Systemic Lupus Erythematosus with Takayasu’s Arteritis - A Rare Co-existance (original) (raw)

Takayasu’s Arteritis and Systemic Lupus Erythematosus-A Rare Coexistence

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2018

Takayasu arteritis, also known as "pulseless disease" is an inflammatory disease characterized by large caliber artery inflammation. Although tuberculosis and syphilis are known to be associated with Takayasu arteritis, it is rarely found in association with Systemic Lupus Erythematosus (SLE). We report a case of 28-year-old Indian female with SLE, on low dose corticosteroids, she presented with hypertension and developed sudden onset of abdominal pain. She was found to have features suggestive of large vessel vasculitis. The patient was treated with one month of high dose corticosteroids and discharged. She was reviewed, once inflammation subsided and underwent procedure of placement of a self-expandable stent. She had improvement of blood pressure immediate post procedure and reduction of abdominal pain and claudication pain after two weeks of follow up. Although, SLE is known to involve small and medium-sized arteries, large vessel involvement and features of Takayasu arteritis are extremely rare, clinically.

Takayasu’s Arteritis with Systemic Lupus Erythematosus: A Rare Association

Case Reports in Rheumatology, 2015

We report the case of a 24-year-old nondiabetic, nonhypertensive lady with history of fatigue, dyspnoea and limb claudication. She has been diagnosed with Takayasu’s arteritis. Subsequently she developed rash, alopecia, joint pain, and various other laboratory abnormalities which led to a diagnosis of SLE. Takayasu’s arteritis (TA) rarely coexists with systemic lupus erythematosus (SLE). The absence of specific SLE markers in patients with TA who subsequently develop SLE suggests that the coexistence of these conditions may be coincidental. The antiphospholipid syndrome in patients with SLE may mimic the occlusive vasculitis of TA.

Systemic lupus erythematosus associated with vasculitic syndrome (Takayasu’s arteritis)

Rheumatology International, 2010

The occurrence of systemic lupus erythematosus has been only rarely reported in patients with sickle-cell disease. Case presentation: We describe the case of a 23-year-old North-African woman with sickle-cell disease and systemic lupus erythematosus, and discuss the pointers to the diagnosis of this combination of conditions and also present a review of literature. The diagnosis of systemic lupus erythematosus was delayed because our patient's symptoms were initially attributed to sickle-cell disease.

Case Report of Takayasu’s Arteritis

Journal of Evidence Based Medicine and Healthcare, 2016

Takayasu's arteritis (Idiopathic Medial Arthropathy) or "Pulseless" disease is a rare, idiopathic, chronic granulomatous vasculitis that affects aorta and its major branches. This report describes a 30-year-old female who presented with generalised weakness, fatigue, headache, and bilateral arm claudication. Her bilateral upper limb colour duplex study revealed bilateral common carotid arteries and subclavian arteries luminal narrowing and CT angiography revealed vessel wall thickening of aorta and its branches with occlusion. She was diagnosed as having Takayasu's disease (Type V).

Retrospective evaluation of 22 patients with Takayasu’s arteritis

Rheumatology International

Takayasu’s arteritis (TA) is a rare, idiopathic, inflammatory, granulomatous vasculitis that affects the aorta and its primary branches. Clinical features and the pattern of arterial involvement show differences in different regions of the world according to ethnic influences. Our aim in this retrospective study was to evaluate the demographic, clinic, laboratory, and angiographic findings of 22 patients with TA followed by our clinic and also compare our results with series from the literature. The hospital files of the 22 patients followed by our clinic between 1998 and 2009 were retrospectively evaluated. We also compared our results with the series from the literature that we were able to reach by US National Library of Medicine, National Institute of Health. Gender distribution, age at diagnosis, and type of aortic involvement were similar with the study from Turkey. Different clinical manifestations of Takayasu’s arteritis have been described in different ethnic groups. We also want to underline the coincidence of TA and other rheumatic diseases such as sarcoidosis, SLE, RA, and psoriatic arthritis, different from other published series.

A Case Report of Takayasu’s Arteritis

Medicine Today, 2013

Takayasu’s arteritis, or “pulseless” disease is a rare, idiopathic, chronic granulomatous vasculitis that affects aorta and its major branches. This report describes a 57- year-old man who presented with gradual loss of vision, syncopal attack and arm claudication. His ocular findings suggested bilateral ocular ischemic syndrome. He was later diagnosed as having Takayasu’s disease.DOI: http://dx.doi.org/10.3329/medtoday.v24i2.15013 Medicine Today 2012 Vol.24(2): 79-81

Atherosclerosis in Takayasu arteritis

Annals of the Rheumatic Diseases, 2006

Objective: Chronic inflammatory diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis are associated with accelerated atherosclerosis. We hypothesised that atherosclerosis may also be increased in Takayasu arteritis. Methods: The frequency of atherosclerotic plaques and the intima-media thickness (IMT) were investigated in 30 female patients with Takayasu arteritis (mean age (standard deviation), 35.4 (8.0) years), along with 45 sex-matched and age-matched patients with SLE (37.4 (6.8)) and 50 healthy controls (38.2 (5.7)). Plaques were scanned and IMT was measured at both sides of the common carotids, carotid bulb, and internal and external carotid arteries by B-mode ultrasonography. Traditional risk factors for atherosclerosis were also assessed. Results: Most of the atherosclerotic risk factors were comparable between patients with Takayasu arteritis and SLE. More atherosclerotic plaques were observed among patients with Takayasu arteritis (8/30; 27%) and those with SLE (8/45; 18%) than among the healthy controls (1/50; 2%; p = 0.005). Logistic regression analyses showed that the presence of a plaque was associated only with age in both Takayasu arteritis and SLE (p = 0.04 and 0.02, respectively). The mean overall IMT was significantly higher among patients with Takayasu arteritis (0.95¡0.31 mm) than among the patients with SLE (0.58¡0.10 mm) and the healthy controls (0.59¡0.08 mm; p,0.001). Conclusion: Patients with Takayasu arteritis have a high rate of atherosclerotic plaques, at least as frequent as that observed among patients with SLE.

