TLR2 Engagement on CD8 T Cells Enables Generation of Functional Memory Cells in Response to a Suboptimal TCR Signal (original) (raw)

TLR2 engagement on CD8 T cells lowers the thresholdfor optimal antigen-induced T cell activation

Jacqueline Marvel

European Journal of Immunology, 2006

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TLR2 engagement on memory CD8 + T cells improves their cytokine-mediated proliferation and IFN-γ secretion in the absence of Ag

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Human Effector CD8+ T Lymphocytes Express TLR3 as a Functional Coreceptor

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TLR ligands differentially modulate T cell responses to acute and chronic antigen presentation

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Peptide Antigen Priming of Naive, But Not Memory, CD8 T Cells Requires a Third Signal That Can Be Provided by IL-12

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A critical role for direct TLR2-MyD88 signaling in CD8 T cell clonal expansion and memory formation following vaccinia viral infection

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Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering

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Stimulation of Human CD4+ T Lymphocytes via TLR3, TLR5 and TLR7/8 Up-Regulates Expression of Costimulatory and Modulates Proliferation

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IL-12 Signals through the TCR To Support CD8 Innate Immune Responses

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Cutting Edge: The Signals for the Generation of T Cell Memory Are Qualitatively Different Depending on TCR Ligand Strength

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Lowering TCR expression on naive CD8+ T cells does not affect memory T-cell differentiation

Juju Gmail

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IFN-γ regulates CD8+ memory T cell differentiation and survival in response to weak, but not strong, TCR signals

Wolfgang Uckert

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The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses

Matthew Martin

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CD8 T Cell Priming in the Presence of IFN- Renders CTLs with Improved Responsiveness to Homeostatic Cytokines and Recall Antigens: Important Traits for Adoptive T Cell Therapy

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Toll-Like Receptor Ligands Directly Promote Activated CD4+ T Cell Survival

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Toll-like receptor 2 controls expansion and function of regulatory T cells

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Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes

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Toll like Receptor 2 engagement on CD4(+) T cells promotes TH9 differentiation and function

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Different T Cell Receptor Signals Determine CD8+ Memory Versus Effector Development

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TLR2 Promotes Th2/Th17 Responses via TLR4 and TLR7/8 by Abrogating the Type I IFN Amplification Loop

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TCR Signal Transduction in Antigen-Specific Memory CD8 T Cells

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The TLR3 agonist poly (I: C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naive recipient mice

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Regulation of T cell activation by TLR ligands

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Regulatory CD4+CD25+ T Cells Restrict Memory CD8+ T Cell Responses

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IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level

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Targeting Antigen to Diverse APCs Inactivates Memory CD8+ T Cells without Eliciting Tissue-Destructive Effector Function

Tony Kenna

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Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering

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Splenic CD8α+ dendritic cells undergo rapid programming by cytosolic bacteria and inflammation to induce protective CD8+ T-cell memory

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Non-redundant role for IL-7R signaling for the survival of CD8+ memory T cells

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