The effect of cyclodextrin on both the agglomeration and the in vitro characteristics of drug loaded and targeted silica nanoparticles (original) (raw)
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Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2018
The objective of this research was to investigate the effect of polymer length on the in vitro characteristics of thymoquinone-melatonin (TQ-MLT) when loaded into our previously prepared targeted drug delivery system (TDDS). Our system constructed from silica nanoparticles (NPs) and modified with diamine polymer (D4000), carboxymethyl-β-cyclodextrin (CM-β-CD) and folic acid (FA), respectively. In this study, three other different lengths of polymers (D230, D400 and D2000) were used and compared to D4000. The surface modification was characterized using fourier transform infrared spectroscopy (FTIR) and the mean particle size as well as polydispersity (PD) was measured using dynamic light scattering (DLS). The results, in general, showed that the release rate increases as the polymer length decreases. Also, shorter polymers showed an obvious burst release of most of the drug within the first hour. On the other hand, longer polymers exhibited a more sustained release in a pulsatile ma...
Biomaterials, 2009
The aim of this study was to develop nanoparticles made of the amphiphilic cyclodextrin heptakis (2-Ooligo(ethyleneoxide)-6-hexadecylthio-)-b-CD (SC16OH) entrapping docetaxel (Doc) and establish their in vivo potential. Doc-loaded SC16OH nanoparticles were prepared by the emulsion-solvent evaporation technique and fully characterized for size, zeta potential, amount of entrapped drug, release rate and degradation rate. Spherical vesicular nanoparticles displaying a hydrodynamic radius of about 95 nm which did not change upon storage as an aqueous dispersion, a negative zeta potential and entrapment efficiency of Doc very close to 100% were produced. DSC study highlighted the crystalline nature of SC16OH, unloaded and Doc-loaded SC16OH nanoparticles which resulted in their very slow dissolution during release stage and well-modulated release of entrapped Doc for about 8 weeks. Doc-loaded SC16OH nanoparticles were not hemolytic toward red blood cells as compared to a commercial Doc formulation (Taxotere Ò ) which shows a dose-dependent toxicity. After exposure of HEp-2 cells to equivalent doses of free Doc and Doc-loaded SC16OH nanoparticles, superior cell killing and cell damage were observed for nanoparticles. Finally, cell damage was attributed to aberrant mitosis which was found to be significantly higher for HEp-2 cells treated with Doc-loaded SC16OH nanoparticles as compared to free Doc likely due to the ability of nanoparticles to slowly release the drug allowing prolonged cell arrest in mitosis. Taken together, these results highlights a great potential of nanoparticles based on SC16OH in solid tumors therapy.
Pharmaceutics
In drug delivery, one widely used way of overcoming the biopharmaceutical problems present in several active pharmaceutical ingredients, such as poor aqueous solubility, early instability, and low bioavailability, is the formation of inclusion compounds with cyclodextrins (CD). In recent years, the use of CD derivatives in combination with nanomaterials has shown to be a promising strategy for formulating new, optimized systems. The goals of this review are to give in-depth knowledge and critical appraisal of the main CD-modified or CD-based nanomaterials for drug delivery, such as lipid-based nanocarriers, natural and synthetic polymeric nanocarriers, nanosponges, graphene derivatives, mesoporous silica nanoparticles, plasmonic and magnetic nanoparticles, quantum dots and other miscellaneous systems such as nanovalves, metal-organic frameworks, Janus nanoparticles, and nanofibers. Special attention is given to nanosystems that achieve controlled drug release and increase their bioa...
Development of Nonsurfactant Cyclodextrin Nanoparticles Loaded With Anticancer Drug Paclitaxel
Journal of Pharmaceutical Sciences, 2008
In the current formulation of clinical use paclitaxel (PCX) is associated with solubilizers that may produce severe side effects. In this study, PCX was complexed to an amphiphilic cyclodextrin (CD), 6-O-CAPRO-b-CD, capable of forming nanoparticles spontaneously in order to mask its physicochemical properties via the formation of inclusion complexes of the drug with amphiphilic CD before the nanoparticle is formed. Complexes have been characterized with various techniques such as 1 H NMR, Fourier Transform Infrared (FTIR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) confirming the formation of inclusion complex between PCX and 6-O-CAPRO-b-CD. Nanospheres and nanocapsules were prepared directly from the preformed PCX/6-O-CAPRO-b-CD inclusion complex by the nanoprecipitation technique, showing a size from 150 to 250 nm for nanospheres and from 500 to 500 nm for nanocapsules. Zeta potentials of the nanospheres and nanocapsules indicate stable colloidal dispersions within the range of À18 to À39 mV. A 12-month physical stability was demonstrated for blank nanoparticles. PCX encapsulation was high with threefold increase in loading when nanoparticles are prepared directly from preformed inclusion complexes of the drug with 6-O-CAPRO-b-CD. In vitro liberation profiles of PCX from CD nanoparticles show a prolonged release profile for this drug up to 12 h for nanospheres and 24 h for nanocapsules.
