Treatment of Renal Carcinoma in a Binturong (Arctictis Binturong) with Nephrectomy and a Tyrosine Kinase Inhibitor (original) (raw)
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Brazilian Journal of Veterinary Pathology
Primary renal neoplasms are infrequent in domestic animals and birds, being budgerigars an exception. This report describes a papillary renal adenoma in a toco toucan (Ramphastos toco), which was euthanized due to poor prognosis after surgical intervention of phalanx fractures in both wings. Grossly, the caudal pole of the right kidney had a nodular lesion measuring 3.5 x 1.7 x 1.5 cm. Microscopically, there was a well delimited neoplasm arranged in large and coalescent papillary structures composed by a single layer of epithelial cells. There was mild to moderate nuclear and cytoplasmic pleomorphism, whereas mitotic figures were absent. In conclusion, this tumor was considered as an accidental finding, which is similar to the majority of adenomas reported in domestic mammals.
Neoplastic disease Urothelial carcinoma in a Russian tortoise (Testudo horsfieldii
Journal of Comparative Pathology, 2023
An adult female Russian tortoise (Testudo horsfieldii) was admitted to a veterinary clinic with a 1-week history of anorexia and lethargy. Physical examination revealed significant dehydration and generalized dysecdysis. Blood parameters were all within species-reported limits. Radiography revealed an increased amount of soft tissue opacity within the coelomic cavity and a distinct loss of serosal detail. A large cavitated mass was detected ultrasonographically in the right coelom and a tentative diagnosis of kidney pathology was made. Using computed tomography and magnetic resonance imaging, a partly mineralized heterogeneous mass was seen in the right coelom. After stabilization, a transplastron coeliotomy was performed. A 7 Â 5 cm mass, including associated cysts, was removed. The tortoise died 8 h postoperatively and post-mortem examination revealed a urothelial carcinoma arising from the renal pelvis. To the authors' knowledge, this is the first report in a tortoise of urothelial carcinoma, which has rarely been reported in reptiles.
A case report of renal cell carcinoma in a dog
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2013
Mix renal carcinoma was noticed during the necropsic examination of a 14 year old mix breed female. Tumours were bilateral and metastasis was noticed in the spleen and myocard. Histological examination evidenced morphological aspects characteristic to the mixt renal carcinoma. Histological aspects described in this individual characterize renal cell carcinoma, also known as renal adenocarcinoma, hypernephroma or, in older literature, Grawitz tumour.
Renal cell carcinoma in a dog: pathologic and cytologic findings.
This study presents a dog with a history of anorexia, vomiting and abdominal distention of one week duration. Abdominal palpation revealed a mass in the right abdominal quadrant. Laboratory abnormalities included slight anaemia, leukocytosis, thrombocytosis, hypoalbuminaemia, hypokalaemia, hypocalcaemia and metabolic acidosis. Urine was reddish in color with 3+ protein and blood reaction, 2+ leukocyte, and 2+ glucose. Erythrocytes and leukocytes casts and innumerous renal and transitional epithelial were present. Ultrasonographic examination revealed a solitary mass taking the place of right kidney. Urine sediment cytology revealed large clusters of markedly pleomorphic cells. Mitotic figures in some cells were observed. A large tumour mass was found at laparotomy. The right kidney was replaced by this massive ball shaped tumour. Unilateral nephrectomy was performed and renal cell carcinoma was diagnosed by microscopic examination.
Malignant Nephroblastoma in a Common Marmoset (Callithrix jacchus)
Veterinary Pathology, 2008
Necropsy of a 17-month-old male common marmoset (Callithrix jacchus) with a history of increased abdominal girth resulted in the finding of a unilateral polycystic renal neoplasm. Detailed histopathologic and immunohistochemical investigations revealed different tissue types within the tumor including stromal connective tissue and fusiform mesenchymal cell formations surrounding blastemal cells as well as different developmental stages of organ-specific epithelial cells accompanied by extensive cyst formation. Metastases were not observed. In consideration of the macroscopic, histologic, and immunohistochemical findings, the tumor was classified as a nephroblastoma closely resembling the socalled Wilms' tumor, a malignant embryonic renal tumor frequently observed in humans, especially in young children. In contrast, this tumor entity has rarely been observed in nonhuman primates. This report represents the first documented case of a cystic variant of nephroblastoma in a nonhuman primate.
Journal of Fish Diseases, 2020
Syngnathidae (seahorses, pipefish and seadragons) are charismatic species commonly kept in commercial aquaria, but published literature on syngnathid diseases is limited and immunohistochemical techniques not routinely employed. A retrospective review of 2541 syngnathid submissions received between March 2003 and October 2016 identified 18 neoplasms including germ cell tumours, exocrine pancreatic and intestinal carcinomas, chromatophoromas, and single cases of lymphoma, thyroid and renal carcinoma, swim bladder and pituitary adenoma. Big bellied seahorses accounted for 19% of submissions but 50% of neoplasms were diagnosed in this species. This study includes the first reported cases of germ cell tumours, chromatophoroma, thyroid carcinoma and pituitary adenoma in Syngnathidae and the first reports of neoplasia in pipefish species. Out of nine commercial antibodies trialled for immunohistochemical characterisation of neoplastic tissue only pancytokeratin proved cross-reactive. Electron microscopy was performed on four cases. Tumours should be considered as differential diagnosis in cases with buoyancy issues, debilitated or emaciated animals, and may predispose to secondary infections. This study highlights the value of histopathological disease surveillance for commercial aquarium settings.
Principles and Applications of Medical Oncology in Exotic Animals
Veterinary Clinics of North America: Exotic Animal Practice, 2017
Neoplasia and successful therapy for neoplasia has been reported in fish, birds, reptiles, small mammals, primates, and megavertebrates. 1-6 This article introduces medications and therapeutic approaches being used in a variety of exotic animal species (Table 1). These animals range in size from grams to thousands of pounds. Discussion of administration techniques will also be introduced. Medical treatment of cancer is still largely used as an adjunctive or palliative treatment. However, there are therapies that can produce remission for months to years, depending on the animal, tumor type, and stage of disease. The acceptance of many exotic species into the human family unit has contributed to owners who are seeking out and are willing to dedicate the financial and emotional resources for improved medical care and therapeutics for their pets.
Primary Renal Neoplasia of Dogs
Journal of Veterinary Internal Medicine, 2006
Background: Primary renal tumors are diagnosed uncommonly in dogs. Hypothesis: Signs and survival will differ among different categories of primary renal tumors. Animals: Data were collected from the medical records of 82 dogs with primary renal tumors diagnosed by examination of tissue obtained by ultrasound-guided biopsy, needle aspiration, surgery, or at postmortem examination.