosan, calcium pectinate zinc oxide, alginate, casein and different polymers have been used as a carrier for oral insulin delivery. Buccal administration of insulin with absorption enhancers showed a maximum 12% pharmacological activity. Biodegradable Polymeric NPs for parenteral insulin delivery have also been used, where the insulin matrix surrounded by the nanoporous membrane containing grafted glucose oxidase. A rise in blood glucose level triggers a change in the surrounding nanoporous membrane, resulting in biodegradation and subsequent insulin delivery. Inhalable, polymeric NP-based drug delivery systems have also been tried earlier for the treatment of tuberculosis and cardiovascular disease treatment. Such approaches can be directed toward insulin delivery through inhalable NPs. All previous studies resulted in post treatment accumulation of the NPs in skin and eyes. These drug delivery technologies are in various stages of research and development. The medical applications for nanotechnology are enormous and could give medicine, including the treatment of diabetes, an entirely new outlook.

Applications of nanotechnology in diabetes

Digest Journal of …, 2008

Nanotechnology offers sensing technologies that provide more accurate and timely medical information for diagnosing disease, and miniature devices that can administer treatment automatically if required. Some tests such as diabetes blood sugar levels require patients to administer the test themselves to avoid the risk of their blood glucose falling to dangerous levels. Certain users such as children and the elderly may not be able to perform the test properly, timely or without considerable pain. Nanotechnology can now offers new implantable and/or wearable sensing technologies that provide continuous and extremely accurate medical information.The purpose of this review is to throw more light on the recent advances and impact of nanotechnology on biomedical sciences to cure diabetes.

Nanotechnology for Diabetes: A Review

This review article discusses the potential applications of nanoparticles and BioMEMS as drug delivery systems for diabetes treatment. This manuscript discusses polymeric nanoparticles, oral insulin administration using polysaccharides and polymeric nanoparticles, inhalable insulin nanoparticles formulations, and insulin delivery using BioMEMS. In addition polymeric nanoparticles and treatment of diabetes –associated symptoms are discussed. There are a few limitations in the use of conventionally available drug delivery systems for diabetes treatment. This article reviews the subject in brief with suitable references to original research articles and review articles on earlier and current research findings about various types of nanoparticles and BioMEMS in diabetes treatment and their limitations.

Role of Nanoparticles in the Management of Diabetes

IJPSM, 2021

One of the significant purposes of nanotechnology in the field of medical science is the utilization of nanotechnology in drug delivery to target the tissue for the treatment of disease like diabetes. The biologically compatible nanoparticles with biological, chemical, physical properties may be useful to enhance and overcome the limitations which are caused in the use of traditional medicine system by boosting the rate of drug release ,enhancing drug solubility, and improving the diffusion and distribution of drugs. In this review, we have highlighted on the term diabetes and its different types. Diabetes is becoming an epidemic, more than 366 millions of people around the world are affected. This, article also focuses on the role of nanoparticles in the management of diabetes also its different types of as well as its applications and uses in the treatment of diabetes.