A Case Report: A 37 Years-old Women with Takayasu Arteritis

Journal of Pharmaceutical Research International, 2021

Background: A rarity of form of vasculitis, also known as TAK, induces inflammation in the walls of the major arteries in the body: the aorta and its main branches. The disease results from a body attack and inflammation of the walls of the arteries caused by the body's own immune system. Case Presentation: A 37-years-old women had complaints of fever, giddiness, weakness of right upper limb and lower limb since1 day. After undergoing whole blood count, liver function examination, renal and MRI function checks, CT scan, angiography, etc. was studied. She was diagnosed with takayasu arteritis. She had past medical history of neck pain and numbness since January 2020. For these complaints her family members referred her in private hospital. There is no significant history of surgery in present, lower segment caesarean section and piles operation was done previously. Physical findings were normal except the Glasgow Coma Scale score was 11 that is, patient was semi-conscious, In G...

Takayasu Arteritis: An Exceptionally Advanced Clinical Presentation

CERN European Organization for Nuclear Research - Zenodo, 2022

Takayasu Arteritis (TKA) is granulomatous inflammation of the proximal aorta and its main branches, characterized by granulomatous inflammation. As compared to Giant Cell Arteritis (GCA), diagnosis of TKA is a clinical challenge owing to vague initial symptoms and impossibility to biopsy major vessels, therefore, clinical and radiological parameters are the main diagnostic standards. Ishikawa's guidelines were the first clinical guideline regarding the diagnosis of TKA, however, guidelines by the American College of Rheumatology are the mainstay of clinical diagnosis. The development of TKA has been associated with Mycobacterium tuberculosis infection and with rheumatic fever in case series, but the exact trigger factor is unknown to the best of our knowledge. Damage caused by TKA is irreversible due to ischemic changes, therefore active disease status, and end-organ damage presenting as renal artery stenosis, severe hypertension, and shrunken kidneys are the poor prognostic factors. TKA is the most common cause of non-atherosclerotic vascular stenosis. We present a case of a young female, who presented at 16 years of age with involvement of ascending and descending aorta that required coronary artery bypass grafting at age of 17 and later on required Percutaneous Coronary Stenting to Left Main Stem too. Due to worsening hypertension and shrinking kidneys, she required renal artery stenting. In the course of progression, she developed radial artery and carotid artery stenosis, however, the disease progress started to halt, once she was started on glucocorticoids.

Takayasu's arteritis: A study of 104 Italian patients

Arthritis and Rheumatism, 2005

ObjectiveTakayasu's arteritis (TA) is a rare vasculitis. The Italian Takayasu's Arteritis study group was established with the aim to describe a large cohort of patients.Takayasu's arteritis (TA) is a rare vasculitis. The Italian Takayasu's Arteritis study group was established with the aim to describe a large cohort of patients.MethodsData were collected by means of an ad hoc form. Demographic information, clinical history, vascular findings, treatment, risk factors, and comorbidities were analyzed.Data were collected by means of an ad hoc form. Demographic information, clinical history, vascular findings, treatment, risk factors, and comorbidities were analyzed.ResultsData of 104 patients were collected. The median delay in diagnosis was 15.5 months (range 0–325 months). Age at onset <15 years was associated with a higher probability, whereas elevated erythrocyte sedimentation rate with a lower probability, of a delay in diagnosis. The majority of patients experienced nonspecific signs and symptoms indicative of an inflammatory disease in the early phase. Among vascular involvement, stenosis was the most frequent lesion, being present in 93% of patients, followed by occlusion (57%), dilatation (16%), and aneurysm (7%). Glucocorticoids were the mainstay of treatment in our series; however, treatment with cytotoxic agents was required in about half of the patients. Fifty-two patients underwent at least 1 surgical procedure. The main indications for intervention were renal vascular hypertension, cerebral hypoperfusion, and limb claudication.Data of 104 patients were collected. The median delay in diagnosis was 15.5 months (range 0–325 months). Age at onset <15 years was associated with a higher probability, whereas elevated erythrocyte sedimentation rate with a lower probability, of a delay in diagnosis. The majority of patients experienced nonspecific signs and symptoms indicative of an inflammatory disease in the early phase. Among vascular involvement, stenosis was the most frequent lesion, being present in 93% of patients, followed by occlusion (57%), dilatation (16%), and aneurysm (7%). Glucocorticoids were the mainstay of treatment in our series; however, treatment with cytotoxic agents was required in about half of the patients. Fifty-two patients underwent at least 1 surgical procedure. The main indications for intervention were renal vascular hypertension, cerebral hypoperfusion, and limb claudication.ConclusionAs with many rare diseases, delay in diagnosis is an important issue for patients with TA. The increasing occurrence of vascular lesions along with the disease progression put to question the long-term effectiveness of contemporary treatment. These data may be helpful in increasing physicians' awareness to prevent diagnosis delay, update guidelines, and plan future research projects.As with many rare diseases, delay in diagnosis is an important issue for patients with TA. The increasing occurrence of vascular lesions along with the disease progression put to question the long-term effectiveness of contemporary treatment. These data may be helpful in increasing physicians' awareness to prevent diagnosis delay, update guidelines, and plan future research projects.