Vietnam Journal of Science and Technology, 2020
Porous nano-silica (PNS) as promising targeted drug nanocarriers has become a new area of interest in recent years due to their tunable pore sizes and large pore volumes, high chemical and thermal stability, and excellent biocompatibility. These unique structures of PNS facilitate effective protecting drugs from degradation and denaturation. However, it has certain limitations for being used in pharmaceutical such as a burst release of encapsulated drugs. In this study, the effects of grafting cyclodextrin (CD) as gatekeeper through the biodegradable disulfide bonds on doxorubicin (DOX) release was investigated. The morphology and pore channel structures of these modified PNS were assessed by transmission electron microscopy (TEM). Fourier transform infrared spectroscopy (FT-IR) was utilized to evaluate the functional groups on PNS surface. In vitro tests were conducted for the drug loading and releasing efficiency. The results demonstrated that the prepared DOX@PNS-SS-A/CD was sphe...
Expert Opinion on Drug Delivery, 2016
Introduction: In light of the recent development of new soft materials, nanostructured selfassembled systems have attracted attention in a variety of technological fields of high social impact. Cyclodextrin nanosponges (CDNS) represent a new and highly versatile class of cross-linked cyclodextrin (CD)-based nanoporous polymers. Their intriguing properties, including safety, biodegradability, negligible toxicity, marked swelling behavior, superior inclusion capability with respect to native CD, are the bases for potential for applications in drug delivery, tissue engineering and regenerative medicine. Areas covered: We report on the state-of-art concerning a detailed characterization of structural and dynamical features of CDNS explored by the combined use of different and complementary techniques, such as Fourier transform infrared absorption in attenuated total reflectance geometry (FTIR-ATR) and Raman spectroscopies, and high resolution magic angle spinning (HR-MAS) NMR spectroscopy. The ambitious objective is to furnish an exhaustive survey of the role played by hydrophobic and hydrophilic groups within the cross-linked network, in dry and swollen states, in determining the macroscopic functional features of CDNS. Expert opinion: The reported results may significantly contribute in the rational design and optimization of new stimuli-responsive systems exhibiting tunable inclusion/release properties, adapted to the therapeutic demands of pathology.
Journal of Microencapsulation, 2006
Nanospheres and nanocapsules of an amphiphilic-cyclodextrin,-CDC6, were evaluated using a group of steroid drugs to determine the effect of drug physicochemical properties (e.g. partition coefficient, drug:CD association constant k 1:1 , aqueous solubility) on loading and release profiles of the nanoparticles. Model drugs used were hydrocortisone, testosterone and progesterone. Inclusion complexes were formed between model drugs and-CDC6 by the co-lyophilization technique and were characterized by DSC analysis and FTIR spectroscopy. Nanospheres and nanocapsules were prepared directly from these inclusion complexes and alternatively by the conventional preparation technique. It was observed that loading depended highly on the technique used. For nanospheres, drug characteristics played a significant role while for nanocapsules this factor had no significant effect on loading values. Release of drugs from nanospheres was completed in 2 h, regardless of drug physicochemical properties with high-loading technique. On the other hand, drug release from nanocapsules was largely dependent on drug properties. Only 30% of progesterone was released in 24 h, while hydrocortisone was completely released in 8 h. Thus, drug properties are significant for the formulation of nanocapsules and nanospheres. Desired loading and release properties could be achieved by selecting the appropriate drug delivery system and the optimum drug.
Journal of colloid and interface science, 2018
Nanoparticles are normally classified as "hard", mainly consisting of metal or metal oxide cores, or "soft", including polymer-based, liposomes and biomimetic nanoparticles. Soft nanoparticles have been studied in depth for drug formulation and therapeutic delivery applications, albeit hard nanoparticles may offer easier synthesis, smaller size and more effective tumor penetration. Among them, silica nanoparticles maintain excellent biocompatibility and biodegradability and can be finely adjusted in size and shape, easily produced in a large scale and functionalized or loaded with active molecules. To help filling the gap of a poor clinical translation of hard nanoparticles, we have designed and developed three different nonporous silica nanocarriers loading the chemotherapeutic doxorubicin within the core matrix, on the surface or both inside and outside, respectively. A comparative study was performed on drug loading and drug release, silica matrix degradation ...
International Journal of Pharmaceutics, 1996
A new nanosphere carrier system has been obtained from amphiphilic fl-cyclodextrin (fatty acid chains varying from 2 to 14 carbons grafted at the 02 and 03 positions of fl-cyclodextrin). The nanospheres, with a mean diameter varying between 90 and 150 nm, are prepared by progressive dispersion of an organic solution of modified fl-cyclodextrin in an aqueous phase with or without surfactant. Various physicochemical parameters have been studied: the effect of the chain length of acyl groups (flCD with 6, 12 and 14 fatty acid carbons), and type of surfactant on the size and physicochemical properties and stability of the nanospheres. A preliminary investigation of water-soluble and insoluble drug entrapment by nanospheres was carried out.